Category: 1268137-13-8

On January 20, 2016, Lee, Ha-Rim; Farhanullah; Lee, JiSoo; Jajoo, Rahul; Kong, Sun-Young; Shin, Jae-Yeon; Kim, Jae-Ouk; Lee, Jiyoun; Lee, Jeewoo; Kim, Hyun-Jung published an article.Recommanded Product: 1268137-13-8 The title of the article was Discovery of a Small Molecule that Enhances Astrocytogenesis by Activation of STAT3, SMAD1/5/8, and ERK1/2 via Induction of Cytokines in Neural Stem Cells. And the article contained the following:

Identification of small mols. that direct neural stem cells (NSCs) into specific cell types would be helpful to understand the mol. mechanisms involved in regulation of NSC fate, and facilitate the development of therapeutic applications. In the current study, we developed and screened small mols. that can modulate the fate of NSCs that are derived from rat fetal cortex. Among these compounds, compounds 5 and 6 successfully differentiated NSCs into astrocytes and neurons, resp. Compound 5 induced astrocytogenesis by increasing expression of interleukin-6, bone morphogenetic protein 2 and leukemia inhibitory factor and through consequent phosphorylation of signal transducer and activator of transcription 3 and Sma- and Mad-related protein 1/5/8 in NSCs. In addition, compound 5 increased the expression of fibroblast growth factor (FGF) 2 and FGF8 which may regulate the branching and morphol. of astrocytes. Taken together, our results suggest that these small mols. can serve as a useful tool to study cell fate determination in NSCs and be used as an inexpensive alternative to cytokines to study mechanisms of astrocytogenesis. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Recommanded Product: 1268137-13-8

The Article related to benzothiazole derivative preparation structure activity astrocytogenesis stat3 smad erk, astrocytogenesis, differentiation, neural stem cells, neurodegeneration, neurological agents, structure−activity relationships and other aspects.Recommanded Product: 1268137-13-8

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On November 15, 2021, Jie, liu; Ye, Wan; Xu, Jiang-Ping; Wang, Hai-Tao; Li, Xiao-Fang; Wang, Wen-Ya; Zhou, Zhong-Zhen published an article.Category: benzoxazole The title of the article was Discovery of novel trimethoxyphenylbenzo[d]oxazoles as dual tubulin/PDE4 inhibitors capable of inducing apoptosis at G2/M phase arrest in glioma and lung cancer cells. And the article contained the following:

To discover PDE4/tubulin dual inhibitors with novel skeleton structures, 7-trimethoxyphenylbenzo[d]oxazoles I [R1 = R2 = H, MeO; R3 = C6H5, 4-MeO-C6H4, 3-F-C6H4, etc] and 4-trimethoxyphenylbenzo[d]oxazoles II [R4 = C6H5, 3,4-MeO-C6H3, 4-F-C6H4, etc] were designed and synthesized by migrating the trimethoxyphenyl group of TH03 to the benzo[d]oxazole moiety. Among these compounds, approx. half of them displayed good antiproliferative activities against glioma (U251) and lung cancer (A549 and H460) cell lines. The structure-activity relationships of trimethoxyphenylbenzo[d]oxazoles led to the identification of I [R1 = H; R2 = MeO; R3 = 1H-indol-5-yl] bearing indol-5-yl side-chain as a novel dual PDE4/tubulin inhibitor, which exhibited satisfactory antiproliferative activities against glioma (IC50 = 300 ± 50 nM) and lung cancer (average IC50 = 39.5 nM) cells. Further investigations revealed that I [R1 = H; R2 = MeO; R3 = 1H-indol-5-yl] induced apoptosis at G2/M phase arrest and disrupted the microtubule network. The preliminary mechanism of action showed that I [R1 = H; R2 = MeO; R3 = 1H-indol-5-yl] down-regulated the expression of cyclin B1 and its upstream regulator gene cdc25C in A549. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Category: benzoxazole

The Article related to trimethoxyphenylbenzoxazole preparation tubulin inhibitor antiproliferative sar, antiproliferative activities, apoptosis, cell cycle arrest, dual pde4/tubulin inhibitor, trimethoxyphenylbenzo[d]oxazole and other aspects.Category: benzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On June 1, 2012, Wu, Mingyue; Hu, Xiong; Liu, Juan; Liao, Yunfeng; Deng, Guo-Jun published an article.Product Details of 1268137-13-8 The title of the article was Iron-Catalyzed 2-Arylbenzoxazole Formation from o-Nitrophenols and Benzylic Alcohols. And the article contained the following:

The iron-catalyzed 2-arylbenzoxazole formation from o-nitrophenols and benzylic alcs. using hydrogen transfer is described. Various 2-arylbenzoxazoles were selectively obtained in good to excellent yields. The reaction tolerated a wide range of functionalities. The alc. oxidation, nitro reduction, condensation, and dehydrogenation were realized in a cascade without external reducing reagent and oxidant. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Product Details of 1268137-13-8

The Article related to nitrophenol benzylic alc iron oxidation reduction condensation dehydrogenation cascade, arylbenzoxazole preparation, oxidation reduction condensation dehydrogenation cascade catalyst iron dppf and other aspects.Product Details of 1268137-13-8

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On October 6, 2020, Jung, Ho Yeong; Park, Yong Uk; Kim, Nam Su; Lee, Nam Geol published a patent.Recommanded Product: 7-Bromo-2-phenylbenzo[d]oxazole The title of the patent was Preparation of fluorene derivatives as organic electronic device materials. And the patent contained the following:

Disclosed are compounds I [R1 – R4 are independently H, deuterium, tritium, halo, cyano, nitro, (un)substituted aryl, (un)substituted fluorenyl, (un)substituted heterocyclyl, (un)substituted alicyclyl, (un)substituted alkyl, (un)substituted alkenyl, (un)substituted alkynyl, (un)substituted alkoxy, (un)substituted aryloxy, or N-(L1-Ar1)(L2-Ar2); at least one of R1 and R2 is N-(L1-Ar1)(L2-Ar2) and R3 and R4 may combine together with adjacent groups to form a ring; a and b are independently 0-4; L1 and L2 are independently single bond, (un)substituted arylene, (un)substituted fluorenylene, (un)substituted heterocyclylene, or (un)substituted alicyclylene; Ar1 and Ar2 are independently (un)substituted aryl, (un)substituted fluorenyl, (un)substituted heterocyclyl, or (un)substituted alicyclyl]. Example compound II was prepared by palladium-catalyzed cross-coupling reaction of N,9-diphenyl-9H-fluoren-9-amine with bromobenzene in 88% yield. Electroluminescent device comprising an invention compound showed improvements in efficiency, driving voltage, and life span compared to device using previously reported compound The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Recommanded Product: 7-Bromo-2-phenylbenzo[d]oxazole

The Article related to fluorene derivative preparation organic electronic device material, Benzene, Its Derivatives, and Condensed Benzenoid Compounds: Dibenzocyclobutenes, Acenaphthenes, Fluorenes, and Their Benzo Analogs, Such As Fluoranthenes and other aspects.Recommanded Product: 7-Bromo-2-phenylbenzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On May 4, 2017, Ahn, Hee-Choon; Cho, Sang-Hee published a patent.Related Products of 1268137-13-8 The title of the patent was Electron buffering materials, electron transport materials and organic electroluminescent device comprising the same. And the patent contained the following:

Electron buffering materials and electron transport materials are described by the general formula I (X1 = -N:, -NR7-, -O- or -S-; Y1 = -N:, -NR8-, -O- or -S- with the restriction that when X1 = -N:, Y1 = -NR8-, -O-, or -S-, when X1 = -NR7-, Y1 = -N:, -O- or -S-, X1 and Y1 may not both be -O- or -S-, and one of X1 and Y1 may not be -O- when the other is -S-; R1 = (un)substituted C6-30 aryl, or (un)substituted 3-30 membered heteroaryl; R2-4, R7, and R8 = independently selected H, D, halo, cyano, (un)substituted C1-30 alkyl, (un)substituted C6-30 aryl, (un)substituted 3-30 membered heteroaryl, etc.; b = 1 or 2; c = 1 or 2; and d = 1-4). Organic electroluminescent devices employing the materials are also described. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Related Products of 1268137-13-8

The Article related to electron buffering transport heterocyclic compound organic electroluminescent device, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Spectrometers and Optical Apparatus and other aspects.Related Products of 1268137-13-8

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On March 21, 2018, Ahn, Hui Chun; Moon, Du Hyeon; Cho, Sang Hui published a patent.Computed Properties of 1268137-13-8 The title of the patent was Organic electroluminescent device comprising electron buffer layer and electron transport layer. And the patent contained the following:

The present invention relates to an organic electroluminescent device representing high efficiency and / or long life by including a specific combination of electronic buffer material and electron transport material. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Computed Properties of 1268137-13-8

The Article related to electron buffer transport organic electroluminescent device, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Spectrometers and Optical Apparatus and other aspects.Computed Properties of 1268137-13-8

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On July 15, 2015, Kim, Hyungsun; Kim, Byungku; Kim, Youngkwon; Kim, Changwoo; Shin, Changju; Lee, Seungjae; Yu, Eunsun; Choi, Byoungki; Hwang, Kyuyoung published a patent.Recommanded Product: 7-Bromo-2-phenylbenzo[d]oxazole The title of the patent was Condensed cyclic compounds and organic light-emitting devices including the same. And the patent contained the following:

The title condensed cyclic compound are I wherein L1, E1, R1, X11 to X13, X21 to X26, a1, b1 and c1 are described in the specification. An organic light-emitting device including such a compound is also disclosed. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Recommanded Product: 7-Bromo-2-phenylbenzo[d]oxazole

The Article related to condensed cyclic compound organic light emitting device, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Spectrometers and Optical Apparatus and other aspects.Recommanded Product: 7-Bromo-2-phenylbenzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On January 7, 2019, Kim, Hyeong Seon; Shin, Chang Ju; Yoo, Eun Seon; Lee, Byeong Gwan; Jung, Ho Guk; Cho, Pyeong Seok; Lee, Sang Sin; Jung, Seong Hyeon published a patent.Safety of 7-Bromo-2-phenylbenzo[d]oxazole The title of the patent was Compounds for organic optoelectronic devices and display device comprising the same. And the patent contained the following:

A compound for organic optoelectronic device and a display device comprising the same having high-efficiency is provided. The compound is represented by formula 1, wherein T is a substituted or unsubstituted C2 to C30 heterocyclic group containing at least two nitrogen, L is a single bond, a substituted or unsubstituted C6 to C30 arylene group, a substituted or unsubstituted C2-C30 heteroarylene group, or its combination, X is oxygen or sulfur, Ar is a substituted or unsubstituted C6-C12 aryl group, R1-R4 each independently represent hydrogen, deuterium, a substituted or unsubstituted C1-C20 alkyl group, a substituted or unsubstituted C2-C20 alkenylene group, a substituted or unsubstituted C6-C20 aryl group, a substituted or unsubstituted C2-C30 heterocyclic group, or its combination, at least two of R1-R4 are connected to adjacent groups to form at least one substituted or unsubstituted aromatic ring or substituted or unsubstituted heteroaromatic ring, Ra is hydrogen, deuterium, a substituted or unsubstituted C1-C4 alkyl group, or a substituted or unsubstituted C6-C12 aryl group, Means that at least one hydrogen is substituted with deuterium, a C1-C10 alkyl group, a C6-C12 aryl group, or a C2-C10 heteroaryl group. Further, the compounds for an organic optoelectronic device is selected from the compounds represented in Group 1. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Safety of 7-Bromo-2-phenylbenzo[d]oxazole

The Article related to organic optoelectronic display device, Optical, Electron, and Mass Spectroscopy and Other Related Properties: Spectrometers and Optical Apparatus and other aspects.Safety of 7-Bromo-2-phenylbenzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On November 23, 2021, Gao, Chunji; Zhao, Xiaoyu published a patent.Safety of 7-Bromo-2-phenylbenzo[d]oxazole The title of the patent was Preparation of heterocyclic compound as light emitting host material layer for organic electroluminescent device. And the patent contained the following:

The invention relates to preparation of heterocyclic compound as light emitting host material layer for organic electroluminescent device. In particular, the heterocyclic compound as light emitting host material layer I or II (wherein, Ar1 – Ar4 = (un)substituted C6-C30 aryl or (un)substituted C3-C30 heteroaryl groups; X1 – X4 = C or N; Y1 and Y2 = NR1 or O; R1 = (un)substituted C1-C20 alkyl, (un)substituted C6-30 aryl or (un)substituted C3-C30 heteroaryl group; L1 and L2 = single bond, (un)substituted C6-C30 arylene, or (un)substituted C3-C30 heteroarylene group). Further, (R2 – R9 = H, D, halogen, cyano, carboxy, nitro, hydroxyl, (un)substituted C1-C20 alkyl, (un)substituted C3-C30 cycloalkyl, (un)substituted C3-C30 cycloalkenyl group, (un)substituted C3-C7 heterocycloalkyl, (un)substituted C6-C30 aryl, (un)substituted C3-C30 heteroaryl; or adjacent ones of R2 to R9 may be connected to each other to form one or more rings, the premise is that at least one pair of R2 and R3, R3 and R4, R4 and R5, R5 and R6, R6 and R7, R7 and R8, and R8 and R9 may be connected to each other to form one or more rings, wherein the ring has 1 to 5 single rings) was prepared The organic electroluminescent device of the present invention has excellent luminous efficiency and lifetime. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Safety of 7-Bromo-2-phenylbenzo[d]oxazole

The Article related to oxazolophenanthridine derivative preparation light emitting host material oled, imidazophenanthridine derivative preparation light emitting host material oled, carbazole derivative preparation light emitting host material oled and other aspects.Safety of 7-Bromo-2-phenylbenzo[d]oxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

On November 14, 2017, Huang, Jinhai; Su, Jianhua published a patent.Computed Properties of 1268137-13-8 The title of the patent was Spirocarbazole organic electroluminescent compound, its preparation and application in organic electroluminescent device. And the patent contained the following:

The invention relates to spirocarbazole organic electroluminescent compound of formula I, its preparation and application in organic electroluminescent device. Compounds I, wherein X is N, O, S, etc.; Y is N, O, S, etc.; R1 to R9 are independently H, C1-12 alkyl, (un)substituted C6-30 aryl, etc.; A is single bond or no exist; are claimed. The organic electroluminescent device comprises an anode, a cathode and an organic layer. The organic layer comprises one or more of luminescent layer, hole injection layer, hole transport layer, hole barrier layer, electron injection layer and electron transport layer. The organic electroluminescent device has advantages of good electroluminescence efficiency, excellent color purity and long service life. The experimental process involved the reaction of 7-Bromo-2-phenylbenzo[d]oxazole(cas: 1268137-13-8).Computed Properties of 1268137-13-8

The Article related to spirocarbazole preparation application organic electroluminescent device oled, Heterocyclic Compounds (One Hetero Atom): Indoles, Indolizines, Carbazoles, and Other Arenopyrroles and other aspects.Computed Properties of 1268137-13-8

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem