Category: 27383-86-4

As a common heterocyclic compound, it belongs to benzoxazole compound, name is Methyl benzo[d]oxazole-2-carboxylate, and cas is 27383-86-4, its synthesis route is as follows.

Benzoxazole-2-carboxylic acid hydrazide (4): To a mixture of 3 (0.01 mol) in 10 mL of absolute ethanol and hydrazine hydrate (0.04 mol) was added. Then the reaction mixture was refluxed for 8 h. After completion of the reaction (monitored by TLC), it was then diluted with ice-cold water (20 mL) and the solid obtained was purified by crystallization from ethanol to afford pure product benzoxazole-2-carboxylic acid hydrazide 4. Benzoxazole-2-carboxylic acid N’-acetyl hydrazide (5a-d): To a solution of 4 (0.01 mol) in dioxane (10 mL) corresponding benzoyl chloride (0.01 mol) was added.

27383-86-4, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,27383-86-4 ,Methyl benzo[d]oxazole-2-carboxylate, other downstream synthetic routes, hurry up and to see

Reference：
Article; Vodela, Sunil; Mekala, Raghu Vardhan Reddy; Danda, Ravinder Reddy; Kodhati, Venkateshwarlu; Chinese Chemical Letters; vol. 24; 7; (2013); p. 625 – 628;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

27383-86-4, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. Methyl benzo[d]oxazole-2-carboxylate, cas is 27383-86-4,the benzoxazole compound, it is a common compound, a new synthetic route is introduced below.

A stirred solution of 2-aminophenol (300 mg, 2.75 [MMOL), METHYL] 2,2, 2- trimethoxyacetate (902 mg, 5.50 [MMOL),] and ytterbium [TRIFLATE] (170 mg, 0.28 [MMOL)] in [TOLUENE] (10 mL) was heated to reflux. After 5 h, the mixture was cooled, and the precipitate was collected and dried. The crude solid was suspended in toluene (5 mL), and [N-METHYLPIPERAZINE] (1.5 mL, 13.7 [MMOL)] was added followed by 2-hydroxypyridine (26 mg, 0.28 [MMOL).] The mixture was heated to 125 [°C] in a sealed tube for 4 h. The resulting yellow solution was concentrated under reduced pressure, and the residue was purified on silica gel (12 g; 2percent methanol/dichloromethane), yielding 320 mg (48percent) of the title compound. MS [(ESI)] : mass calculated for [C13H15N302,] 245.12 ; m/z found, 246.1 [[M+H] +. 1H] NMR (400 MHz, [CDC13)] : 7.83-7. 79 (m, 1 H), 7.66-7. 65 [(M,] 2H), 7.47-7. 41 (m, 2H), 4.19 (t, [J = 5.] 1 Hz, 4H), 3.88 (t, [J = 5.] 1 Hz, 4H), 2.55- 2.52 [(M,] 4H), 2.35 (s, 3H). [13C] NMR (400 MHz, [CDCI3)] : 156.1, 154.6, 149. 9, 140.1, 127.1, 125.3, 121. [3,] 111.5, 55.3, 54.6, 46.9, 45.9, 42.8.

The chemical industry reduces the impact on the environment during synthesis,27383-86-4,Methyl benzo[d]oxazole-2-carboxylate,I believe this compound will play a more active role in future production and life.

Reference：
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2004/22060; (2004); A2;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Name is Methyl benzo[d]oxazole-2-carboxylate, as a common heterocyclic compound, it belongs to benzoxazole compound, and cas is 27383-86-4, its synthesis route is as follows.,27383-86-4

A stirred solution of 2-aminophenol (300 mg, 2.75 [MMOL), METHYL] 2,2, 2- trimethoxyacetate (902 mg, 5.50 [MMOL),] and ytterbium [TRIFLATE] (170 mg, 0.28 [MMOL)] in [TOLUENE] (10 mL) was heated to reflux. After 5 h, the mixture was cooled, and the precipitate was collected and dried. The crude solid was suspended in toluene (5 mL), and [N-METHYLPIPERAZINE] (1.5 mL, 13.7 [MMOL)] was added followed by 2-hydroxypyridine (26 mg, 0.28 [MMOL).] The mixture was heated to 125 [¡ãC] in a sealed tube for 4 h. The resulting yellow solution was concentrated under reduced pressure, and the residue was purified on silica gel (12 g; 2percent methanol/dichloromethane), yielding 320 mg (48percent) of the title compound. MS [(ESI)] : mass calculated for [C13H15N302,] 245.12 ; m/z found, 246.1 [[M+H] +. 1H] NMR (400 MHz, [CDC13)] : 7.83-7. 79 (m, 1 H), 7.66-7. 65 [(M,] 2H), 7.47-7. 41 (m, 2H), 4.19 (t, [J = 5.] 1 Hz, 4H), 3.88 (t, [J = 5.] 1 Hz, 4H), 2.55- 2.52 [(M,] 4H), 2.35 (s, 3H). [13C] NMR (400 MHz, [CDCI3)] : 156.1, 154.6, 149. 9, 140.1, 127.1, 125.3, 121. [3,] 111.5, 55.3, 54.6, 46.9, 45.9, 42.8.

With the complex challenges of chemical substances, we look forward to future research findings about Methyl benzo[d]oxazole-2-carboxylate

Reference£º
Patent; JANSSEN PHARMACEUTICA, N.V.; WO2004/22060; (2004); A2;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem