In heterogeneous catalysis, the catalyst is in a different phase from the reactants. Recommanded Product: 2-(Trifluoromethyl)benzo[d]oxazole, At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 2008-04-0, name is 2-(Trifluoromethyl)benzo[d]oxazole. In an article£¬Which mentioned a new discovery about 2008-04-0
ASYMMERTIC SYNTHESIS OF Beta-SUBSTITUTED alpha-AMINO ACIDS VIA A CHIRAL Ni(II) COMPLEX OF DEHYDROALANINE
An efficient approach to the asymmetric synthesis of beta-substituted (S)-alanines is describen.The chiral Ni(II) complex of a Schiff base derived from (S)-o-N-(N-benzylpropyl)aminobenzophenone (BBP) and glycine was treated with formaldehyde and sodium methoxide to give a corresponding (R)-serine complex which, in turn, was converted to the chiral Ni(II) dehydroalanine complex.Michael type base catalyzed addition of nucleophiles (including MeOH, Me2NH, PhCH2NH2, imidazole, PhSH, PhCH2SH,, malonic ester and benzylmagnesium chloride) produced a mixture of diastereoisomeric complexes with a 70-90percent excess of S,S (or L,L) isomers over the S,R (or L,D) ones.The cleavage of pure diastereoisomers with aqueous HCl gave, in good yields, beta-substituted (S) (or L)-alanines and regenerated the chiral auxiliary (BBP).
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Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem