Category: 301353-96-8

Research speed reading in 2021. Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, new energy materials, preparation and modification of special coatings. 301353-96-8, Name is P7C3, molecular formula is , belongs to benzoxazole compound. In a document, author is Spengler, Gabriella, Category: benzoxazole.

Background/Aim: Multidrug resistance (MDR) represents a significant impediment to successful cancer treatment. In this study, novel metal [Zn(II), Cu(II), Mg(II), Ni(II), Pd(II), and Ag(I)] complexes of 2-trifluoroacetonyl-benzoxazole previously synthesized and characterized by our group were tested for their MDR-reversing activity in comparison with the free ligands in L5178Y mouse T-lymphoma (MDR) cells transfected with human ATP-binding cassette sub family B member 1 (ABCB1; P-glycoprotein) gene. Materials and Methods: Cytotoxic and antiproliferative effects of the complexes were assessed by the thiazolyl blue tetrazolium bromide (MTT) method. Modulation of ABCB1 activity was measured by rhodamine 123 accumulation assay using flow cytometry. The apoptosis-inducing activity of some complexes was also tested on the multidrug resistant L5178Y mouse T-lymphoma cells, using the annexin-V/propidium iodide assay. Results: When compared to the free ligand, a remarkable enhancement in MDR reversal and cytotoxic activity was found for the Zn(II) and Cu(II) complexes. The activity of the complexes proved to be up to 29- and 5-fold higher than that of the ligands and the ABCB1 inhibitor verapamil as positive control, respectively. The complexes possessed a remarkable potential to induce apoptosis of MDR cells. Conclusion: Our results suggest that the Zn(II) and Cu(II) complexes display significant MDR-reversing activity in a dose-dependent manner and possess strong cytotoxic activity and a remarkable potential to induce apoptosis in MDR L5178Y mouse T-lymphoma cells.

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Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

New Advances in Chemical Research in 2021.The dynamic chemical diversity of the numerous elements, ions and molecules that constitute the basis of life provides wide challenges and opportunities for research. 301353-96-8, Name is P7C3, molecular formula is , belongs to benzoxazole compound. In a document, author is Meenakshi, Formula: https://www.ambeed.com/products/301353-96-8.html.

Reaction of Al(OPri)(3) with 2-(o-hydroxy phenyl)-benzimidazole (pbmzH) and 2-(o-hydroxy phenyl)-benzothiazole (pbtzH) in different molar ratio in benzene solution afforded complex of the types [(mu-OPri)Al-2(pbmz)(2)(OPri)(2)] 1, [Al(OPri)(pbmz)(2)] 2, [Al(pbmz)(3)] 3, [(mu-OPri)Al-2(pbtz)(2)(OPri)(2)] 4, [Al(OPri)(pbtz)(2)] 5 and [Al(pbtz)(3)] 6. All these white to creamy white solid complexes are soluble in common organic solvents (such as C6H6, CCl4, n-hexane, DMSO, DMF etc.) and were characterized by elemental (C, H, N and AI) analysis as well as spectral [IR (H-1, C-13 and Al-27) NMR] and mass studies. On the basis of these spectroscopic data a plausible structure tentatively has been proposed for these complexes.

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Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products has revolutionised modern synthetic chemistry. In an article, author is Karaaslan, Cigdcm, once mentioned the application of 301353-96-8, Computed Properties of https://www.ambeed.com/products/301353-96-8.html, Name is P7C3, molecular formula is C21H18Br2N2O, molecular weight is 474.1884, category is benzoxazole. Now introduce a scientific discovery about this category.

Background: The benzazole nucleus is found in many promising small molecules such as anticancer and antibacterial agents. Bendamustine (Alkylating agent), Nocodazole (Mitotic inhibitor), Veliparib (PARP inhibitor), and Glasdegib (SMO inhibitor) are being clinically used as anticancer therapeutic which bear benzimidazole moiety. Based on the principle of bioisosterism, in the present work, 23 compounds belonging to 2-(3,4-dimethoxyphenyl)benzazoles and imidazopyridine series were synthesized and evaluated for their anticancer and antimicrobial activities. Objective: A series of new 2-(3,4-dimetboxyphenyl)-1H-benz(or pyrido)azoles were synthesized and evaluated for their anticancer and antimicrobial activities. Method: N-(5-chloro-2-hdroxyphenyl)-3,4-dimethoxybenzamide 1, was obtained by the amidation of 2-hydroxy-5-chloroaniline with 3,4-dimethoxybenzoic acid by using 1,1′-carbonyldiimidazole. Cyclization of 1 to benzoxazole derivative 2, was achieved by p-toluenesulfonic acid. Other 1H-benz(or pyrido)azoles were prepared by the reaction between 2-aminothiophenol, o-phenylenediamine, o-pyridinediamine with sodium metabisulfite adduct of 3,4-dimethoxybenzaldehyde. The NMR assignments of the dimethoxy groups were established by the NOESY spectra. Results: Compound 12, bearing two chlorine atoms at the 5(4) and 7(6) positions of the benzene moiety of benzimidazole was found the most potent analogue against A549 cells with the GI(50) value of 1.5 mu g/mL. Moreover, 24 showed remarkable cell growth inhibition against MCF-7 and HeLa cells with the GI(50) values of 7 and 5.5 mu g/mL, respectively. The synthesized compounds have no important antibacterial and antifimgal activities. Conclusion: It could be concluded that the introduction of di-chloro atoms at the phenyl ring of 2-(3,4-dimetboxyphenyl)-1H-benzimidawles increases significant cytotoxicity to selected human tumor cell lines in comparison to other all benzazoles synthesized. Unsubstituted 2-(3,4-dimethoxyphenyl)-imidazopyridines also gave good inhibitory profile against A549 and HeLa cells.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 301353-96-8, in my other articles. Computed Properties of https://www.ambeed.com/products/301353-96-8.html.

Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

New discoveries in chemical research and development in 2021. The appropriate choice of redox mediator can avoid electrode passivation and overpotential, which strongly inhibit the efficient activation of substrates in electrolysis.301353-96-8, Name is P7C3, molecular formula is C21H18Br2N2O. In an article, author is Liu, Guoqing,once mentioned of 301353-96-8, Category: benzoxazole.

Series of heterocyclic compounds containing ethynyl group, 2-[4-[2-[4-(alkoxy)phenyl]ethynyl]phenyl] -benzoxazole derivatives (nPEPBx), are prepared and investigated. They display enantiotropic nematic and smectic mesophases with large mesophase ranges of 30-133 degrees C (heating) and 31-141 degrees C (cooling). Compared with reference analogues without ethynyl group, the compounds nPEPBx roughly give lower melting points and much higher nematic mesophase stability because of the introduction of triple carbon-carbon bond. Meanwhile, they show much higher birefringence (Delta n, 0.50-0.65 and 0.55-0.68 for experimental and calculated values with density functional theory (DFT), respectively) than common tolane-based liquid crystals, which indicates that the introduction of benzoxazole unit is an effective method to enhance Delta n values of the rod-like molecule. It is concluded that nPEPBx has a potential application in liquid crystal mixture as a dopant to enhance the performance of the host mixture.

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Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

New discoveries in chemical research and development in 2021. The transformation of simple hydrocarbons into more complex and valuable products has revolutionised modern synthetic chemistry. In an article, author is Zhan, Zhenzhen, once mentioned the application of 301353-96-8, COA of Formula: https://www.ambeed.com/products/301353-96-8.html, Name is P7C3, molecular formula is C21H18Br2N2O, molecular weight is 474.1884, category is benzoxazole. Now introduce a scientific discovery about this category.

We have designed a general, inexpensive, and versatile method for the synthesis of (1H-benzo[d]imidazol2- yl)(phenyl)methanone and the formation of C-N bonds via an aromatic aldehyde and o-phenylenediamine. In the presence of N,N-dimethylformamide/sulfur, (1H-benzo[d]imidazol-2-yl)(phenyl)methanone was obtained; however, in the absence of sulfur, quinoxaline was obtained in 1,4-dioxane. A wide range of quinoxalines and (1H-benzo[d]imidazol-2-yl)(phenyl)methanones was obtained under mild conditions.

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Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

New research progress on 301353-96-8 in 2021.Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, new energy materials, preparation and modification of special coatings. 301353-96-8, Name is P7C3, molecular formula is , belongs to benzoxazole compound. In a document, author is Aydin, Abdullah, Application In Synthesis of P7C3.

In the molecular structure of the title compound, C24H19Cl2N3O4, the three C atoms of the central N, N-dimethylmethanamine moiety are bonded to the N atoms of the two 5-chloro-1,3-benzoxazol-2(3H)-one groups and to the methyl C atom of the methylbenzene group. One of the nine-membered 2,3-dihydro-1,3-benzoxazole rings and the phenyl ring are almost parallel to each other, making a dihedral angle of 5.30 (18)degrees, but they are almost normal to the mean plane of the other nine-membered 2,3-dihydro-1,3-benzoxazole ring, subtending dihedral angles of 89.29 (16) and 85.41 (18)degrees, respectively. The crystal structure features C-H center dot center dot center dot O hydrogen bonds and pi-pi stacking interactions [centroid-to-centroid distances = 3.5788 (19) angstrom, slippage = 0.438 and 3.7773 (16) angstrom, and slippage = 0.716 angstrom].

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

Research speed reading in 2021. Chemistry is a science major with cience and engineering. The main research directions are chemical synthesis, new energy materials, preparation and modification of special coatings. 301353-96-8, Name is P7C3, molecular formula is , belongs to benzoxazole compound. In a document, author is Yatam, Satyanarayana, Category: benzoxazole.

The oxadiazole linked benzoxazoles derivatives were designed using scaffold hopping approach and their molecular level interactions with both isoforms of cyclooxygenases, Cyclo OXygenase-1 (COX-1) and CycloOXygenase-2 (COX-2), were carried out using docking protocols. Mini library of oxadiazole linked benzoxazoles derivatives were synthesized and tested for their COX inhibitory activity by invitro enzyme assay. The results indicated that compound 2-(((5-(2,4-dichlorophenyl)-1,2,4-oxadiazol-3-yl)methyl)thio)benzo[d]oxazole (5h), 2-(((5-(4-nitrophenyl)-1,2,4-oxadiazol-3-yl)methyl)thio)benzo[d]oxazole (5j) and 2-(((5-(4-(trifluoromethyl)phenyl)-1,2,4-oxadiazol-3-yl)methyl)thio)benzo[d]oxazole (5k) selectively inhibited COX-2 enzyme. The compound 5j exhibited strong selective COX-2 inhibition (IC50=4.83 mu M) followed by compound 5h (IC50=5.10 mu M) and 5k (IC50=6.70 mu M). The invivo anti-inflammatory activity of compound 5j was found to have better efficiency than the standard drug Ibuprofen at both 3h and 5h intervals. The significant molecular level interactions with respect to position of benzoxazole, 1,2,4-oxadiazole and substituted aryl groups in both COX-1 and COX-2 active sites were discussed. Subsequently, 2,2-diphenyl-2-picrylhydrazyl (DPPH) anti-oxidant activity was also checked for all the compounds and the compound 5j was found to be good anti-oxidant among the series with an IC50 of 34.5 mu M.

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Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

New discoveries in chemical research and development in 2021. As an important bridge between the micro, chemistry is one of the main methods and means for humans to understand and transform the material world. In an article, author is Naikwade, Altafhusen, once mentioned the application of 301353-96-8, Safety of P7C3, category is benzoxazole. Now introduce a scientific discovery about this category.

Nano-magnetite supported N-heterocyclic carbene-copper complex with wingtip ferrocene has been prepared via multi-step procedure. The complex has been characterized by various analytical techniques such as fourier transform infrared (FT-IR), fourier transform Raman (FT-Raman), X-ray photoelectron spectroscopy (XPS), X-ray diffraction (XRD), transmission electron microscopy (TEM) and vibrating sample magnetometer (VSM) analysis. The catalytic activity of the complex has been exploited in intramolecular O-arylation of o-iodoanilides under heterogeneous conditions. The complex could be successfully recycled up to twelve consecutive cycles.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

New Advances in Chemical Research in 2021. Catalysts are in the same phase as the reactants. Enzymes are biological catalysts that produce large increases in reaction rates and tend to be specific for certain reactants and products. 301353-96-8, Name is P7C3, molecular formula is , belongs to benzoxazole compound. In a document, author is Ye, Lu, Application of 301353-96-8.

Flexible poly(benzoxazole-co-amide) (PBOA) gas separation hollow fiber membranes were successfully prepared deriving from ether-containing polyamide precursors by thermal densification with or without a supplementary coating treatment. Compared with polyimide precursors, thermally rearrangement in this work required lower treatment temperature but generated better mechanical properties. Both spinning process and thermal treatment conditions were systemically manipulated to intensify the membrane densification aiming at achieving greatly improved selectivity of the obtained TR-PBOA hollow fiber membranes. It was found that draft ratio had little contribution to selectivity enhancement. Separation performance was substantially improved when precursor fibers were dried using ethanol-hexane exchange method and then thermally treated at 350-390 degrees C TR hollow fibers obtained by combined thermal treatment with coating method exhibited the highest selectivity values in this study.

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Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem

New discoveries in chemical research and development in 2021. In classical electrochemical theory, both the electron transfer rate and the adsorption of reactants at the electrode control the electrochemical reaction. 301353-96-8, Name is P7C3, molecular formula is C21H18Br2N2O. In an article, author is Imaizumi, Takamichi,once mentioned of 301353-96-8, COA of Formula: https://www.ambeed.com/products/301353-96-8.html.

A structural class of 2-aminobenzoxazole derivatives possessing biphenyltetrazole was discovered to be potent human ChemR23 inhibitors. We initially tried to improve the potency of compound 1, which was found through in-house screening using the human plasmacytoid dendritic cell (pDC)-like cell line CAL-1. The introduction of a chiral methyl moiety at a benzylic position in a center of compound 1 showed a large impact on the inhibitory activity against calcium signaling of ChemR23 induced by the natural ligand chemerin. As a result of further investigations at the benzylic position, (R)-isomer 6b was found to show a 30-fold increased potency over desmethyl compound 1. In addition, an extensive structure-activity relationship study on the benzoxazole moiety successfully led to a further increase in the potency. The antagonistic effect of the compounds was based on the induction of ChemR23 internalization. In addition, we observed that compound 31, which contained an amide moiety on benzoxazole, inhibited chemotaxis of CAL-1 cells induced by chemerin in vitro. These results suggest that our ChemR23 inhibitors are attractive compounds for the treatment of pDC-related autoimmune diseases, such as systemic lupus erythematosus and psoriasis.

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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem