So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic.Zhang, Xiaohui; Huang, Ruofeng; Marrot, Jerome; Coeffard, Vincent; Xiong, Yan researched the compound: 2-Ethylbenzo[d]oxazole( cas:6797-13-3 ).SDS of cas: 6797-13-3.They published the article 《Hypervalent iodine-mediated synthesis of benzoxazoles and benzimidazoles via an oxidative rearrangement》 about this compound( cas:6797-13-3 ) in Tetrahedron. Keywords: benzoxazole benzimidazole oxidative rearrangement preparation hypervalent iodine. We’ll tell you more about this compound (cas:6797-13-3).
A Beckmann-type rearrangement of o-hydroxy and o-aminoaryl N-H ketimines was developed to prepare benzoxazoles and N-Ts benzimidazoles, resp. The ketimine derivatives were easily prepared by condensation of ammonia with the corresponding ketones and (diacetoxyiodo)benzene acts as an efficient oxidant to trigger the [1,2]-aryl migration towards the formation of the desired heterocycles. Depending on the substitution pattern, the results revealed another mechanistic pathway through which benzisoxazoles or 1H-indazoles could be formed. The Beckmann-type rearrangement strategy was applied to the synthesis of benzimidazole-containing biorelevant targets such as chlormidazole and clemizole.
The article 《Hypervalent iodine-mediated synthesis of benzoxazoles and benzimidazoles via an oxidative rearrangement》 also mentions many details about this compound(6797-13-3)SDS of cas: 6797-13-3, you can pay attention to it, because details determine success or failure
Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem