Category: 1086378-35-9

Hansen, Martin et al. published their research in Bioorganic & Medicinal Chemistry in 2015 |CAS: 1086378-35-9

The Article related to bromodimethoxy phenethyl amine preparation 5ht2a 5ht2c agonist, 5-ht(2a) agonists, n-benzyl phenethylamines, selectivity, serotonin, structure activity relations, Pharmacology: Structure-Activity and other aspects.Formula: C9H7NO3

On July 15, 2015, Hansen, Martin; Jacobsen, Stine Engesgaard; Plunkett, Shane; Liebscher, Gudrun Eckhard; McCorvy, John D.; Brauner-Osborne, Hans; Kristensen, Jesper Langgaard published an article.Formula: C9H7NO3 The title of the article was Synthesis and pharmacological evaluation of N-benzyl substituted 4-bromo-2,5-dimethoxyphenethylamines as 5-HT2A/2C partial agonists. And the article contained the following:

N-Benzyl substitution of phenethylamine 5-HT2A receptor agonists has dramatic effects on binding affinity, receptor selectivity and agonist activity. In this paper we examine how affinity for the 5-HT2A/2C receptors are influenced by N-benzyl substitution of 4-bromo-2,5-dimethoxyphenethylamine derivatives Special attention is given to the 2′ and 3′-position of the N-benzyl as such compounds are known to be very potent. We found that substitutions in these positions are generally well tolerated. The 2′-position was further examined using a range of substituents to probe the hydrogen bonding requirements for optimal affinity and selectivity, and it was found that small changes in the ligands in this area had a profound effect on their affinities. Furthermore, two ligands that lack a 2′-benzyl substituent were also found to have high affinity contradicting previous held notions. Several high-affinity ligands were identified and assayed for functional activity at the 5-HT2A and 5-HT2C receptor, and they were generally found to be less efficacious agonists than previously reported N-benzyl phenethylamines. The experimental process involved the reaction of Methyl benzo[d]oxazole-7-carboxylate(cas: 1086378-35-9).Formula: C9H7NO3

The Article related to bromodimethoxy phenethyl amine preparation 5ht2a 5ht2c agonist, 5-ht(2a) agonists, n-benzyl phenethylamines, selectivity, serotonin, structure activity relations, Pharmacology: Structure-Activity and other aspects.Formula: C9H7NO3

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Mete, Antonio et al. published their patent in 2020 |CAS: 1086378-35-9

The Article related to heterocyclic arh modulator signaling cancer, Pharmaceuticals: Formulation and Compounding and other aspects.Safety of Methyl benzo[d]oxazole-7-carboxylate

On March 5, 2020, Mete, Antonio; Hitchin, James R.; Graham, Mark published a patent.Safety of Methyl benzo[d]oxazole-7-carboxylate The title of the patent was Heterocyclic compounds as ARH modulators for treatment of diseases, in particular cancer. And the patent contained the following:

The present invention relates compounds of the general formula (I) or (II) which are ARH inhibitors, methods for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds and pharmaceutical compositions for the treatment or prevention of diseases, in particular cancer or conditions with dysregulated immune functions, or other conditions associated with aberrant AHR signaling, as a sole agent of in combination with other active ingredients. Such compounds may also be of utility in the expansion of hematopoietic stem cells (HSCs) and the use of HSCs in autologous or allogenic transplantation for the treatment of patients with inherited immunol. and autoimmune diseases and diverse hematopoietic disorders. The experimental process involved the reaction of Methyl benzo[d]oxazole-7-carboxylate(cas: 1086378-35-9).Safety of Methyl benzo[d]oxazole-7-carboxylate

The Article related to heterocyclic arh modulator signaling cancer, Pharmaceuticals: Formulation and Compounding and other aspects.Safety of Methyl benzo[d]oxazole-7-carboxylate

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Sasmal, Swarnendu et al. published their research in Tetrahedron Letters in 2015 |CAS: 1086378-35-9

The Article related to arylation benzoxazole iodoanilide copper palladium catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Computed Properties of 1086378-35-9

On March 11, 2015, Sasmal, Swarnendu; Sen, Indira; Hall, Roger G.; Pal, Sitaram published an article.Computed Properties of 1086378-35-9 The title of the article was Intermolecular coupling of 2-iodoanilides with benzoxazoles: synthesis of N-(2-benzoxazol-2-ylphenyl)benzamides via C-H activation. And the article contained the following:

Using CuI/xantphos/Pd(OAc)2 catalytic system, the intermol. C-C cross-coupling between benzoxazoles and o-iodoanilides has been developed in moderate to good yields. The procedure tolerates a series of functional groups on benzoxazole, such as ester, chloro, Me, and methoxy groups. This divergent approach provides access to various N-(2-benzoxazol-2-ylphenyl)amides. The experimental process involved the reaction of Methyl benzo[d]oxazole-7-carboxylate(cas: 1086378-35-9).Computed Properties of 1086378-35-9

The Article related to arylation benzoxazole iodoanilide copper palladium catalyst, Heterocyclic Compounds (More Than One Hetero Atom): Oxazoles, Isoxazoles and other aspects.Computed Properties of 1086378-35-9

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Ono, Masahiro et al. published their patent in 2016 |CAS: 1086378-35-9

The Article related to aromatic heterocycle preparation znf143 inhibitor, cancer treatment aromatic heterocycle znf143 inhibition, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Name: Methyl benzo[d]oxazole-7-carboxylate

On July 11, 2016, Ono, Masahiro; Kobayashi, Tsuneyuki; Yamazaki, Ryuta; Haibara, Hirotaka; Nishiyama, Yukiko; Hohashi, Atsuko; Nishiyama, Hiroyuki; Kurita, Akinari; Matsuzaki, Takeshi; Kono, Kimitoshi; Izumi, Hiroto published a patent.Name: Methyl benzo[d]oxazole-7-carboxylate The title of the patent was Preparation of heteroaryl compounds as ZNF143 inhibitors. And the patent contained the following:

Title compounds A-B-C-D [A = H, CH3, naphthalen-1-yl, etc.; B = -CC-; C = -CONH-, -CON(CH3)- or 1,3,4-oxadiazole-2,5-diyl; D = (un)substituted Ph or monocyclic heteroaryl containing N or S; or C and D may combine to form (un)substituted benzoxazol-2-yl, benzothiazol-2-yl, benzimidazol-2-yl, etc.; or salts thereof], useful for the treatment of cancer, were prepared For example, to a suspension of 3-phenylpropiolic acid (1.27 mmol) in CH2Cl2 (1.9 mL) were added oxalyl chloride (1.33 mmol) and DMF (1 drop), the resulting mixture was stirred at room temperature for 2 h and treated with 2-amino-4-chlorobenzonitrile (1.27 mmol) [room temperature, overnight] to give, after work-up, compound I (75.2% yield). The invention compounds, e.g., II, showed selective inhibition activity for ZNF143 over SV40 promotor. The experimental process involved the reaction of Methyl benzo[d]oxazole-7-carboxylate(cas: 1086378-35-9).Name: Methyl benzo[d]oxazole-7-carboxylate

The Article related to aromatic heterocycle preparation znf143 inhibitor, cancer treatment aromatic heterocycle znf143 inhibition, Heterocyclic Compounds (More Than One Hetero Atom): Pyrazines and Quinoxalines (Including Piperazines) and other aspects.Name: Methyl benzo[d]oxazole-7-carboxylate

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Analyzing the synthesis route of 1086378-35-9

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Methyl benzo[d]oxazole-7-carboxylate, 1086378-35-9

1086378-35-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Methyl benzo[d]oxazole-7-carboxylate, cas is 1086378-35-9,the benzoxazole compound, it is a common compound, a new synthetic route is introduced below.

A solution of methyl benzo[d]oxazole-7-carboxylate (0.5 g, 2.82 mmol), 1-iodo-4-nitrobenzene (0.88 g, 3.53 mmol), lithium tert-butoxide (0.45 g, 5.64 mmol), tetrakis(triphenyl phosphine)palladium(0) (0.16 g, 0.141 mmol) in dioxane under a nitrogen atmosphere was stirred at room temperature for 45 minutes. The resulting thick suspension was diluted with EtOAc, washed with water, organics washed with brine, dried over Na2SO4, decanted and solvent removed under vacuum. The crude was purified by column chromatography on silica gel using 20:1 to 5:1 Hexane:EtOAc as eluent to give methyl 2-(4-nitrophenyl)benzo[d]oxazole-7-carboxylate (0.4 g, 48%). UPLC-MS (Acidic Method, 2 min): rt 1.11 min, m/z 299.0 [M+H]+

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Methyl benzo[d]oxazole-7-carboxylate, 1086378-35-9

Reference：
Patent; JAGUAHR THERAPEUTICS PTE LTD; METE, Antonio; HITCHIN, James, R.; GRAHAM, Mark; (46 pag.)WO2020/43880; (2020); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Analyzing the synthesis route of 1086378-35-9

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Methyl benzo[d]oxazole-7-carboxylate, 1086378-35-9

1086378-35-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Methyl benzo[d]oxazole-7-carboxylate, cas is 1086378-35-9,the benzoxazole compound, it is a common compound, a new synthetic route is introduced below.

General procedure: To a degassed solution (N2 was purged for 10 min) of methyl 1,3-benzoxazole-4-carboxylate (150 mg, 0.847mmol) and N-(2-iodophenyl)benzamide 2a (273 mg, 0.847 mmol) in anhydrous toluene (4ml) , CuI (32 mg, 0.169 mmol), xantphos (98 mg, 0.169 mmol), Pd(OAc)2 (10 mg, 0.042 mmol), Cs2CO3 (685 mg, 2.117 mmol) were added at room temperature under nitrogen atmosphere. Reaction mixture was continued for 20 hours at reflux condition. After the completetion of the reaction (monitored by TLC), Reaction mixture was filtered through celite bed and washed with methanol (10 ml),filtrate was concentrated. Crude mass which was purified by column chromatography over silica gel (230-400 mesh) using DCM-Methanol (1:9) as elutant to affordthe products 3a (284 mg) as white solid. All the other compounds 3b-3r were prepared similarly following the above procedure.

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of Methyl benzo[d]oxazole-7-carboxylate, 1086378-35-9

Reference：
Article; Sasmal, Swarnendu; Sen, Indira; Hall, Roger G.; Pal, Sitaram; Tetrahedron Letters; vol. 56; 11; (2015); p. 1374 – 1377;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

The important role of 1086378-35-9

The chemical industry reduces the impact on the environment during synthesis,1086378-35-9,Methyl benzo[d]oxazole-7-carboxylate,I believe this compound will play a more active role in future production and life.

1086378-35-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Methyl benzo[d]oxazole-7-carboxylate, cas is 1086378-35-9,the benzoxazole compound, it is a common compound, a new synthetic route is introduced below.

Methyl benzo[d]oxazole-7-carboxylate (1.57 g, 8.86 mmol) was dissolved in dry THF (50 mL) and there was added a 1.0M solution of LiAlH4 in THF (5mL, 5 mmol). The reaction was stirred at room temperature for 30 minutes at which point TLC indicated full conversion. The reaction was quenched by addition of water (50 mL) and there was added saturated aqueous Rochelle salt (50 mL) and Et2O (50 mL). The reaction was stirred vigorously for 15 minutes and then transferred to a separatory funnel. The organic layer was isolate and the aqueous layer was extracted with Et2O (2 × 100 mL). The combined organic layers were washed with saturated aqueous Rochelle salt (50 mL) and water (50 mL), dried (MgSO4), filtered and evaporated under reduced pressure. The crude compound was purified by flash chromatography (petroleum ether/EtOAc 3:1) to give the title compound (0.823 g, 62%) as a colorless oil. 1H NMR (300 MHz, CDCl3) delta 8.07 (s, 1H), 7.69 (dd, J = 7.7, 1.3 Hz, 1H), 7.40 (dd, J = 7.7, 1.3 Hz, 1H), 7.33 (t, J = 7.7 Hz), 5.00 (s, 2H), 2.51 (br s, 1H). 13C NMR (75 MHz, CDCl3) delta 153.4, 145.4, 140.0, 124.8, 124.7, 124.4, 119.9, 60.3

The chemical industry reduces the impact on the environment during synthesis,1086378-35-9,Methyl benzo[d]oxazole-7-carboxylate,I believe this compound will play a more active role in future production and life.

Reference：
Article; Hansen, Martin; Jacobsen, Stine Engesgaard; Plunkett, Shane; Liebscher, Gudrun Eckhard; McCorvy, John D.; Braeuner-Osborne, Hans; Kristensen, Jesper Langgaard; Bioorganic and Medicinal Chemistry; vol. 23; 14; (2015); p. 3933 – 3937;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Application of 6-Bromobenzo[d]oxazol-2(3H)-one

The chemical industry reduces the impact on the environment during synthesis,1086378-35-9,Methyl benzo[d]oxazole-7-carboxylate,I believe this compound will play a more active role in future production and life.

1086378-35-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Methyl benzo[d]oxazole-7-carboxylate, cas is 1086378-35-9,the benzoxazole compound, it is a common compound, a new synthetic route is introduced below.

The compound obtained in Example 51-2 (1.221 g, 6.89 mmol) and THF (24 ml), was dissolved in ethanol (24 ml), cooled with ice. Thereto calcium chloride (1.529 g, 13.78 mmol), sodium borohydride (1.043 g, 27.56 mmol) was stirred at room temperature for 2 hours added. After the reaction was extracted with ethyl acetate by adding 1 mol / l hydrochloric acid. It was washed with a saturated aqueous sodium bicarbonate solution. Dried with magnesium sulfate, and the solvent was evaporated. The residue was purified by silica gel column chromatography (SNAP ULTRA 25 g, hexane / ethyl acetate) to give the title compound (149 mg, 14.5%) as a white solid.

The chemical industry reduces the impact on the environment during synthesis,1086378-35-9,Methyl benzo[d]oxazole-7-carboxylate,I believe this compound will play a more active role in future production and life.

Reference：
Patent; Yakult Honsha Co., Ltd.; University of Occupational and Environmental Health; Ono, Masahiro; Kobayashi, Tsuneyuki; Yamazaki, Ryuta; Haibara, Hirotake; Nishiyama, Yukiko; Hokkyo, Atsuko; Nishiyama, Hiroyuki; Kurita, Akinobu; Matsuzaki, Ken; Kono, Kimitoshi; Izumi, Hiroto; (215 pag.)JP2016/124812; (2016); A;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Extracurricular laboratory: Synthetic route of 1086378-35-9

The chemical industry reduces the impact on the environment during synthesis,1086378-35-9,Methyl benzo[d]oxazole-7-carboxylate,I believe this compound will play a more active role in future production and life.

1086378-35-9, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Methyl benzo[d]oxazole-7-carboxylate, cas is 1086378-35-9,the benzoxazole compound, it is a common compound, a new synthetic route is introduced below.

A solution of methyl benzo[d]oxazole-7-carboxylate (300 mg, 1.7 mmol) in THF (5 mL) was cooled down to 0C and methyl magnesium bromide 3.2M in 2-Me-THF (3.0 equiv., 5.1 mmol) was added dropwise. The mixture was allowed to warm-up to room temperature and quenched with saturated solution of NH4Cl. The resulting mixture was extracted 3 times with EtOAc and the organic solutions were washed with brine, dried with Na2SO4 and concentrated to dryness. The crude was purified by column chromatography on silica gel using DCM:EtOAc (95:5) as mobile phase to give 2-(benzo[d]oxazol-7-yl)propan-2-ol (110 mg, 37%). UPLC-MS (Acidic Method, 2 min): rt 0.78 min, m/z 178.0 [M+H]+

The chemical industry reduces the impact on the environment during synthesis,1086378-35-9,Methyl benzo[d]oxazole-7-carboxylate,I believe this compound will play a more active role in future production and life.

Reference：
Patent; JAGUAHR THERAPEUTICS PTE LTD; METE, Antonio; HITCHIN, James, R.; GRAHAM, Mark; (46 pag.)WO2020/43880; (2020); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Final Thoughts on Chemistry for Methyl benzo[d]oxazole-7-carboxylate

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1086378-35-9

Reference of 1086378-35-9, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1086378-35-9, Name is Methyl benzo[d]oxazole-7-carboxylate, molecular formula is C9H7NO3. In a Patent£¬once mentioned of 1086378-35-9

2,6-dialkyl-4-(benzothiazol- or benzoxazol-4-yl-1,4-dihydropyridines

2,6-dialkyl-4-(benzothiazol- or benzoxazol-7-yl)-1,4-dihydropyridines which exhibit positive inotropic action with largely neutral vascular behavior, of the formula STR1 in which R1 and R5 are identical or different and represent straight-chain or branched alkyl having up to 8 carbon atoms, R2 represents nitro or cyano, or R1 and R2 together form a lactone ring of the formula STR2 R3 represents a radical of the formula STR3 R4 -R7 are defined hereinafter and physiologically acceptable salts thereof.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 1086378-35-9

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem