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TRANS-3-AZA-BICYCLO[3.1.0]HEXANE DERIVATIVES

The invention relates to novel trans-3-aza-bicyclo[3.1.0]hexane derivatives of formula (I), wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

New explortion of Benzo[d]oxazole-4-carboxylic acid

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Reference of 208772-23-0, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.208772-23-0, Name is Benzo[d]oxazole-4-carboxylic acid, molecular formula is C8H5NO3. In a article£¬once mentioned of 208772-23-0

Efficacious inhaled PDE4 inhibitors with low emetic potential and long duration of action for the treatment of COPD

Oral phosphodiesterase 4 (PDE4) inhibitors, such as cilomilast and roflumilast, have been shown to be efficacious against chronic obstructive pulmonary disease (COPD). However, these drugs have been hampered by mechanism-related side effects such as nausea and emesis at high doses. Compounds administered by inhalation are delivered directly to the site of action and may improve the therapeutic index required to overcome side effects. This paper describes systematic and rational lead optimization to deliver highly potent, long-acting, and efficacious preclinical inhaled PDE4 inhibitors with low emetic potential.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

More research is needed about Benzo[d]oxazole-4-carboxylic acid

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2-ALKYLBENZOXAZOLE CARBOXAMIDES AS 5HT3 MODULATORS

Compounds of formulae I and II: [image] are disclosed as 5-HT3 inhibitors. Those compounds are useful in treating CINV, IBS-D and other diseases and conditions.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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Benzamide derivatives having a vasopressin antagonistic activity

This invention relates to new benzamide derivatives having a vasopressin antagonistic activity, etc. and represented by general formula (I): wherein R1 is aryl optionally substituted with lower alkoxy, etc.,R2 is lower alkyl, etc.,R3 is hydrogen, etc.,A is NH, etc.,E is etc.,X is ?CH=CH?, ?CH=N?, or S, andY is a condensed heterocyclic group, etc.,and pharmaceutically acceptable salts thereof, to processes for preparation thereof and to a pharmaceutical composition comprising the same.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. name: Benzo[d]oxazole-4-carboxylic acid, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 208772-23-0, in my other articles.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Brief introduction of Benzo[d]oxazole-4-carboxylic acid

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Benzimidazole compounds

Benzimidazole-4-carboxamide compounds (I) which can act as potent inhibitors of the DNA repair enzyme poly(ADP-ribose) polymerase or PARP enzyme (EC 2.4.2.30), and which thereby can provide useful therapeutic compounds for use in conjunction with DNA-damaging cytotoxic drugs or radiotherapy to potentiate the effects of the latter. In formula (I), R and R” may each be selected independently from hydrogen, alkyl, hydroxyalkyl (e.g. CH2CH2OH), acyl (e.g. acetyl or benzoyl) or an optionally substituted aryl (e.g. phenyl) or aralkyl (e.g. benzyl or carboxybenzyl) group. R is generally a substituted phenyl group in the most preferred compounds. The compounds may also be used in the form of pharmaceutically acceptable salts or pro-drugs.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In a patent, 208772-23-0, molecular formula is C8H5NO3, introducing its new discovery. 208772-23-0

2-AZA-BICYCL0[3.1.0]HEXANE DERIVATIVES

The invention relates to novel 2-aza-bicyclo[3.1.0]hexane derivatives of Formula (I) wherein A, B, n and R1 are as described in the description, and to the use of such compounds, or of pharmaceutically acceptable salts of such compounds, as medicaments, especially as orexin receptor antagonists.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem