One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Formula: C8H6ClNO, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 41014-43-1, Name is 2-(Chloromethyl)benzo[d]oxazole, molecular formula is C8H6ClNO
Structure-based development of nitroxoline derivatives as potential multifunctional anti-Alzheimer agents
Tremendous efforts have been dedicated to the development of effective therapeutics against Alzheimer’s disease, which represents the most common debilitating neurodegenerative disease. Multifunctional agents are molecules designed to have simultaneous effects on different pathological processes. Such compounds represent an emerging strategy for the development of effective treatments against Alzheimer’s disease. Here, we report on the synthesis and biological evaluation of a series of nitroxoline-based analogs that were designed by merging the scaffold of 8-hydroxyquinoline with that of a known selective butyrylcholinesterase inhibitor that has promising anti-Alzheimer properties. Most strikingly, compound 8g inhibits self-induced aggregation of the amyloid beta peptide (Abeta1-42), inhibits with sub-micromolar potency butyrylcholinesterase (IC50 = 215 nM), and also selectively complexes Cu2+. Our study thus designates this compound as a promising multifunctional agent for therapeutic treatment of Alzheimer’s disease. The crystal structure of human butyrylcholinesterase in complex with compound 8g is also solved, which suggests ways to further optimize compounds featuring the 8-hydroxyquinoline scaffold.
Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Formula: C8H6ClNO, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 41014-43-1, in my other articles.
Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem