In an article, author is Pino-Cuevas, Arantxa, once mentioned the application of 583-55-1, HPLC of Formula: C6H4BrI, Name is 1-Bromo-2-iodobenzene, molecular formula is C6H4BrI, molecular weight is 282.9, MDL number is MFCD00001030, category is benzoxazole. Now introduce a scientific discovery about this category.
Thiosemicarbazonate complexes with affinity for amyloid-beta fibers: synthesis, characterization and biological studies
Aim: Obtain radioimages of amyloid-beta fibers using Tc-99m-complexes. Methodology: Tridentate thiosemicarbazone and thiocarbonohydrazone ligands containing fragments (stilbene, azobenzene, benzothiazole or benzoxazole) with affinity for amyloid-beta fibers and its Re(I) complexes have been prepared. The molecular structures of several ligands and complexes were determined by x-ray diffraction. Binding affinity studies toward A beta 1- 42 fibers were performed for the ligands and Re(I) complexes. The ability of formation of some Tc-99m(I) complexes, their biodistribution and in vivo stability have been established. Results & conclusion: Complexes of stilbene and benzothiazole thiosemicarbazonates show similar affinity for amyloid-beta fibers to the free ligand. These Tc-99m complexes present a reasonable in vivo stability and a low capability to cross the blood-brain barrier although not sufficient to brain amyloid imaging.
If you are interested in 583-55-1, you can contact me at any time and look forward to more communication. HPLC of Formula: C6H4BrI.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem