New discoveries in chemical research and development in 2021. Chemo-enzymatic cascade processes are invaluable due to their ability to rapidly construct high-value products from available feedstock chemicals. In an article, author is Erol, Meryem, once mentioned the application of 22439-61-8, Computed Properties of https://www.ambeed.com/products/22439-61-8.html, Name is 2-Bromodibenzo[b,d]thiophene, molecular formula is C12H7BrS, molecular weight is 263.15, MDL number is MFCD00089285, category is benzoxazole. Now introduce a scientific discovery about this category.
A series of some novel 2-(p-tert-butylphenyl)-5-(3-substituted-propionamido)benzoxazole derivatives have been designed, synthesized, evaluated for antimicrobial activity and have performed molecular docking studies against penicillin-binding protein 4 (PBP4) and active and allosteric site of PBP2a; were calculated some theoretical quantum parameters and absorption, distribution, metabolism and excretion (ADME) descriptors. B9 acted at minimum inhibitory concentration (MIC) = 8 mu g/mL against S. aureus, E. faecalis and their drug-resistant isolates and also formed with GLU145 (1.74 angstrom) and ILE144 (1.89 angstrom) two hydrogen bonds at allosteric site of PBP2a with Glide emodel score: -42.168. Delta E of compound B9 had moderate value of all compounds with 0.14742. Communicated by Ramaswamy H. Sarma
Interested yet? Read on for other articles about 22439-61-8, you can contact me at any time and look forward to more communication. Computed Properties of https://www.ambeed.com/products/22439-61-8.html.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem