Category: 1267217-46-8

Brief introduction of 1267217-46-8

1267217-46-8 5-(Trifluoromethyl)benzo[d]oxazole 21749513, abenzoxazole compound, is more and more widely used in various fields.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.1267217-46-8,5-(Trifluoromethyl)benzo[d]oxazole,as a common compound, the synthetic route is as follows.

General procedure: In a two-necked flask equipped with a reflux condenser were placed RhH(PPh3)4 (4 mol%, 11.5 mg), 1,2-bis(diphenylphosphino)ethane (8 mol%, 8.0 mg), 1,3-benzothiazole 5 (0.25 mmol, 27.3 mL), and (alpha-phenylthio)isobutyrophenone 6 (0.25 mmol, 64.0 mg) in chlorobenzene (0.25 mL) under an argon atmosphere, and the solution was heated at reflux for 3 h. The mixture was purified by flash column chromatography on silica gel giving 7 (55.8 mg, 92%) and isobutyrophenone 8 (34.3 mg, 93%) with the recovery of 5 (3.5 mg, 10%) and 6 (0.8 mg, 1%)., 1267217-46-8

1267217-46-8 5-(Trifluoromethyl)benzo[d]oxazole 21749513, abenzoxazole compound, is more and more widely used in various fields.

Reference£º
Article; Arisawa, Mieko; Toriyama, Fumihiko; Yamaguchi, Masahiko; Tetrahedron Letters; vol. 52; 18; (2011); p. 2344 – 2347;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Introduction of a new synthetic route about 1267217-46-8

With the rapid development of chemical substances, we look forward to future research findings about 1267217-46-8

5-(Trifluoromethyl)benzo[d]oxazole, cas is 1267217-46-8, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,1267217-46-8

General procedure: In a two-necked flask equipped with a reflux condenser were placed RhH(PPh3)4 (4 mol%, 11.5 mg), 1,2-bis(diphenylphosphino)ethane (8 mol%, 8.0 mg), 1,3-benzothiazole 5 (0.25 mmol, 27.3 mL), and (alpha-phenylthio)isobutyrophenone 6 (0.25 mmol, 64.0 mg) in chlorobenzene (0.25 mL) under an argon atmosphere, and the solution was heated at reflux for 3 h. The mixture was purified by flash column chromatography on silica gel giving 7 (55.8 mg, 92%) and isobutyrophenone 8 (34.3 mg, 93%) with the recovery of 5 (3.5 mg, 10%) and 6 (0.8 mg, 1%).

With the rapid development of chemical substances, we look forward to future research findings about 1267217-46-8

Reference£º
Article; Arisawa, Mieko; Toriyama, Fumihiko; Yamaguchi, Masahiko; Tetrahedron Letters; vol. 52; 18; (2011); p. 2344 – 2347;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem