1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.
Development of a catalyst-free, robust and straightforward iminocarbonylation protocol for the synthesis of N-acyl sulfoximines from sulfoximines and aryl iodides in the presence of Mo(CO)6 has been reported. Simple operation, broad substrate scope, wide functional group tolerance and excellent yields are the salient features of this work.
Molybdenumhexacarbonyl-Mediated Imino-Carbonylative Acylation of NH-Sulfoximines with Aryl Iodides. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem