122433-29-8, An article , which mentions 122433-29-8, molecular formula is C9H7NO2. The compound – 1-(Benzo[d]oxazol-2-yl)ethanone played an important role in people’s production and life.
Acyclic phosph(on)ate inhibitors of Plasmodium falciparum hypoxanthine-guanine-xanthine phosphoribosyltransferase
The pathogenic protozoa responsible for malaria lack enzymes for the de novo synthesis of purines and rely on purine salvage from the host. In Plasmodium falciparum (Pf), hypoxanthine-guanine-xanthine phosphoribosyltransferase (HGXPRT) converts hypoxanthine to inosine monophosphate and is essential for purine salvage making the enzyme an anti-malarial drug target. We have synthesized a number of simple acyclic aza-C-nucleosides and shown that some are potent inhibitors of Pf HGXPRT while showing excellent selectivity for the Pf versus the human enzyme.
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Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem