Application of 151230-42-1

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6-Bromo-2-methylbenzo[d]oxazole, 151230-42-1

151230-42-1, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 6-Bromo-2-methylbenzo[d]oxazole, cas is 151230-42-1,the benzoxazole compound, it is a common compound, a new synthetic route is introduced below.

A mixture of 1.0 mmol of 6-bromo-2-methyl-benzooxazole [151230-42-1], 2 mmol of acrylonitrile, 1.0 mmol of sodium acetate, 0.1 mmol of Pd(OAc)2 and 0.2 mmol of P(o-tolyl)3 in 3 ml of DMF under N2 atmosphere is treated at 1500C for 1 h in the microwave. The reaction is filtered through a short plug of Hyflow. The solvent of the filtarate is concentrated by evaporation. The title compound is obtained from the residue by chromatography on Varian Mega Bond Elut (Si) eluting with EtOAc to a mixture of petroleum ether/EtOAc 10:1 to afford the title compound as a mixture of cis and trans geometric isomers. Rf = 0.15 (CH2CI2-MeOH 100:2); Rt = 4.48.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 6-Bromo-2-methylbenzo[d]oxazole, 151230-42-1

Reference：
Patent; NOVARTIS AG; WO2009/135526; (2009); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem