Category: 22876-22-8

Electric Literature of 22876-22-8, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 22876-22-8, Name is 5-Methylbenzo[d]oxazole-2(3H)-thione, molecular formula is C8H7NOS. In a Article£¬once mentioned of 22876-22-8

Synthesis and characterization of oxazolopyridine and benzoxazole derivatives

Synthesis of piperazinyl-substituted oxazolopyridine and benzoxazole was achieved in three steps starting from aminophenol and carbon disulfide. Condensation of aminophenols with carbon disulfide in ethanol using potassium hydroxide as catalyst gave the required benzoxazole thiol in one step. Treatment of the thiol with piperazine and substituted piperazine derivatives in toluene furnished the titled compounds in good yield. We introduced halogen substitution in the pendant arm of the piperazine derivatives for versatile functionalization. We report the synthesis and characterization of these compounds using high resolution NMR techniques.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Electric Literature of 22876-22-8. In my other articles, you can also check out more blogs about 22876-22-8

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Catalysts are substances that increase the reaction rate of a chemical reaction without being consumed in the process. 22876-22-8, Name is 5-Methylbenzo[d]oxazole-2(3H)-thione, molecular formula is C8H7NOS, 22876-22-8, In a Article, authors is Ocura, Haruo£¬once mentioned of 22876-22-8

STUDIES ON HETEROCYCLIC COMPOUNDS. XXXIV. SYNTHESIS OF 2-SUBSTITUTED AMINOBENZOXAZOLES WITH NICKEL PEROXIDE

Oxidation of N-methyl (or phenyl)-N’-(4-methylpyrid-2-yl)thiourea (Ia, b) with nickel peroxide (Ni-PO) under reflux in benzene or acetonitrile afforded the corresponding ureas (IIa, b).N-(2-Hydroxy-5-methylphenyl)-N’-methylthiourea (IVa) was synthesized by the reaction of 2-amino-4-methylphenol (III) and methyl isothiocyanate in benzene under reflux.Howevwer, the reaction of III and phenyl isothiocyanate in benzene under reflux did not afford the thiourea (IVb) but IVb was obtained in ethanol at room temperature.NiPO oxidation of thioureas (IVa-f) in acetonitrile at room temperature afforded 2-substituted aminobenzoxazoles (VIIa-f) in good yields.The reaction mechanisms of Ni-PO and thioureas (Ia, b and IVa-f) are discussed.Keywords: – N-substituted N’-(4-methylpyrid-2-yl)thioureas; N-substituted N’-(4-methylpyrid-2-yl)ureas; N-(2-hydroxyphenyl) N’-substituted thioureas; 2-substituted aminobenzoxazoles; nickel peroxide; oxidative cyclization; 2-mercaptobenzoxazole; isothiocyanates

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.22876-22-8. In my other articles, you can also check out more blogs about 22876-22-8

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

22876-22-8, In heterogeneous catalysis, the catalyst is in a different phase from the reactants. At least one of the reactants interacts with the solid surface in a physical process called adsorption in such a way. 22876-22-8, name is 5-Methylbenzo[d]oxazole-2(3H)-thione. In an article£¬Which mentioned a new discovery about 22876-22-8

A new 5-HT3 receptor ligand. II. Structure-activity analysis of 5-HT3 receptor agonist action in the gut

Several modified 2-piperazinyl benzoxazole derivatives, which exhibit an agonistic effect on gastrointestinal motility, were synthesized and their effects on the contraction of guinea-pig ileum were examined. The quaternary piperazinyl benzoxazole structure has a restricted conformation and stereostructure compared to those of the other 5-HT3 receptor agonists, serotonin and meta-chlorophenylbiguanide. The mutual positions of the aromatic ring, nitrogen atom and terminal amine are considered to form the pharmacophore of the 5-HT3 receptor agonist in the gut. In the serotonin- evoked reflex bradycardia [Bezold-Jarisch (B-J) reflex] inhibition test using rats the B-J reflex-inducing ratio was different for each synthesized compound. These results suggest that, in these 5-HT3 receptor agonists, the substituents of the benzoxazole ring influence the B-J reflex-inducing activity in rats.

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 22876-22-8 is helpful to your research. 22876-22-8

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

22876-22-8, An article , which mentions 22876-22-8, molecular formula is C8H7NOS. The compound – 5-Methylbenzo[d]oxazole-2(3H)-thione played an important role in people’s production and life.

The first low muM SecA inhibitors

SecA ATPase is a critical member of the Sec family, which is important in the translocation of membrane and secreted polypeptides/proteins in bacteria. Small molecule inhibitors can be very useful research tools as well as leads for future antimicrobial agent development. Based on previous virtual screening work, we optimized the structures of two hit compounds and obtained SecA ATPase inhibitors with IC50 in the single digit micromolar range. These represent the first low micromolar synthetic inhibitors of bacterial SecA and will be very useful for mechanistic studies.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

As a common heterocyclic compound, it belongs to benzoxazole compound, name is 5-Methylbenzo[d]oxazole-2(3H)-thione, and cas is 22876-22-8, its synthesis route is as follows.,22876-22-8

INVENTIVE EXAMPLE 35 5-Methyl-2-(4-methyl-1-homopiperazinyl)benzoxazole 5-Methyl-2-mercaptobenzoxazole (200 mg) was dissolved in chloroform (20 ml), N-methylhomopiperazine (1.24 ml) was added dropwise to the solution and then the mixture was stirred with heating for 2 days. After evaporation of the solvent, the thus obtained mixture was purified by a silica gel column chromatography (methylene chloride_methanol=10:1) to obtain the title compound 5-methyl-2-(4-methyl-1-homopiperazinyl)benzoxazole (124 mg).

With the complex challenges of chemical substances, we look forward to future research findings about 22876-22-8,belong benzoxazole compound

Reference£º
Patent; Meiji Seika Kaisha, Ltd; Koichi Shudo; US6037342; (2000); A;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.22876-22-8,5-Methylbenzo[d]oxazole-2(3H)-thione,as a common compound, the synthetic route is as follows.

INVENTIVE EXAMPLE 9 5-Methyl-2-(1-piperazinyl)benzoxazole A 100 mg portion of 5-methyl-2-mercaptobenzoxazole was suspended in 20 ml of anhydrous toluene, and the suspension was mixed with 150 mg of phosphorus pentachloride and heated under reflux for 1 hour. The reaction solution was cooled in an ice bath and, with stirring, 500 mg of piperazine was added thereto. After 30 minutes of stirring, the ice bath was removed to carry out 1 hour of stirring at room temperature, the reaction solution was mixed with saturated sodium bicarbonate aqueous solution, and then the water layer was washed with ethyl acetate and concentrated under a reduced pressure. Thereafter, the thus obtained mixture was purified by an LH-20 gel column chromatography (chloroform:methanol=1:1) to obtain the title compound (40 mg) in white color. 1 H-NMR (DCl) delta values: 2.39 (3 H, s), 3.35 (4 H, t), 4.05 (4 H, t), 3.75 (2 H, d), 7.12 (1 H, d), 7.24 (1 H, s), 7.39 (1 H, s); MS (EI): m/z 217 (M+)

22876-22-8, 22876-22-8 5-Methylbenzo[d]oxazole-2(3H)-thione 710258, abenzoxazole compound, is more and more widely used in various fields.

Reference£º
Patent; Meiji Seika Kaisha, Ltd; Koichi Shudo; US6037342; (2000); A;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

22876-22-8, 5-Methylbenzo[d]oxazole-2(3H)-thione is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

INVENTIVE EXAMPLE 35 5-Methyl-2-(4-methyl-1-homopiperazinyl)benzoxazole 5-Methyl-2-mercaptobenzoxazole (200 mg) was dissolved in chloroform (20 ml), N-methylhomopiperazine (1.24 ml) was added dropwise to the solution and then the mixture was stirred with heating for 2 days. After evaporation of the solvent, the thus obtained mixture was purified by a silica gel column chromatography (methylene chloride_methanol=10:1) to obtain the title compound 5-methyl-2-(4-methyl-1-homopiperazinyl)benzoxazole (124 mg)., 22876-22-8

22876-22-8 5-Methylbenzo[d]oxazole-2(3H)-thione 710258, abenzoxazole compound, is more and more widely used in various fields.

Reference£º
Patent; Meiji Seika Kaisha, Ltd; Koichi Shudo; US6037342; (2000); A;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem