New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products has revolutionised modern synthetic chemistry. In an article, author is Tariq, Sana, once mentioned the application of 104-88-1, Electric Literature of 104-88-1, Name is 4-Chlorobenzaldehyde, molecular formula is C7H5ClO, molecular weight is 140.567, category is benzoxazole. Now introduce a scientific discovery about this category.
Novel N-(benzothiazol/oxazol-2-yl) 2 [(5-(phenoxymethyl)-4-aryl-4H-1,2,4-triazol-3-yethio] acetamide derivatives (5a-n) were synthesized and investigated for in vitro anti-inflammatory activity and p38 alpha MAP kinase inhibition. Compounds showing good in vitro activities (5a, 5b, 5d, 5e, 5i, 5k and 5l) were studied for their in vivo anti-inflammatory activity using carrageenan induced rat paw edema model. Compound 5b emerged as the most active compound with an edema inhibition of 84.43%. It also showed improved GI safety profile with lower ulcer severity index and lipid peroxidation potential. Also, p38 alpha MAP kinase assay of 5b showed superior inhibitory potency (IC50:0.031 +/- 0.14 mu M) than the standard SB 203580 (IC50:0.043 +/- 0.14 mu M). To predict their binding mode compounds were also docked against p38 alpha MAP kinase enzyme. Compound 5b and SB 203580 showed hinge region interaction with MET 109.
Electric Literature of 104-88-1, One of the oldest and most widely used commercial enzyme inhibitors is aspirin, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 104-88-1.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem