Category: 1267217-46-8

As a common heterocyclic compound, it belongs to benzoxazole compound, name is 5-(Trifluoromethyl)benzo[d]oxazole, and cas is 1267217-46-8, its synthesis route is as follows.

General procedure: In a two-necked flask equipped with a reflux condenser were placed RhH(PPh3)4 (4 mol%, 11.5 mg), 1,2-bis(diphenylphosphino)ethane (8 mol%, 8.0 mg), 1,3-benzothiazole 5 (0.25 mmol, 27.3 mL), and (alpha-phenylthio)isobutyrophenone 6 (0.25 mmol, 64.0 mg) in chlorobenzene (0.25 mL) under an argon atmosphere, and the solution was heated at reflux for 3 h. The mixture was purified by flash column chromatography on silica gel giving 7 (55.8 mg, 92%) and isobutyrophenone 8 (34.3 mg, 93%) with the recovery of 5 (3.5 mg, 10%) and 6 (0.8 mg, 1%).

1267217-46-8, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,1267217-46-8 ,5-(Trifluoromethyl)benzo[d]oxazole, other downstream synthetic routes, hurry up and to see

Reference：
Article; Arisawa, Mieko; Toriyama, Fumihiko; Yamaguchi, Masahiko; Tetrahedron Letters; vol. 52; 18; (2011); p. 2344 – 2347;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

1267217-46-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 5-(Trifluoromethyl)benzo[d]oxazole, cas is 1267217-46-8,the benzoxazole compound, it is a common compound, a new synthetic route is introduced below.

To a solution of 5-(trifluoromethyl)benzo[d]oxazole (2g, 10.98mmol) in dry THF (2OmL) was added LiHMDS (6 mL, 1 M in THF, 32.96mmol) at -10 00 slowly. The reaction mixture was stirred at -10 00 for 30 mm and added NBS (2.8g, 16.48mmol). The reaction mixture was allowed to come to rt and stirred for 16h. The TLC showed reaction to be complete. The reaction mixture was quenched with aq NH4CI solution (5OmL) and extracted with ethyl acetate (3x5OmL). The organic layer was washed with saturated aq NaHCO3 solution (5OmL) followed by brine (5OmL), dried (Na2SO4), filtered and concentrated under reduced pressure to give the residue. The residue was purified by column chromatography using silica gel (100-200 mesh), eluting with 3% EtOAc in hexane to afford 2-bromo-5- (trifluoromethyl)benzo[d]oxazole as a white solid. Yield: 900 mg (32%); 1H NMR (400 MHz, CDCI3): 7.99 (5, 1H), 759-7.69 (m, 2H).

Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 5-(Trifluoromethyl)benzo[d]oxazole, 1267217-46-8

Reference：
Patent; DISCUVA LTD.; MEO, Dr Paul; KHAN, Dr. Nawaz; (284 pag.)WO2018/37223; (2018); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Application of 1267217-46-8, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.1267217-46-8, Name is 5-(Trifluoromethyl)benzo[d]oxazole, molecular formula is C8H4F3NO. In a article£¬once mentioned of 1267217-46-8

Palladium-catalyzed direct arylation of benzoxazoles with unactivated simple arenes

Using CuBr2 as an additive, the Pd-catalyzed intermolecular C-H-C-H cross-coupling between benzoxazoles and unactivated simple arenes has been developed. This protocol provides a straightforward approach for the biological activity of 2-arylbenzoxazole derivatives.

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Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Reference of 1267217-46-8, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.1267217-46-8, Name is 5-(Trifluoromethyl)benzo[d]oxazole, molecular formula is C8H4F3NO. In a article£¬once mentioned of 1267217-46-8

CuCl-Catalyzed direct C-H alkenylation of benzoxazoles with allyl halides

An efficient and concise CuCl-catalyzed C2-alkenylation reaction of benzoxazoles with allyl halides has been established. The distinctive features of this protocol include the use of an inexpensive copper salt as a catalyst, simple and readily available starting materials, and ligand-free conditions. An important application of this method to the synthesis of 1,3-diene substituted benzoxazoles has also been achieved.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

1267217-46-8, Name is 5-(Trifluoromethyl)benzo[d]oxazole, belongs to benzoxazole compound, is a common compound. Computed Properties of C8H4F3NOIn an article, once mentioned the new application about 1267217-46-8.

Ytterbium(III) Trifluoromethanesulfonate Catalyzed Ring-Opening C(sp3)?N Bond Formation of Benzoxazoles with Propargylic Alcohols

A novel ytterbium(III) trifluoromethanesulfonate [Yb(OTf)3]-catalyzed ring-opening C(sp3)?N bond formation reaction of benzoxazole with propargylic alcohols was established. This reaction uses readily available starting materials and is operationally simple; it thus represents a practical method for the construction of highly functionalized substituted benzenes bearing aldehyde, propargylamine, and hydroxy groups with high atom economy.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Application of 1267217-46-8, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.1267217-46-8, Name is 5-(Trifluoromethyl)benzo[d]oxazole, molecular formula is C8H4F3NO. In a article£¬once mentioned of 1267217-46-8

ZNF143 inhibition activity and compd. utilizing the same (by machine translation)

PROBLEM TO BE SOLVED: ZNF143 inhibition effect compd. ZNF143 inhibitor and containing the same and a pharmaceutical composition. SOLUTION: eq. (I) or a salt thereof and a compound containing an active component and a and ZNF143 inhibitor. A-B-C-D (I) [A is H, a methyl group, a naphthyl group, a phenyl group or a nitrogen-containing heterocycle; B comprises, And, the C, or N and O ring containing an amide bond; D is a substituted or unsubstituted phenyl group including a single ring or a ring of N or S; C and D are both, may have a substituent, a condensed heterocyclic ring, etc.] selected drawing: fig. 1 (by machine translation)

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Reference of 1267217-46-8, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.1267217-46-8, Name is 5-(Trifluoromethyl)benzo[d]oxazole, molecular formula is C8H4F3NO. In a Article£¬once mentioned of 1267217-46-8

Unexpected TFA-catalyzed tandem reaction of benzo[d]oxazoles with 2-oxo-2-arylacetic acids: Synthesis of 3-aryl-2H-benzo[b][1,4]oxazin-2-ones and cephalandole A

A convenient and efficient method for the TFA-catalyzed synthesis of 3-aryl-2H-benzo[b][1,4]oxazin-2-ones via a tandem reaction of benzo[d]oxazoles with 2-oxo-2-arylacetic acids was reported for the first time. The efficiency of this transformation was demonstrated by compatibility with a wide range of functional groups. The synthetic utility of this method was confirmed by the synthesis of the natural product cephalandole A. Moreover, a plausible mechanism for the formation of 3-aryl-2H-benzo[b][1,4]oxazin-2-ones involving ring-opening and cyclization steps is proposed. The present synthetic route to 3-aryl-2H-benzo[b][1,4]oxazin-2-ones could be readily scaled up to gram quantity without difficulty.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Chemistry is traditionally divided into organic and inorganic chemistry. Product Details of 1267217-46-8, The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 1267217-46-8

Rhodium-catalyzed phenylthiolation reaction of heteroaromatic compounds using alpha-(phenylthio)isobutyrophenone

In the presence of catalytic amounts of RhH(PPh3)4 and 1,2-bis(diphenylphosphino)ethane (dppe), 1,3-benzothiazoles, 1,3-benzoxazoles, and benzothiophene reacted with alpha-(phenylthio) isobutyrophenone giving 2-phenylthio derivatives. Reactive monocyclic heteroaromatics, 1-methyl-1,2,3,4-tetrazole and 2-cyanothiophene were also converted into the 5-phenylthio derivatives. The use of an appropriate phenylthio transfer reagent is crucial for the efficient catalyzed conversion of heteroaromatic C-H bonds into C-S bonds.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Reference of 1267217-46-8, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 1267217-46-8, molcular formula is C8H4F3NO, introducing its new discovery.

ANTIBIOTIC COMPOUNDS

The present invention relates to antibiotic compounds of formula (I), to compositions containing these compounds and to methods of treating bacterial diseases and infections using the compounds. The compounds find application in the treatment of infection with, and diseases caused by, Gram-positive and/or Gram-negative bacteria, and in particular in the treatment of infection with, and diseases caused by, Neisseria gonorrhoeae.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 1267217-46-8 is helpful to your research. Reference of 1267217-46-8

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1267217-46-8,5-(Trifluoromethyl)benzo[d]oxazole,as a common compound, the synthetic route is as follows.

To a solution of 5-(trifluoromethyl)benzo[d]oxazole (2g, 10.98mmol) in dry THF (2OmL) was added LiHMDS (6 mL, 1 M in THF, 32.96mmol) at -10 00 slowly. The reaction mixture was stirred at -10 00 for 30 mm and added NBS (2.8g, 16.48mmol). The reaction mixture was allowed to come to rt and stirred for 16h. The TLC showed reaction to be complete. The reaction mixture was quenched with aq NH4CI solution (5OmL) and extracted with ethyl acetate (3x5OmL). The organic layer was washed with saturated aq NaHCO3 solution (5OmL) followed by brine (5OmL), dried (Na2SO4), filtered and concentrated under reduced pressure to give the residue. The residue was purified by column chromatography using silica gel (100-200 mesh), eluting with 3% EtOAc in hexane to afford 2-bromo-5- (trifluoromethyl)benzo[d]oxazole as a white solid. Yield: 900 mg (32%); 1H NMR (400 MHz, CDCI3): 7.99 (5, 1H), 759-7.69 (m, 2H).

1267217-46-8, The synthetic route of 1267217-46-8 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; DISCUVA LTD.; MEO, Dr Paul; KHAN, Dr. Nawaz; (284 pag.)WO2018/37223; (2018); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem