Category: 136630-39-2

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 136630-39-2, Name is 2,7-Dibromo-9H-carbazole, molecular formula is C12H7Br2N. In an article, author is Mo, Lingchao,once mentioned of 136630-39-2, Quality Control of 2,7-Dibromo-9H-carbazole.

New negative dielectric anisotropy liquid crystals based on benzofuran core

In this paper, new liquid crystal compounds with negative dielectric anisotropy were synthesised by regulating the substituents on the benzofuran ring. Their structures were confirmed by(1)H-nuclear magnetic resonance,(CNMR)-C-13 and mass spectra. The effects of substituent on the properties of liquid crystals were investigated. Compared with the reference compounds, the compounds with 5-ethoxy-6,7-difluorobenzofuran ring exhibit higher clearing points as well as the tendency of expansion of SmA phase range. The density functional theory calculation results reveal that the 6-ethoxy-7-fluorobenzofuran-based compound has smaller aspect ratio than that of the 5-ethoxy-6,7-difluorobenzofuran-based compound, which results in the diminish of the mesophase. Although the dielectric anisotropy of the 5-ethoxy-6,7-difluorobenzofuran-based compound is slightly lower than that of the reference compound, it has both the largest perpendicular and parallel dielectric constant.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Let’s face it, organic chemistry can seem difficult to learn. Especially from a beginner’s point of view. Like 136630-39-2, Name is 2,7-Dibromo-9H-carbazole. In a document, author is Cheng, Ying, introducing its new discovery. COA of Formula: C12H7Br2N.

A benzoxazole compound as a novel MEK inhibitor for the treatment of RAS/RAF mutant cancer

Mutations in RAS/RAF occur in large portion of malignancies and are associated with aggressive clinical behaviors and poor prognosis. Therefore, we developed a novel benzoxazole compound (KZ-001) as a highly potent and selective MEK 1/2 inhibitor. Our efforts were focused on enhancing the activity of the known MEK inhibitor AZD6244 and overcoming the shortcomings existing in current MEK inhibitors. Here we show that compound KZ-001 exhibits approximately 30-fold greater inhibition against BRAF- and KRAS-mutant tumor cells than that of AZD6244. These results were also demonstrated using in vivo xenograft models. Furthermore, pharmacokinetics (PK) analysis was performed for KZ-001, and this compound showed good orally bioavailability (28%) and exposure (AUC(0-infinity) = 337 +/- 169 ng h/mL). To determine its potential clinical application, the synergistic effect of KZ-001 with other agents was investigated both in vitro and in vivo (xenograft models). KZ-001 exhibited synergistic anti-cancer effect in combination with BRAF inhibitor vemurafenib and a microtubule-stabilizing chemotherapeutic agent docetaxel. In addition, KZ-001 inhibited the MAPK pathway like known MEK inhibitors. In summary, KZ-001, a structurally novel benzoxazole compound, was developed as a MEK inhibitor that has potential for cancer treatment.

I hope this article can help some friends in scientific research. I am very proud of our efforts over the past few months and hope to 136630-39-2 help many people in the next few years. COA of Formula: C12H7Br2N.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 136630-39-2, Name is 2,7-Dibromo-9H-carbazole, SMILES is BrC1=CC2=C(C=C1)C3=C(C=C(Br)C=C3)N2, belongs to benzoxazole compound. In a document, author is Yuan, Xinglong, introduce the new discover, Product Details of 136630-39-2.

Elemental Sulfur Participates in the Decarboxylative Coupling of Oxidized 2-Aminophenol and Phenylglyoxylic Acid

A simple and practical elemental sulfur-catalyzed one-pot method for the synthesis of benzoxazole derivatives has been developed. The protocol uses inexpensive elemental sulfur as the catalyst and highly effective to promote this transformation without the aid of any metal salts. The corresponding benzoxazoles were achieved in good to high yields. Compared with previous methods, becouse of elemental sulfur promoted decarboxylative cyclization was unique and allow highly flexible and wide range of applications displays great potential for replacing existing methodologies.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 136630-39-2 is helpful to your research. Product Details of 136630-39-2.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

In an article, author is Kakkar, Saloni, once mentioned the application of 136630-39-2, Name: 2,7-Dibromo-9H-carbazole, Name is 2,7-Dibromo-9H-carbazole, molecular formula is C12H7Br2N, molecular weight is 325, MDL number is MFCD09033507, category is benzoxazole. Now introduce a scientific discovery about this category.

Design, synthesis and biological potential of heterocyclic benzoxazole scaffolds as promising antimicrobial and anticancer agents

Background: Benzoxazole is the most important class of heterocyclic compound in medicinal chemistry. It has been incorporated in many medicinal compounds making it a versatile heterocyclic compound that possess a wide spectrum of biological activities. Results: The molecular structures of synthesized benzoxazole derivatives were confirmed by physicochemical and spectral means. The synthesized compounds were further evaluated for their in vitro biological potentials i.e. antimicrobial activity against selected microbial species using tube dilution method and antiproliferative activity against human colorectal carcinoma (HCT 116) cancer cell line by Sulforhodamine B assay. Conclusion: In vitro antimicrobial results demonstrated that compounds 4, 5, 7 and 16 showed promising antimicrobial potential. The in vitro anticancer activity indicated that compounds 4 and 16 showed promising anticancer activity against human colorectal cancer cell line (HCT 116) when compared to standard drug and these compounds may serve as lead compound for further development of novel antimicrobial and anticancer agents.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 136630-39-2, Name is 2,7-Dibromo-9H-carbazole, SMILES is BrC1=CC2=C(C=C1)C3=C(C=C(Br)C=C3)N2, belongs to benzoxazole compound. In a document, author is Wu, Huilu, introduce the new discover, Formula: C12H7Br2N.

Synthesis, structure, luminescence and electrochemical and antioxidant properties of anion-controlled silver(I) complexes with 2,2 ‘-(1,4-butanediyl)bis-1,3-benzoxazole

To explore the influence of various anions on the self-assembly and properties of silver complexes, reactions of anions of silver salts with 2,2 ‘-(1,4-butanediyl)bis-1,3-benzoxazole (BBO) afforded four complexes, formulated as [Ag-2(BBO)(2)(p-toluenesulfonate)(2)] (1), {[Ag(BBO)(picrate)]}(infinity) (2), {[Ag(BBO)(1/2)(o-coumarate)]center dot DMF}(infinity) (3) and {[Ag-2(BBO)(3)](PF6)(2)}(infinity) (4). These complexes were characterized using elemental analysis, infrared spectroscopy and single-crystal X-ray diffraction. The crystal analysis results show that under the influence of coordination modes and steric hindrance of anions, the complexes exhibited binuclear (1), one-dimensional polymeric (2 and 3) and two-dimensional polymeric (4) structures. Compared with the BBO ligand, only complex 1 has a new emission peak at 428 nm, which is attributed to ligand-metal charge transfer. The emission peaks of complexes 2-4 are similar to those of the BBO ligand, which can be due to pi-pi* and n-pi* transitions. These results indicate that anions can modulate the structures and luminescent properties of silver complexes. Moreover, cyclic voltammograms of 1-4 indicated an irreversible Ag+/Ag couple with the order of reversibility being 2 > 1 > 4 > 3. In vitro antioxidant experiments showed that complex 3 has significant antioxidant activity against superoxide and hydroxyl radicals.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 136630-39-2 is helpful to your research. Formula: C12H7Br2N.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, such as the rate of change in the concentration of reactants or products with time. 136630-39-2, Name is 2,7-Dibromo-9H-carbazole, formurla is C12H7Br2N. In a document, author is Zhao, Jinyu, introducing its new discovery. Quality Control of 2,7-Dibromo-9H-carbazole.

Mechanofluorochromism of difluoroboron beta-ketoiminate boron complexes functionalized with benzoxazole and benzothiazole

New difluoroboron beta-ketoiminate boron complexes bearing benzoxazole (CBO) and benzothiazole (CBS) have been synthesized. It was found that CBO was almost non-emissive in THF, and the emission could be intensified significantly when great amount of H2O was added, illustrating AIE (aggregation-induced emission) property. CBS could not show AIE property in THF/H2O system, but its emission in solid state was also strong. The single crystal structure of CBS suggested that pi-pi interactions and the hydrogen bonds of C(Ar) – F center dot center dot center dot H, C(Ar) – H center dot center dot center dot S and C(Ar) – H center dot center dot center dot Cl would suppress the rotation of single bonds, resulting into obvious emission enhancement. It is interesting that the as-synthesized crystals of CBO and CBS both emitted azure light, and the grinding made their emitting colors to change into cyan and green, which could be recovered under fuming with DCM or heating. The reversible mechanofluorochromism was due to the transformation between crystalline and amorphous states, which could be confirmed from the results of absorption spectra, XRD patterns and DSC curves in different solid states. Additionally, the high-contrast mechanofluorochromism of CBS compared with CBO might be originated from the loose packing in crystalline state and the better pi-electron delocalization.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

136630-39-2, Name is 2,7-Dibromo-9H-carbazole, molecular formula is C12H7Br2N, belongs to benzoxazole compound, is a common compound. In a patnet, author is Balalas, T. D., once mentioned the new application about 136630-39-2, Computed Properties of C12H7Br2N.

One-pot Synthesis of 2-Substituted 4H-Chromeno[3,4-d]oxazol-4-ones from 4-Hydroxy-3-nitrocoumarin and Acids in the Presence of Triphenylphosphine and Phosphorus Pentoxide under Microwave Irradiation

2-Substituted 4H-chromeno[3,4-d]oxazol-4-ones are prepared from 4-hydroxy-3-nitrocoumarin and acids by one-pot reaction in the presence of PPh3 and P2O5 under microwave irradiation or by onepot two-step reactions in the presence of Pd/C and hydrogen and then P2O5 under microwave irradiation. The fused oxazolocoumarins were also synthesized from 3-amido-4-hydroxycoumarins and P2O5 under microwave irradiation. The 3-amido-4-hydroxycoumarins are obtained almost quantitatively from 4-hydroxy-3-nitrocoumarin, acids and PPh3 under microwave irradiation, or in the presence of Pd/C and H-2 on heating. Preliminary biological tests indicate significant inhibition of soybean lipoxygenase and antilipid peroxidation for both oxazolocoumarins and o-hydroxyamidocoumarins.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, 136630-39-2. The above is the message from the blog manager. Computed Properties of C12H7Br2N.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Chemistry is the experimental and theoretical study of materials on their properties at both the macroscopic and microscopic levels. 136630-39-2, Name is 2,7-Dibromo-9H-carbazole, molecular formula is C12H7Br2N. In an article, author is Luo, Bo,once mentioned of 136630-39-2, COA of Formula: C12H7Br2N.

Synthesis, Antifungal Activities and Molecular Docking Studies of Benzoxazole and Benzothiazole Derivatives

Based on benzoxazole and benzothiazole scaffold as an important pharmacophore, two series of 2-(aryloxymethyl) benzoxazole and benzothiazole derivatives were synthesized and their antifungal effects against eight phytopathogenic fungi were evaluated. Compounds 5a, 5b, 5h, and 5i exhibited significant antifungal activities against most of the pathogens tested. Especially 5a, 5b, 5h, 5i, 5j, and 6h inhibited the growth of F. solani with IC50 of 4.34-17.61 mu g/mL, which were stronger than that of the positive control, hymexazol (IC50 of 38.92 mu g/mL). 5h was the most potent inhibitor (IC50 of 4.34 mu/mL) against F. Solani, which was about nine times more potent than hymexazol. Most of the test compounds displayed significant antifungal effects against B. cinerea (IC50 of 19.92-77.41 mu g/mL), among them, 5a was the best one (IC50 of 19.92 mu g/mL). The structure-activity relationships (SARs) were compared and analyzed. The result indicates that the electron-drawing ability and position of the substituents have a significant impact on biological activities. Furthermore, docking studies were carried out on the lipid transfer protein sec14p from S. cerevisiae, and preliminarily verified the antifungal activities. Taken together, these results provide 2-(phenoxymethyl)benzo[d]oxazole as an encouraging framework that could lead to the development of potent novel antifungal agents.

Interested yet? Keep reading other articles of 136630-39-2, you can contact me at any time and look forward to more communication. COA of Formula: C12H7Br2N.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature. Recommanded Product: 136630-39-2, 136630-39-2, Name is 2,7-Dibromo-9H-carbazole, SMILES is BrC1=CC2=C(C=C1)C3=C(C=C(Br)C=C3)N2, in an article , author is Gan, Feng, once mentioned of 136630-39-2.

Preparation of thermally rearranged poly(benzoxazole-co-imide) membranes containing heteroaromatic moieties for CO2/CH4 separation

Simultaneously achieving excellent mechanical properties and superior gas separation performance remains a great challenge for thermally rearranged polymers when applied as the membrane materials in large scale gas separation applications. Herein, different heteroaromatic non-TR-able codiamines containing benzimidazole/benzoxazole structures were incorporated into ortho-hydroxyl functionalized polyimide backbones, which were subsequently transformed into the poly(benzoxazole-co-polyimide) copolymers by thermal rearrangement (TR). In all cases, the solid-state TR reaction induces the increased preferential intersegmental distances (d-spacing) and fractional free volumes of polymer chains, favorable for the gas permeation. While, the pi-pi stacking distance exhibits opposite variation tendencies for benzimidazole-based and benzoxazole-based TR-PBOI membranes, which is demonstrated to make a significant effect on the gas selectivity. These TR-PBOI membranes thermally treated at 420 degrees C for 1 h exhibit higher tensile properties in relative to most of previously reported TR-PBOI membranes with the tensile strength of 97-118 MPa and initial modulus of 2.0-2.4 GPa. Moreover, incorporating heteroaromatic non-TR-able codiamines endows the resultant TR-PBOI membranes with excellent gas separation properties for the CO2/CH4 gas pairs with the CO2 permeability and CO2/CH4 ideal selectivity values exceeding the 1991 upper bound and close to 2008 upper bound. We anticipate this facile method will facilitate the large-scale preparation and application of TR membranes for gas separation.

But sometimes, even after several years of basic chemistry education, it is not easy to form a clear picture on how they govern reactivity! 136630-39-2, you can contact me at any time and look forward to more communication. Recommanded Product: 136630-39-2.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Chemistry is an experimental science, and the best way to enjoy it and learn about it is performing experiments.Introducing a new discovery about 136630-39-2, Name is 2,7-Dibromo-9H-carbazole, molecular formula is , belongs to benzoxazole compound. In a document, author is Babu, Kayathi Narendra, Quality Control of 2,7-Dibromo-9H-carbazole.

Synthesis and Antimicrobial Activity of Bis(azolyl) Urea Derivatives

A variety of bis(azolyl) urea derivatives were prepared by the reaction of methyl benzazoyl carbamates with azolyl amines in the presence of mild base and studied their antimicrobial activity. The presence of electron donating substituents on the aromatic ring enhanced the activity. Methoxy substituted benzothiazolyl thiazolyl urea, benzothiazolyl imidazolyl urea and benzimidazolyl thiazolyl urea displayed prominent antibacterial activity against Bacillus subtilis. Benzothiazolyl imidazolyl urea and methyl substituted benzimidazolyl imidazolyl urea showed good antifungal activity against Aspergillus niger.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem