1. The impurity of diuretic hydrochlorothiazide 04, also be a medical intermediate.
2. It’s mainly used for the detection of drug impurities, the synthesis of hydrochlorothiazide and the screening of medical structural fragments.
3. Presents a weak alkaline,refrigeration.
. Recommended Products is: 5250-72-6 and 22503-72-6.
The present work describes a simple, sensitive, and highly specific reverse phase high performance liquid chromatog. method for the simultaneous determination of impurities of lisinopril and hydrochlorothiazide from their combined dosage form. Symmetry C18 column and a mobile phase comprising of 1-hexanesulfonic acid sodium salt, triethylamine, H3PO4, acetonitrile, and methanol was used for this method. The validation showed that the method has acceptable specificity, recovery, linearity, solution stability, and precision. This method remains unaffected by small but deliberate variations, which are described in ICH guidelines.
Simultaneous determination of lisinopril and hydrochlorothiazide related impurities in lisinopril and hydrochlorothiazide combined tablet dosage forms using HPLC. Recommended basis is hydrochlorothiazide 20. Products is: https://www.ambeed.com/products/742-20-1.html, 432499-63-3
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem