Category: 27231-36-3

Application In Synthesis of 2-Mercapto-5-methylbenzimidazole. Aromatic compounds can be divided into two categories: single heterocycles and fused heterocycles. Compound: 2-Mercapto-5-methylbenzimidazole, is researched, Molecular C8H8N2S, CAS is 27231-36-3, about An expeditious microwave-assisted synthesis of mercapto benzazoles, quinazolinone and oxadiazoles. Author is Kumar, N. D. Mahesh; Dubey, P. K..

A simple, convenient, and high-yielding synthetic method for the preparation of mercapto derivatives of benzimidazoles, benzoxazole, benzothiazole, and quinazolinone as well as 5-substituted 1,3,4-oxadiazoles by the treatment of a series of O-, S-, and N-heteroatom-containing bifunctional mols., i.e. functionalized anilines and aromatic hydrazides, resp., with KS2COCHMe2 under microwave irradiation is described.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Recommanded Product: 2-Mercapto-5-methylbenzimidazole. The mechanism of aromatic electrophilic substitution of aromatic heterocycles is consistent with that of benzene. Compound: 2-Mercapto-5-methylbenzimidazole, is researched, Molecular C8H8N2S, CAS is 27231-36-3, about n-type organic thin-film transistors with self-assembled monolayers. Author is Kim, Seong Hyun; Lee, Jung Hun; Yang, Yong Suk; Lee, Jeong-Ik; Zyung, Taehyoung.

Contact properties between the organic semiconductor and the metal source- and drain-contact are one of the most important issues since the charge carrier injection through the contact has serious effects on the device performance. Au surfaces of the source- and drain-electrodes are modified by self-assembled monolayers (SAM) using thiol derivatives The charge carrier mobility using n-type organic semiconductor was increased from 4.3 × 10-4 to 4.8 × 10-3 cm2/Vs after modification of the source- and drain-electrodes. Better contact properties between the metal electrodes and organic semiconductors could improve the device performance.

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Benzoxazole – Wikipedia,
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Miyajima, Atsuko; Sakemi-Hoshikawa, Kazue; Usami, Makoto; Mitsunaga, Katsuyoshi; Irie, Tomohiko; Ohno, Yasuo; Sunouchi, Momoko published an article about the compound: 2-Mercapto-5-methylbenzimidazole( cas:27231-36-3,SMILESS:SC1=NC2=CC(C)=CC=C2N1 ).Category: benzoxazole. Aromatic heterocyclic compounds can be classified according to the number of heteroatoms or the size of the ring. The authors also want to convey more information about this compound (cas:27231-36-3) through the article.

We examined the effects of thyrotoxic rubber antioxidants, 2-mercaptobenzimidazole (MBI, 0.3 mmol/kg/day) and its Me derivatives, methyl-MBIs [4-methyl-MBI (4-MeMBI, 0.6 mmol/kg/day), 5-methyl-MBI (5-MeMBI, 0.6 mmol/kg/day), and 4(or 5)-methyl-MBI (4(5)-MeMBI, 0.6 or 1.2 mmol/kg/day)], on the drug-metabolizing activity in male rat liver microsomes by 8-day repeated oral administration. The weight of liver and thyroid were increased by all the test chems.; MBI was most potent, and there was no additive or synergistic effect between 4-MeMBI and 5-MeMBI. MBI decreased the cytochrome P 450 (CYP) content, NADPH-cytochrome P 450 reductase (POR) activity, 7-ethoxycoumarin O-deethylation (ECOD) activity, and flavin-containing monooxygenase (FMO) activity, but increased the 7-pentoxyresorufin O-depentylation (PROD) activity, suggesting inhibition of the drug-metabolizing activity on the whole but induce some activities such as the CYP2B activity. On the contrary, all the methyl-MBIs increased the CYP content, CYB5 content, ECOD activity, 7-ethoxyresorufin O-deethylation (EROD) activity, and PROD activity, indicating that they are mostly inducible of the CYP activity. However, the methyl-MBIs decreased the FMO activity, and 5-MeMBI and 4(5)-MeMBI appeared inhibitory for CYPs 2C11 and 2C13. Between 4-MeMBI and 5-MeMBI, there was no additive or synergistic effect on the drug-metabolizing activity, but was counteraction. It was concluded that MBI and methyl-MBIs had both inhibitory and inducible effects on the drug-metabolizing activity in rat liver microsomes at thyrotoxic doses. The effects of 4(5)-MeMBI indicated that the increased liver weight alone can be a hepatotoxic sign but not an adaptive no-adverse response in toxicity studies. The present results were related to the toxicokinetic profiles of MBI and 4(5)-MeMBI in the repeated toxicity studies.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Most of the natural products isolated at present are heterocyclic compounds, so heterocyclic compounds occupy an important position in the research of organic chemistry. A compound: 27231-36-3, is researched, SMILESS is SC1=NC2=CC(C)=CC=C2N1, Molecular C8H8N2SJournal, Article, Toxicology Reports called Inhibitory and inductive effects of 4- or 5-methyl-2-mercaptobenzimidazole, thyrotoxic and hepatotoxic rubber antioxidants, on several forms of cytochrome P450 in primary cultured rat and human hepatocytes, Author is Miyajima, Atsuko; Kuroda, Yukie; Sakemi-Hoshikawa, Kazue; Usami, Makoto; Mitsunaga, Katsuyoshi; Irie, Tomohiko; Ohno, Yasuo; Sunouchi, Momoko, the main research direction is cytochrome P450 4MeMB 5MeMB hepatocyte Primary culture benzimidazole; 3-MC, 3-methylcholanthrene; 4(5)-MeMBI, 4(or 5)-methyl-2-mercaptobenzimidazole; 4-MeMBI, 4-methyl-2-mercaptobenzimidazole; 5-MeMBI, 5-methyl-2-mercaptobenzimidazole; AhR, aryl hydrocarbon receptor; Benzimidazole; CYP, cytochrome P450; Cytochrome P450; DMSO, dimethyl sulfoxide; Drug-metabolizing activity; EROD, 7-ethoxyresorufin O-deethylation; Hepatocyte; MBI, 2-mercaptobenzimidazole; PXR, pregnane X receptor; Primary culture; T6βH, testosterone 6β-hydroxylation.Product Details of 27231-36-3.

Effects of 4-methyl-2-mercaptobenzimidazole (4-MeMBI) and 5-methyl-2- mercaptobenzimidazole (5-MeMBI) on cytochrome P 450 (CYP) activity were examined in primary cultured rat hepatocytes. Hepatocytes from male Wistar rats were cultured in the presence of 4-MeMBI or 5-MeMBI (0-400μM), and the activity of CYPs 3A2/4 (48 and 96 h) and 1A1/2 (48 h) was determined by measuring the activity of testosterone 6β-hydroxylation and 7-ethoxyresorufin O-deethylation, resp. As a result, 4-MeMBI and 5-MeMBI (≥12.5μM) inhibited CYP3A2 activity. On the other hand, 4-MeMBI (≥25μM) and 5-MeMBI (≥100μM) induced CYP1A1/2 activity, being consistent with the previous in vivo results. In a comparative metabolism study using primary cultured human hepatocytes from two Caucasian donors, 4-MeMBI and 5-MeMBI induced the activity of CYPs 3A4 and 1A1/2 with individual variability. It was concluded from these results that 4-MeMBI, 5-MeMBI and MBI caused inhibition of CYP3A2 activity in primary cultured rat hepatocytes, suggesting their potential for metabolic drug-drug interactions. Primary cultured rat and human hepatocytes were considered to be useful for the evaluation of effects of the benzimidazole compounds on their inducibility and inhibitory activities of cytochrome P 450 forms.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Category: benzoxazole. The reaction of aromatic heterocyclic molecules with protons is called protonation. Aromatic heterocycles are more basic than benzene due to the participation of heteroatoms. Compound: 2-Mercapto-5-methylbenzimidazole, is researched, Molecular C8H8N2S, CAS is 27231-36-3, about Electrochemical study of 2-mercaptoimidazole as a novel corrosion inhibitor for steels. Author is Alvarez-Bustamante, R.; Negron-Silva, G.; Abreu-Quijano, M.; Herrera-Hernandez, H.; Romero-Romo, M.; Cuan, A.; Palomar-Pardave, M..

From electrochem. methods, polarization resistance and electrochem. impedance spectroscopy, the corrosion susceptibility of pipeline steel samples immersed in 1 M H2SO4 was determined using nil and different concentrations of the mol. 2-mercaptoimidazole (2MI). A corrosion inhibiting efficiency, IE, value of 98.5% was reached when the 2MI concentration in the system increased to 25 ppm. Also, at this concentration, the 2MI IE was measured as a function of time finding that the IE kinetics follows the relation: %IE = 98.5-0.03t after 800 h of evaluation. During the 1st 200 h 2MI IE was higher that 90% then, it decreased to 70% and it remained constant up to 1200 h. This compound can affect both the anodic and cathodic processes, thus it can be classified as a mixed-type inhibitor however, from variation of both corrosion potential and polarization resistance with [2MI] it was possible to state that the anodic reaction rate, of the corrosion process, decreases at a greater proportion than the cathodic one. 2MI follows an adsorption mechanism, which can be adequately described by the Langmuir isotherm with an adsorption standard free energy difference (ΔG°ads) of -26.8 kJ mol-1. To analyze the influence of substituting groups, both electron-donating and electron-attracting and the number of π-electrons on the corrosion inhibiting properties of organic mols., an electrochem. study was carried out on four different mols. having similar chem. framework structure: 2-mercaptoimidazole (2MI), 2-mercaptobenzoimidazole (2MBI) 2-mercapto-5-methylbenzimidazole (2M5MBI) and 2-mercapto-5-nitrobenzimidazole (2M5NBI). The IE order followed by the mols. tested was 2MI > 2MBI > 2M5MBI > 2M5NBI. Thus 2MI turned out to be the best inhibitor, even superior to the 2MBI. This fact strongly suggests that, contrary to a hitherto generally suggested notion, an efficient corrosion inhibiting mol. does not require to be a large one, also bearing an extensive number of π-electrons.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

The chemical properties of alicyclic heterocycles are similar to those of the corresponding chain compounds. Compound: 2-Mercapto-5-methylbenzimidazole, is researched, Molecular C8H8N2S, CAS is 27231-36-3, about Design, synthesis and biological evaluation of benzimidazole/benzothiazole and benzoxazole derivatives as cyclooxygenase inhibitors, the main research direction is mercaptobenzimidazole benzyl alc etherification; benzimidazole thioether preparation cyclooxygenase inhibitor; mercaptobenzothiazole benzyl alc etherification; benzothiazole thioether preparation cyclooxygenase inhibitor; mercaptobenzoxazole benzyl alc etherification; benzoxazole thioether preparation cyclooxygenase inhibitor.SDS of cas: 27231-36-3.

A series of 2-[[(2-alkoxy-6-pentadecylphenyl)methyl]thio]-1H-benzimidazoles, benzothiazoles and benzoxazoles have been prepared from anacardic acid and their ability to inhibit human cyclooxygenase-2 enzyme (COX-2) investigated. The active compounds were screened for cyclooxygenase-1 (COX-1) inhibition. I (X = NH; R1 = H; R2 = OMe) is 384-fold and I (X = S; R1 = Me; R2 = H) is more than 470-fold selective towards COX-2 compared to COX-1. Thus, this class of compounds may serve as excellent candidates for selective COX-2 inhibition.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Recommanded Product: 2-Mercapto-5-methylbenzimidazole. So far, in addition to halogen atoms, other non-metallic atoms can become part of the aromatic heterocycle, and the target ring system is still aromatic. Compound: 2-Mercapto-5-methylbenzimidazole, is researched, Molecular C8H8N2S, CAS is 27231-36-3, about Microwave-assisted synthesis of 3-[2-(1H-benzimidazol-2-yl-sulfanyl)-acetyl]-chromen-2-ones.

Synthesis of some new 3-[2-(1H-benzimidazol-2-yl-sulfanyl)-acetyl]-chromen-2-ones by treatment of 2-mercaptobenzimidazoles with 3-(2-bromoacetyl)chromen-2-one under microwave irradiation technique was described.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Jiang, Yu-Han; Qiu, Qi-Ming; Jiang, Rui-Xia; Huang, Xu; Jin, Qiong-Hua published the article 《Iodido[5-methyl-1H-benzimidazole-2(3H)-thione-κS]bis(triphenylphosphane-κP)copper(I) methanol monosolvate》. Keywords: mol structure copper iodido methylbenzimidazolethione triphenylphosphine complex methanol solvate; crystal structure copper iodido methylbenzimidazolethione triphenylphosphine complex methanol solvate; hydrogen bond copper iodido methylbenzimidazolethione triphenylphosphine complex methanol solvate.They researched the compound: 2-Mercapto-5-methylbenzimidazole( cas:27231-36-3 ).Quality Control of 2-Mercapto-5-methylbenzimidazole. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:27231-36-3) here.

In the title compound, [CuI(C8H8N2S)(C18H15P)2]·MeOH, the coordination environment around the CuI atom is distorted tetrahedral, defined by two P atoms of two PPh3 ligands, one S atom of a 5-methyl-1H-benzimidazole-2(3H)-thione ligand and one I atom. The complex mols. and the MeOH solvent mols. are connected via N-H···O and O-H···I H bonds, forming a chain along [010]. An intramol. N-H···I H bond is also observed Crystallog. data and at. coordinates are given.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Quality Control of 2-Mercapto-5-methylbenzimidazole. Aromatic heterocyclic compounds can also be classified according to the number of heteroatoms contained in the heterocycle: single heteroatom, two heteroatoms, three heteroatoms and four heteroatoms. Compound: 2-Mercapto-5-methylbenzimidazole, is researched, Molecular C8H8N2S, CAS is 27231-36-3, about Synthesis, characterization, and biological activities of homo- and heterobimetallic complexes of Sn(IV) and Pd(II) with 2-mercapto-5-methylbenzimidazole. Author is Rafiq, M.; Ali, S.; Shahzadi, S.; Shahid, M.; Sharma, S. K.; Qanungo, K..

Organotin complexes have been synthesized by refluxing 2-mercapto-5-methylbenzimidazole with R2SnCl2/R3SnCl (R = Me, n-Bu, Ph) in 1:1 molar ratio in the first step. In the second step, synthesized organotin(IV) complexes were treated with CS2 and R2SnCl2/R3SnCl/PdCl2 to yield homo- and heterobimetallic complexes. The composition of the synthesized complexes, the bonding behavior of the donor groups, and structural assignments were studied by elemental anal. and different spectral techniques, including IR and multinuclear NMR (1H, 13C). The IR data shows bidentate nature of the ligand which is also confirmed by semiempirical study, while NMR data confirms the four-coordinated geometry in solution The free ligand and its resp. homo- and heterobimetallic complexes were screened in vitro against a number of microorganisms to assess their biocidal properties. The biol. activity data show that complexes exhibits significant antibacterial and antifungal activities as compared to ligand with few exceptions.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Lozanova, H. S.; Vassilev, G. N. published the article 《Synthesis and growth-regulating activity of some new 2-(β-ketopropyl)-mercaptobenzimidazols and their oximes》. Keywords: benzimidazolyl mercapto propanone preparation growth regulator herbicide; propanone oxime benzimidazole mercapto preparation growth regulator herbicide.They researched the compound: 2-Mercapto-5-methylbenzimidazole( cas:27231-36-3 ).Application of 27231-36-3. Aromatic heterocyclic compounds can be divided into two categories: single heterocyclic and fused heterocyclic. In addition, there is a lot of other information about this compound (cas:27231-36-3) here.

A new original method for synthesis of some 2-(β-ketopropyl)-mercaptobenzimidazols and their oximes is reported. The procedure is easy to perform and gives a possibility to variate the substituents. The substances have inhibiting activity to both test-objects in concentration 10-3 mol dm-3 and high stimulating activity to monocotyledonous test wheat.

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Reference:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem