701-16-6, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5-Fluoro-2-methylbenzo[d]oxazole, cas is 701-16-6,the benzoxazole compound, it is a common compound, a new synthetic route is introduced below.
[0614] To a stirred solution of Comp-50c (0.073 g, 0.48 mmol) in mixture of THF (5 mL) and tBuOH (0.5 mL) was added t-BuOK (0.16 g, 1.46 mmol) at 0 C. Comp-80b (0.1 g, 0.48 mmol) was added portion wise and the reaction mixture was stirred at RT for 16 h. Progress of the reaction was monitored by TLC and LCMS. After completion, the reaction mixture was quenched with H20 (5 mL) and extracted with EtOAc (10 mL X 2). The organic layer was washed with brine, separated, dried over anhydrous Na2SC>4 and concentrated under reduced pressure. The crude obtained was purified by column chromatography (silica, 100- 200 mesh, 2-5% EtOAc in hexane) to afford (E)-2-(2-(l-cyclohexyl-2,5-dimethyl-lH-pyrrol- 3-yl)vinyl)-5-fluorobenzo[d]oxazole (104, 0.08 g, 51%) as a yellow solid. (1076) [0615] HPLC Purity: 99.4% (1077) [0616] MS (ESI) m/e [M+H]+/ Rt’%: 339.15/2.56/99.8% (1078) [0617] 1H NMR (400 MHz, DMSO-d6) delta 1.17 – 1.27 (m, 2 H), 1.35 – 1.45 (m, 2 H), 1.62 – 1.69 (m, 1 H), 1.73 – 1.96 (m, 6 H), 2.22 – 2.27 (m, 3 H), 2.35 – 2.39 (m, 3 H), 6.20 – 6.25 (m, 1 H), 6.46 – 6.53 (m, 1 H), 7.09 – 7.16 (m, 1 H), 7.41 – 7.48 (m, 1 H), 7.60 – 7.66 (m, 1 H), 7.66 – 7.70 (m, 1 H).
Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5-Fluoro-2-methylbenzo[d]oxazole, 701-16-6
Reference：
Patent; ALPINE ANDROSCIENCES, INC.; PATIL, Santhosh N.; SARMA, Bugga VNBS; (148 pag.)WO2019/152731; (2019); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem