Related Products of 6674-22-2, Children learn through play, and they learn more than adults might expect. Science experiments are a great way to spark their curiosity, 6674-22-2, Name is 2,3,4,6,7,8,9,10-Octahydropyrimido[1,2-a]azepine, SMILES is N12C(CCCCC2)=NCCC1, belongs to benzoxazole compound. In a article, author is Vodnala, Nagaraju, introduce new discover of the category.
Facile Protocols towards C2-Arylated Benzoxazoles using Fe(III)-Catalyzed C(sp(2)-H) Functionalization and Metal-Free Domino Approach
Considering their growing attention in the field of medicinal chemistry and drug-discovery research, the facile and convenient approaches towards the preparation of 2-aryl benzoxazole derivatives have been described. The transformation is accomplished by using Fe(III)-catalyzed C-H activation of benzoxazoles with boronic acids to obtain a wide range of C2-arylated benzoxazoles in high yields. The developed method excludes the formation of self-coupling compounds as side products. On the other hand, the synthesis of the products is also achieved via a metal-free domino protocol by the reaction between 1-nitroso-2-naphthol and acetophenones using catalytic amounts of CBr4 in the presence of Cs2CO3 as base. The devised tandem method avoids the use of pre-activated alpha-haloketones as substrates. Due to their immense impact in marketed drugs and molecules under clinical trial, the described method can be a powerful tool for their synthesis which restricts the use of precious metals as catalyst.
Related Products of 6674-22-2, Each elementary reaction can be described in terms of its molecularity, the number of molecules that collide in that step. The slowest step in a reaction mechanism is the rate-determining step.you can also check out more blogs about 6674-22-2.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem