Hayashi, Shigeo; Ohashi, Katsuyo; Mihara, Sachiko; Nakata, Eriko; Emoto, Chie; Ohta, Atsuko published an article about the compound: 2,3-Dihydrospiro[indene-1,4′-piperidine] hydrochloride( cas:96651-85-3,SMILESS:Cl.C1CC2(CCNCC2)C2=CC=CC=C12 ).Synthetic Route of C13H18ClN. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:96651-85-3) through the article.
A series of (4-arylpiperidine substituted-methyl)-[bicyclic (hetero)cycloalkanobenzene] analogs, e.g., I was designed, synthesized, and biol. evaluated in vitro to seek and identify potent and selective small-mols. of nonpeptide NOP receptor antagonists, which resulted in the discovery of novel potent small-mol. II with high human NOP receptor selectivity over human μ receptor. The structure-activity relationship of the potency and selectivity, structure-metabolic stability relationship, and SAR of hERG (human ether-a-go-go related gene) potassium ion channel binding affinity for the analogs in the present studies in vitro provided significant and/or useful structural determinants and insights for the resp. purposes. The superior profiles of compound II were discussed with a viewpoint of multisite interactions between ligand and NOP receptor, together with the results of previous NOP receptor agonist/antagonist studies.
《Discovery of small-molecule nonpeptide antagonists of nociceptin/orphanin FQ receptor: The studies of design, synthesis, and structure-activity relationships for (4-arylpiperidine substituted-methyl)-[bicyclic (hetero)cycloalkanobenzene] derivatives》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2,3-Dihydrospiro[indene-1,4′-piperidine] hydrochloride)Synthetic Route of C13H18ClN.
Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem