Chemistry, like all the natural sciences, Safety of 3,3-difluorocyclobutanamine hydrochloride, begins with the direct observation of nature¡ª in this case, of matter.637031-93-7, Name is 3,3-difluorocyclobutanamine hydrochloride, SMILES is NC1CC(F)(F)C1.[H]Cl, belongs to benzoxazole compound. In a document, author is Srivastava, Pavan, introduce the new discover.
Design and development of some phenyl benzoxazole derivatives as a potent acetylcholinesterase inhibitor with antioxidant property to enhance learning and memory
Based on the Gaussian-based quantitative structure-activity relationship (QSAR) and virtual screening (VS) processes, some promising acetylcholinesterase inhibitors (AChEls) having antioxidant potential were designed synthesized, characterized, and evaluated for their ability to enhance learning and memory. The synthesized phenyl benzoxazole derivatives exhibited significant antioxidant potential and AChE inhibitory activity, whereas the antioxidant potential of compound 34 (49.6%) was observed significantly better than standard donepezil (<10%) and parallel to ascorbic acid (56.6%). Enzyme kinetics study of most potent compound 34 (AChE IC50 = 0.363 +/- 0.017 mu M; Ki = 0.19 +/- 0.03 mu M) revealed the true nature and competitive type of inhibition on AChE. The compound 34 was further assessed for in vivo and ex vivo studies and the results showed the significant reversal of cognitive deficits and antioxidant potential at the dose of 5 mg/kg comparable to standard drug donepezil. (C) 2018 Elsevier Masson SAS. All rights reserved. Note that a catalyst decreases the activation energy for both the forward and the reverse reactions and hence accelerates both the forward and the reverse reactions. you can also check out more blogs about 637031-93-7. Safety of 3,3-difluorocyclobutanamine hydrochloride.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem