Grandhi, Gowri Sankar’s team published research in Organic Letters in 2020-04-03 | CAS: 145026-07-9

Copper-Catalyzed 8-Aminoquinoline-Directed Oxidative C-H/N-H Coupling for N-Arylation of Sulfoximines. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.

A copper-catalyzed cross-dehydrogenative C-H/N-H coupling has been devised to access a series of N-arylated sulfoximines, e,g., I, in high yield from 8-aminoquinoline-derived benzamides and sulfoximines. The reaction is scalable, and mechanistic studies favor the involvement of an organometallic pathway, where C-H bond cleavage is presumed to be the kinetically relevant step. The utility of sulfoximine-coupled benzamides was displayed through the nickel-catalyzed acceptorless dehydrogenative olefination of benzyl alcs.

Copper-Catalyzed 8-Aminoquinoline-Directed Oxidative C-H/N-H Coupling for N-Arylation of Sulfoximines. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Cheng, Ying’s team published research in Angewandte Chemie, International Edition in 2015 | CAS: 145026-07-9

Regioselective Syntheses of 1,2-Benzothiazines by Rhodium-Catalyzed Annulation Reactions. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.

Rhodium-catalyzed directed carbene insertions into aromatic C-H bonds of S-aryl sulfoximines led to intermediates, which upon dehydration provided 1,2-benzothiazines, e.g., I, in excellent yields. The domino-type process is regioselective and shows a high functional-group tolerance. It is scalable, and the only byproducts are dinitrogen and water.

Regioselective Syntheses of 1,2-Benzothiazines by Rhodium-Catalyzed Annulation Reactions. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Zou, Ya’s team published research in European Journal of Organic Chemistry in 2015 | CAS: 145026-07-9

CuI-Mediated ¦Á-Ketoacylation of Sulfoximines under Solvent-Free Conditions. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.

A series of desired 2-oxo-2-arylacetyl sulfoximines RC(O)C(O)N=S(O)R1R2 [R = C(CH3)3, 3,4-Cl2C6H3, thiophen-2-yl, naphth-2-yl, etc.; R1 = Me, Et, i-Pr, Ph; R2 = C6H5, 2-ClC6H4, 4-H3COC6H4, etc.; R1R2 = -(CH2)4-] were successfully synthesized in good to excellent yields (up to 93%) under solvent-free conditions using aryl ethanones RC(O)CH3 and NH-sulfoximines R1R2S(O)=NH. The unprecedented protocol requires no extra solvents, bases, or additives and demonstrates outstanding compatibility with assorted functional groups (up to 27 examples). A plausible double catalytic cycle mechanism involving elemental iodine and copper is proposed; in-situ generated aryl-¦Á-iodo-ethanone and a sulfoximine-liganded-CuII intermediate play important roles in C(sp3)-N coupling. The postulated mechanism is inspired by key exptl. investigations detailed here.

CuI-Mediated ¦Á-Ketoacylation of Sulfoximines under Solvent-Free Conditions. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Baranwal, Siddharth’s team published research in Tetrahedron Letters in 2020-07-02 | CAS: 145026-07-9

Copper catalyzed N-arylation of sulfoximines with aryldiazonium salts in the presence of DABCO under mild conditions. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

1-Bromo-4-(S-methylsulfonimidoyl)benzene (BD336512) is a building block containing a sulfoximine group. Several CDK and ATR inhibitors have exemplified the utilization of the NH sulfoximine group as abioisostere for a sulfonamide group to overcome the main project hurdles of aqueous solubility, sulfonamide-mediated off-target activity and IP. Moreover, its NH group could be expediently further functionalized through Buchwald-Hartwig coupling reaction and multifarious nucleophilic reactions.. Recommended Products is: 4381-25-3 and 83730-53-4.

N-Arylation of sulfoximines with aryldiazonium tetrafluoroborates was demonstrated in the presence of copper chloride and DABCO. A wide range of aryl and alkyl sufoximines were participated in the coupling reaction with different aryldiazonim salts bearing electron donating and withdrawing groups and provided the desired products in 67-88% yields. The reaction proceeded through a radical mechanism.

Copper catalyzed N-arylation of sulfoximines with aryldiazonium salts in the presence of DABCO under mild conditions. Recommended basis is Sulfoximine, Bioisosteric. Products is: https://www.ambeed.com/products/1621962-30-8.html, 50578-18-2

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem