One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, HPLC of Formula: C7H4FNO2, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 13451-79-1, Name is 5-Fluorobenzo[d]oxazol-2(3H)-one, molecular formula is C7H4FNO2
Optimization of N-benzyl-benzoxazol-2-ones as receptor antagonists of macrophage migration inhibitory factor (MIF)
The cytokine MIF is involved in inflammation and cell proliferation via pathways initiated by its binding to the transmembrane receptor CD74. MIF also exhibits keto-enol tautomerase activity, believed to be vestigial in mammals. Starting from a 1 muM hit from virtual screening, substituted benzoxazol-2-ones have been discovered as antagonists with IC50 values as low as 7.5 nM in a tautomerase assay and 80 nM in a MIF-CD74 binding assay. Additional studies for one of the potent inhibitors demonstrated that it is not a covalent inhibitor of MIF and that it attenuates MIF-dependent ERK1/2 phosphorylation in human synovial fibroblasts.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. HPLC of Formula: C7H4FNO2, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 13451-79-1, in my other articles.
Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem