Category: 27231-36-3

In general, if the atoms that make up the ring contain heteroatoms, such rings become heterocycles, and organic compounds containing heterocycles are called heterocyclic compounds. An article called An environmentally benign procedure for the synthesis of substituted 2-thiobenzothiazoles, 2-thiobenzoxazoles, 2-thiobenzimidazoles, and 1,3-oxazolopyridine-2-thiols, published in 2011-09-30, which mentions a compound: 27231-36-3, Name is 2-Mercapto-5-methylbenzimidazole, Molecular C8H8N2S, SDS of cas: 27231-36-3.

An improved environmentally benign procedure for the synthesis of substituted 2-thiobenzothiaoxazoles, 2-thiobenzimidazoles, and 1,3-oxazolopyridine-2-thiols, e.g., I, by cyclization of 2-aminophenols, 2-aminothiophenols, 1,2-phenylenediamines, or 2-amino-3-hydroxypyridines with potassium O-ethyldithiocarbonate in PEG 400 or glycerol under directed microwave irradiation is described. The method can be applied to the synthesis of a variety of derivatives

《An environmentally benign procedure for the synthesis of substituted 2-thiobenzothiazoles, 2-thiobenzoxazoles, 2-thiobenzimidazoles, and 1,3-oxazolopyridine-2-thiols》 provides a strategy for the preparation of materials with excellent comprehensive properties, which is conducive to broaden the application field of this compound(2-Mercapto-5-methylbenzimidazole)SDS of cas: 27231-36-3.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Electric Literature of C8H8N2S. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Mercapto-5-methylbenzimidazole, is researched, Molecular C8H8N2S, CAS is 27231-36-3, about Synthesis of benzimidazo[2,1-b]benzothiazole derivatives through sequential Cu-catalyzed domino coupling and Pd-catalyzed Suzuki reaction. Author is Gao, Jilong; Zhu, Jiaoyan; Chen, Lubin; Shao, Yingying; Zhu, Jiaqi; Huang, Yijia; Wang, Xiaoxia; Lv, Xin.

A variety of benzo[d]benzo[4,5]imidazo[2,1-b]thiazoles were efficiently and conveniently synthesized from the Cu-catalyzed domino coupling of ortho-dihalo arenes with 2-mercaptobenzimidazoles. The reaction is also applicable to a series of multifunctional substrates, affording the halo-containing products with excellent selectivity. The brominated products can further react with arylboronic acids under Pd catalysis to furnish the arylated benzimidazo[2,1-b]benzothiazole derivatives

Different reactions of this compound(2-Mercapto-5-methylbenzimidazole)Electric Literature of C8H8N2S require different conditions, so the reaction conditions are very important.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Mercapto-5-methylbenzimidazole, is researched, Molecular C8H8N2S, CAS is 27231-36-3, about Reaction of 3-iodo-4H-1-benzopyran-4-one with 2-mercaptobenzimidazoles, the main research direction is iodobenzopyranone condensation mercaptobenzimidazole; iodochromone condensation mercaptobenzimidazole.COA of Formula: C8H8N2S.

Refluxing 3-iodo-4H-1-benzopyran-4-one with 2-mercaptobenzimodazole in DMF in the presence of Bu4NCl for 2 h gave 68% 3-(2-benzimidazolylthio)-4H-1-benzopyran-4-one. Also prepared were 3-(5-methyl-2-benzimidazolylthio)-4H-1-benzopyran-4-one and 3-(2-imidazolylthio)-4H-1-benzopyran-4-one.

Different reactions of this compound(2-Mercapto-5-methylbenzimidazole)COA of Formula: C8H8N2S require different conditions, so the reaction conditions are very important.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Epoxy compounds usually have stronger nucleophilic ability, because the alkyl group on the oxygen atom makes the bond angle smaller, which makes the lone pair of electrons react more dissimilarly with the electron-deficient system. Compound: 2-Mercapto-5-methylbenzimidazole, is researched, Molecular C8H8N2S, CAS is 27231-36-3, about Benzimidazole-2-thione and benzoxazole-2-thione derivatives as corrosion inhibitors for aluminum in hydrochloric acid.Quality Control of 2-Mercapto-5-methylbenzimidazole.

The effect of benzimidazole-2-thione and benzoxazole-2-thione derivatives on the corrosion of aluminum in 0.1 M HCl has been investigated by using a potentiostatic polarization technique. Inhibition efficiencies followed the order benzimidazole-2-thione > 5-Me benzimidazole-2-thione > 5-chloro benzimidazole-2-thione, while that of benzoxazole-2-thione derivatives followed the order 5-methylbenzoxazole-2-thione > benzoxazole-2-thione > 5-chlorobenzoxazole-2-thione > 5-nitrobenzoxazole-2-thione. The inhibitor action of these heterocyclic compounds was mainly due to adsorption on the metal surfaces, which show parallelism with the calculated total neg. charge of each of the mols. Thermodn. parameters, such as free energy of adsorption and equilibrium constant were determined Activation energy, activation enthalpy and activation entropy were determined from the corrosion currents measured at different temperatures

Different reactions of this compound(2-Mercapto-5-methylbenzimidazole)Quality Control of 2-Mercapto-5-methylbenzimidazole require different conditions, so the reaction conditions are very important.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Analytica Chimica Acta called Polarographic study of an alkyl benzimidazolyl sulfoxide and the corresponding sulfide and sulfone, Author is Johansson, Bo Lennart; Persson, Bjorn, which mentions a compound: 27231-36-3, SMILESS is SC1=NC2=CC(C)=CC=C2N1, Molecular C8H8N2S, Synthetic Route of C8H8N2S.

2-(5-Methylbenzimidazolyl)-1-(2-pyridyl)ethyl sulfide (I), II [69417-07-8], and III [69417-08-9] were reduced at a dropping Hg electrode in aqueous EtOH. Coulometric experiments at a Hg pool prove that 2-ethylpyridine [100-71-0] and 2-mercapto-5-methylbenzimidazole [27231-36-3] were formed in the reduction process of the sulfide and the sulfoxide. Coulometric reduction of the sulfone results in some conversion of the pyridine 1-oxide group together with a reductive fission of the ethyl-sulfonyl bond. One of these fission products undergoes secondary reactions. The concentration of 2-benzimidazolyl 2-pyridylmethyl sulfoxide (IV) [57237-97-5] in a pharmaceutical formulation was determined by differential pulse polarog.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Journal of Chemical and Pharmaceutical Research called Solvent extraction of palladium(II) with 2-hexyl-5-methyl benziminazole sulfide, Author is Liu, Yan; Huang, Zhangjie; Chen, Muhan; Chen, Lei, which mentions a compound: 27231-36-3, SMILESS is SC1=NC2=CC(C)=CC=C2N1, Molecular C8H8N2S, Related Products of 27231-36-3.

A new extractant of 2-hexyl-5-Me benziminazole sulfide (HMBMS) was synthesized and used in the extraction of Pd(II) from hydrochloric acid solution Pd(II) was extracted quant. with HMBMS in kerosene. Thiourea solution could be used as stripping agent. Extraction parameters of Pd(II), including 2-hexyl-5-Me benziminazole sulfide (HMBMS) concentration, contact time of aqueous and organic phases, organic/aqueous (O/A) phase ratio and hydrochloric acid concentration of aqueous phase, were studied in detail. The extraction saturation capacity of Pd(II) was determined from 0.1mol L-1 HCl solution with 30% (volume/volume) HMBMS and its exptl. value exceeded 10 g L-1 under the exptl. conditions. Pd(II) and Pt(IV) could be separated effectively and the separation coefficient of Pd(II) and Pt(IV) (ssPd/Pt) reached 1.5×104 when HMBMS and HC1 concentration were fixed at 20% (V/V) and 0.1 mol L-1, resp. Stripping of Pd(II) from loaded organic phase was performed using thiourea solution

Different reactions of this compound(2-Mercapto-5-methylbenzimidazole)Related Products of 27231-36-3 require different conditions, so the reaction conditions are very important.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Oriental Journal of Chemistry called Novel and improved method for the synthesis of 2-mercaptobenzimidazole derivatives, Author is El Kihel, A.; Sir, H. Ait; Jebbari, S.; Ahbala, M.; Guesmi, S.; Bauchat, P., which mentions a compound: 27231-36-3, SMILESS is SC1=NC2=CC(C)=CC=C2N1, Molecular C8H8N2S, Product Details of 27231-36-3.

2-Mercaptobenzimidazole derivatives were synthesized by reaction of o-phenylenediamines with N-aminorhodanine. This reaction represented a new synthesis of 2-mercaptobenzazole. The structure of the obtained products was established by spectroscopic data.

Different reactions of this compound(2-Mercapto-5-methylbenzimidazole)Product Details of 27231-36-3 require different conditions, so the reaction conditions are very important.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Sakemi, Kazue; Ito, Rieno; Umemura, Takashi; Ohno, Yasuo; Tsuda, Mitsuhiro published the article 《Comparative toxicokinetic/toxicodynamic study of rubber antioxidants, 2-mercaptobenzimidazole and its methyl substituted derivatives, by repeated oral administration in rats》. Keywords: ercaptobenzimidazole derivative thyroid toxicity toxicokinetics.They researched the compound: 2-Mercapto-5-methylbenzimidazole( cas:27231-36-3 ).Reference of 2-Mercapto-5-methylbenzimidazole. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:27231-36-3) here.

2-Mercaptobenzimidazole (MBI), a rubber antioxidant, is known to exhibit potent thyroid toxicity in rats, whereas its methylated derivatives are much less toxic. To characterize this methyl-substituent effect on the thyroid toxicity of MBI, comparative toxicokinetic analyses have been conducted in the present study. MBI and the MMBIs [4-methylated MBI (4-MMBI) and 5-methylated MBI (5-MMBI), and a 1:1 mixture of these 4- and 5-methylated isomers (MMBI mix)] suspended in corn oil were repeatedly administered (at 0.3-0.6 mmol/kg) to male Wistar rats by gavage once daily for 2 wk. After the first and last administrations, blood and urine samples were collected, and the levels of unchanged compounds and their desulfurated metabolites were determined by high performance liquid chromatog. After repeated oral administration (roa), the Cmax and area under concentration-time curve (AUC) of MBI were markedly increased, while the MMBIs essentially were cleared from the blood within 10 h. After roa, the Cmax and AUC of 4-MMBI decreased markedly, suggesting metabolic enzyme induction. However, the toxicokinetic parameters of 5-MMBI were not markedly altered by roa. The inhibitory potencies (IC50) against lactoperoxidase of MBI, 4-MMBI, and 5-MMBI were 20.6 μM, 45.6 μM and 31.6 μM, resp. Thus, the authors suggest that the marked decrease of thyroid toxicity by Me substitution of MBI is caused mainly by a decrease in systemic exposure to the compounds and partly by a decrease in inhibition of thyroid hormone synthesis.

After consulting a lot of data, we found that this compound(27231-36-3)Reference of 2-Mercapto-5-methylbenzimidazole can be used in many types of reactions. And in most cases, this compound has more advantages.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Most of the compounds have physiologically active properties, and their biological properties are often attributed to the heteroatoms contained in their molecules, and most of these heteroatoms also appear in cyclic structures. A Journal, Tetrahedron Letters called Imidazobenzothiazine and primidobenzothiazine derivatives synthesis via an aliphatic SN2 substitution/Cu(I) catalyzed Ullmann coupling cascade process, Author is Wang, Ruihong; Qian, Weixing; Bao, Weiliang, which mentions a compound: 27231-36-3, SMILESS is SC1=NC2=CC(C)=CC=C2N1, Molecular C8H8N2S, COA of Formula: C8H8N2S.

An efficient method for the preparation of various imidazobenzothiazine and primidobenzothiazine derivatives from readily available 2-mercaptoimidazoles (thiouracils) and bromobenzyl bromides via a copper(I)-catalyzed one-pot cascade process has been developed. The reaction involves a SN2 process and an intramol. C-N cross coupling cyclization.

Although many compounds look similar to this compound(27231-36-3)COA of Formula: C8H8N2S, numerous studies have shown that this compound(SMILES:SC1=NC2=CC(C)=CC=C2N1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Demirayak, Seref; Tuncel, Muzaffer; Ogretir, Cemil published an article about the compound: 2-Mercapto-5-methylbenzimidazole( cas:27231-36-3,SMILESS:SC1=NC2=CC(C)=CC=C2N1 ).Electric Literature of C8H8N2S. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:27231-36-3) through the article.

The reaction kinetics of some 5(6)-substituted benzimidazole-2-thiones with chloroacetic acid forming thioethers in basic media were studied to elucidate the effect of substituents on 5(6)-positions. To achieve this, the substituent effects on thiolactam-thiolactim equilibrium were determined by measuring the acidity constants (i.e. pKa values) of the compounds Following that, the carboxymethylation rates were measured at elevated temperature and pH values. Excluding the nitro group, the expected substituent effects were observed

Although many compounds look similar to this compound(27231-36-3)Electric Literature of C8H8N2S, numerous studies have shown that this compound(SMILES:SC1=NC2=CC(C)=CC=C2N1), has unique advantages. If you want to know more about similar compounds, you can read my other articles.

Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem