367-11-3, Name is 1,2-Difluorobenzene, molecular formula is C6H4F2, Safety of 1,2-Difluorobenzene, belongs to benzoxazole compound, is a common compound. In a patnet, author is Malunavar, Shruti S., once mentioned the new application about 367-11-3.
Facile access to libraries of diversely substituted 2-aryl-benzoxazoles/benzothiazoles from readily accessible aldimines via cyclization/cross coupling in imidazolium-ILs with Pd(OAc)(2) or NiCl2 (dppp) as catalyst
A two-step protocol involving Pd-catalyzed cyclization of readily accessible p-bromophenyl-aldimines to 2-bromophenyl-benzoxazole/benzothiazole in [BMIM][PF6] or [BMIM][BF4] as solvent, followed by the Suzuki, Heck, and Sonogashira cross-coupling reactions catalyzed by Pd or Ni is described that generates libraries of diversely substituted 2-aryl-/heteroaryl-benzoxazoles/benzothiazoles in respectable isolated yields under mild reaction conditions. The feasibility to perform the two-steps in sequence in one-pot starting from the aldimines is also demonstrated and the potential for recycling/reuse of the IL solvent is also shown. (C) 2019 Elsevier Ltd. All rights reserved.
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Reference:
Benzoxazole – Wikipedia,
,Benzoxazole | C7H5NO – PubChem