504-02-9, Name is Cyclohexane-1,3-dione, molecular formula is C6H8O2, belongs to benzoxazole compound, is a common compound. In a patnet, author is Wang, Weiwei, once mentioned the new application about 504-02-9, COA of Formula: C6H8O2.
Development of novel NLRP3-XOD dual inhibitors for the treatment of gout
Gout is a crystalline-related arthropathy caused by the deposition of monosodium urate (MSU). Acute gouty arthritis is the most common first symptom of gout. Studies have shown that NOD-like receptor protein 3 (NLRP3) inflammasome as pattern recognition receptors can be activated by uric acid crystallization, triggering immune inflammation and causing acute gouty arthritis symptoms. Currently, the treatment of gout mainly includes two basic methods: reducing uric acid and alleviating inflammation. In this paper, 22 novel benzoxazole and benzimidazole derivatives were synthesized from deoxybenzoin oxime derivatives. These compounds have good inhibitory effects on NLRP3 and XOD screened by our research group in the early stage. The inhibitory activities of XOD and NLRP3 and their derivatives were also screened. Notably, compound 9b is a multi-targeting inhibitor of NLRP3 and XOD with excellent potency in treating hyperuricemia and acute gouty arthritis.
We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 504-02-9. The above is the message from the blog manager. COA of Formula: C6H8O2.
Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem