Chemistry is traditionally divided into organic and inorganic chemistry. Safety of 5-Methylbenzo[d]oxazole-2(3H)-thione, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 22876-22-8
Synthesis of 2-substituted-N-[4-(1-methyl-4,5-diphenyl-1H-imidazole-2-yl) phenyl] acetamide derivatives and evaluation of theiranticancer activity
In the present study 18 novel imidazole-(benz)azole and imidazoleepiperazine derivatives were synthesized in order to investigate their probable anticancer activity. The structures of the compounds were confirmed by IR,1H NMR and EI-MS spectral data. Cytotoxicity (MTT),analysis of DNA synthesis and detection of apoptotic DNA assays were applied to determine anticancer activity of the compounds against colon (HT-29) and breast (MCF-7) carcinoma cell lines. Most of the compounds,showed greater activity against HT-29 cells than MCF-7 cells. Some of them indicated considerable cytotoxicity against both of the carcinogenic cell lines. However,their inhibitory activity on DNA synthesis was relatively poor. Anticancer activity screening results revealed that 11,12 and 13 were the most active compounds in the series. They exhibited significant cytotoxicity against both of the carcinogenic cell lines and caused DNA fragmentation of the HT-29 cells.
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Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem