Sodium dichloroiodate promoted C-C bond cleavage: An efficient synthesis of 1,3-benzazoles via condensation of o-amino/mercapto/hydroxyanilines with β-diketones was written by Bhagat, Saket B.;Ghodse, Shrikant M.;Telvekar, Vikas N.. And the article was included in Journal of Chemical Sciences (Berlin, Germany) in 2018.Electric Literature of C9H9NO This article mentions the following:
An efficient aqueous sodium dichloroiodate (NaICl2) mediated protocol is developed for the synthesis of benzo-fused azoles I (R1 = H, Me, Cl; R2 = Me, Et, i-Pr, Ph; X = NH, O, S) by the cyclization of 2-amino-substituted anilines, thiophenols or phenols 2-HX-5-R1C6H3NH2 with β-diketone compounds R2C(O)CH2C(O)R3 (R3 = Me, Et, i-Pr, Ph). The reactions gave moderate to good yield of the corresponding 2-substituted benzimidazoles, benzothiazoles or benzoxazoles, resp., under mild conditions. This tandem process involved a C-C bond cleavage and C-N bond formation. The reaction provides a rapid access to 1,3-benzazoles I in good yields, thus speeding up the drug discovery process. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Electric Literature of C9H9NO).
2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Being a heterocyclic compound, benzoxazole finds use in research as a starting material for the synthesis of larger, usually bioactive structures. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Electric Literature of C9H9NO
Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem