With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59-49-4,2-Benzoxazolinone,as a common compound, the synthetic route is as follows.
To benzoxalinone (1.35 g, 1.00 mmol) in water (20 mL) was added NaOH (0.500 g, 1.25 mmol)and the mixture was stirred at room temperature until it became homogeneous. Dimethyl sulfate (1.51 g,1.20 mmol) was added dropwise to the mixture, and the reaction mixture was stirred rapidly at roomtemperature until precipitation was observed. Then, the reaction mixture was stirred for additional 2 h.The reaction mixture was neutralized with 1 M HCl, and the precipitate was collected by filtration anddried over P2O5 under vacuum to afford 2 as a light brown solid (1.162 g, 78%): 1H NMR (300 MHz,CDCl3) delta 7.34 – 7.07 (m, 3H), 6.99 (d, J = 7.3 Hz, 1H), 3.43 (s, 3H). The data were consistent withliterature values., 59-49-4
59-49-4 2-Benzoxazolinone 6043, abenzoxazole compound, is more and more widely used in various fields.
Reference£º
Article; Zhou, Yuchen; McGillick, Brian E.; Teng, Yu-Han Gary; Haranahalli, Krupanandan; Ojima, Iwao; Swaminathan, Subramanyam; Rizzo, Robert C.; Bioorganic and Medicinal Chemistry; vol. 24; 20; (2016); p. 4875 – 4889;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem