Category: 13673-62-6

13673-62-6, 2-(Methylthio)benzo[d]oxazole is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

13673-62-6, In order to prepare intermediate c-3, chlorosulfonic acid (3890 g; 33.3 mol) was stirred under nitrogen. Then intermediate c-2 (1288 g; 7.80 mol) was added portionwise maintaining the internal temperature below 60C by external cooling. After complete addition of intermediate b-2 the reaction mixture was stirred overnight at 85C. The heating was removed and the reaction mixture was cooled down until 65C. SOC12 was added dropwise while maintaining a controlled release of gases by good stirring. This mixture was stirred overnight at 65C. This reaction mixture was added to a well stirred mixture of EtOAc (6.9 kg) and ice (9.2kg) while maintained the temperature below 0C. The organic layer was isolated. The aqueous phase was extracted with EtOAc (3.1 KG). The combined organic layer was washed with 7.5 % NAHC03 (210 g/2.8 L water). Because the pH of this water layer was still 1, therefore another 125 g NAHC03 was added. This mixture was stirred for 1 hour, then the phases were separated. The organic layer was dried with NA2C03 (2.5 kg). After filtration 1935 g of intermediate c-3 was obtained (yield 94%, HPLC purity 94%) and used in the preparation of compound c-6.

The synthetic route of 13673-62-6 has been constantly updated, and we look forward to future research findings.

Reference£º
Patent; TIBOTEC PHARMACEUTICALS LTD.; WO2005/30739; (2005); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

13673-62-6, 2-(Methylthio)benzo[d]oxazole is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 6 N-(2-benzoxazolyl)-O-[4-oxo-4-[(1,4,5,6-tetrahydro-2-pyrimidinyl)amino]butyl]-L-tyrosine (1,1-dimethyl ethyl) N-(2-benzoxazolyl)-O-(4-ethoxy-4-oxobutyl)-L-tyrosinate (6-1) A mixture constituted by aminoester 5-3 (1.05 g, 3 mmole), 2-methylthiobenzoxazole (660 mg, 4 mmoles) and HgCl2 (50 mg) is heated at 140 C. for 4 hours. The mixture obtained after cooling down is purified by chromatography eluding with a heptane/AcOEt mixture 50/50. 370 mg of the expected product 6-1 is obtained. IR (CHCl3) NH 3413 cm-1; C=O 1729 cm-1; Heterocycle+Aromatic 1642, 1612, 1582, 1512 cm-1, 13673-62-6

13673-62-6 2-(Methylthio)benzo[d]oxazole 4178773, abenzoxazole compound, is more and more widely used in various fields.

Reference£º
Patent; Demassey, Jacques; Gourvest, Jean-Francois; Ruxer, Jean-Marie; Weston, John Bernard; LeFrancois, Jean-Michel; US2004/225111; (2004); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.13673-62-6,2-(Methylthio)benzo[d]oxazole,as a common compound, the synthetic route is as follows.

Ethyl N-(2-benzoxazolyl)-O-[3-(5,6,7,8-tetrahydro-1,8-naphthyridin-2-yl)propyl]-L-tyrosinate (3-1) A mixture constituted by 1-4 (120 mg, 0.3 mmole) and 2-methylthiobenzoxazole (0.5 ml) and 30 mg of mercury dichloride is heated at 140 C. for 3 hours, followed by evaporating under reduced pressure and purifying by chromatography eluding with a gradient of AcOEt (0—>100) in CH2Cl2 in order to obtain 55 mg of the expected 3-1. IR (CHCl3) NH 3424 cm-1 (Max); C=O 1735 cm-1; conjugated system+Aromatic 1644, 1599, 1583, 1512 cm-1., 13673-62-6

As the paragraph descriping shows that 13673-62-6 is playing an increasingly important role.

Reference£º
Patent; Demassey, Jacques; Gourvest, Jean-Francois; Ruxer, Jean-Marie; Weston, John Bernard; LeFrancois, Jean-Michel; US2004/225111; (2004); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem