Category: 375369-14-5

As a common heterocyclic compound, it belongs to benzoxazole compound, name is 6-Bromobenzo[d]oxazole, and cas is 375369-14-5, its synthesis route is as follows.

(b) 6-{4-[l-{[(35)-l-(Cyclopropylcarbonyl)-3-pyrrolidinyl]methyl}-5- (trifluoromethyl)-lH-benzimidazol-2-yl]phenyl}-l,3-benzoxazole1 – { [(3 S)- 1 -(Cyclopropylcarbonyl)-3-pyrrolidinyl]methyl} -2-[4-(4,4,5 ,5-tetramethyl- 1,3,2- dioxaborolan-2-yl)phenyl]-5-(trifluoromethyl)-lH-benzimidazole (120 mg, 0.167 mmol) was dissolved in 1,4-dioxane (1.5 mL) in 5-mLmicrowave vial. 6-bromo-l,3-benzoxazole (33.0 mg, 0.167 mmol), PdCl2(dppf)-CH2Cl2 adduct (6.81 mg, 8.34 mu?omega), and 2 M aqueous potassium carbonate (0.250 mL, 0.501 mmol) were added with stirring. The vial was purged with nitrogen, sealed and heated at 100 C for 2 hr. The reaction mixture was allowed to cool to RT and was diluted with water (50 mL). The pH was adjusted to 7 with 1 N HC1 and the mixture was extracted with DCM (3 x 50 mL). The combined extracts were dried over sodium sulfate, evaporated to dryness, and purified by silica gel column chromatography using a gradient of 0-10% MeOH/DCM, followed by preparative reverse phase hplc using a gradient of 1% aqueous NH4OH/acetonitrile, to afford 18 mg of the titled compound. (LCMS m z 531.0, M+H).

375369-14-5, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,375369-14-5 ,6-Bromobenzo[d]oxazole, other downstream synthetic routes, hurry up and to see

Reference：
Patent; GLAXOSMITHKLINE LLC; HALLMAN, Jason; LAUDEMAN, Christopher; LIU, Ronggang; MILLER, Aaron; MOORE, Michael, Lee; DOCK, Steven; MUSSO, David; PARRISH, Cynthia; WO2011/56635; (2011); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Name is 6-Bromobenzo[d]oxazole, as a common heterocyclic compound, it belongs to benzoxazole compound, and cas is 375369-14-5, its synthesis route is as follows.

6-Bromobenzo[d]oxazole (0.600 g, 3.03 mmol), anhydrous potassium acetate (0.595 g, 6.06 mmol) and 4,4,4′,4′,5,5,5′,5′-octamethyl-2,2′-bi(1,3,2-dioxaborolane) (0.846 g, 3.33 mmol) were combined in dry dioxane (10 mL), and the mixture was sparged with nitrogen for 15 min. The reaction mixture was treated with Pd(dppf)Cl2 (0.124 mg, 0.152 mmol) and was heated to 90C for 16 h After cooling, the mixture was shaken with EtOAc (45 mL) and satd NaCl (10 mL) and was filtered to remove dark solids. The organic phase was dried and concentrated. Purification by silica gel chromatography with 0-30% EtOAc-hexane afforded the title compound as white crystals (600 mg, 74%): mp 79-81 C; NMR (400 MHz, CDCl3) delta 8.13 (s, 1H), 8.04 (s, 1H), 7.80 (qt, / = 3.3, 1.8 Hz, 2H), 1.37 (s, 12H); EIMS m/z 245.

375369-14-5, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,375369-14-5 ,6-Bromobenzo[d]oxazole, other downstream synthetic routes, hurry up and to see

Reference：
Patent; DOW AGROSCIENCES LLC; BELL, Jared; BUYSSE, Ann M.; DAEUBLE, John F.; ECKELBARGER, Joseph D.; EPP, Jeffrey B.; IRVINE, Nicholas M.; KISTER, Jeremy; LO, William C.; LOSO, Michael R.; LOWE, Christian T.; ROHANNA, John C.; SATCHIVI, Norbert M.; SIDDALL, Thomas L.; STEWARD, Kimberly M.; YERKES, Carla N.; (281 pag.)WO2019/84353; (2019); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

As a common heterocyclic compound, it belongs to benzoxazole compound, name is 6-Bromobenzo[d]oxazole, and cas is 375369-14-5, its synthesis route is as follows.

Example 326; N-(5-(benzo[d]oxazol-6-yl)-2-chloropyridin-3-yl)-4-fluorobenzenesulfonamide; To a microwave vial equipped with a stirbar and charged with 6-bromobenzo[d]oxazole (0.050 g, 0.25 mmol), cesium carbonate (0.25 g, 0.76 mmol), PdCl2(dppf)*DCM (0.037 g, 0.045 mmol), N-(2-chloro-5- (4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)pyridin-3-yl)-4-fluorobenzenesulfonamide (0.10 g, 0.25 mmol) in THF (3 ml) was added water (0.5 ml). The vial was capped and placed into CEM Microwave for 10 minutes at 100 C, while 100 watts of energy was supplied via Powermax (Simultaneous heating while cooling technology). The progress of the reaction was monitored by LC/MS, which showed desired material in the mixture. The mixture was diluted with water and the organic layer was extracted with DCM and brine solution. The organics were collected, dried over sodium sulfate, filtered and concentrated in vacuo. The crude was recrystallized from 5:1 DCM/MeOH and Hexanes to give N-(5- (benzo[d]oxazol-6-yl)-2-chloropyridin-3-yl)-4-fluorobenzenesulfonamide (0.040 g, 39% yield) as a tan crystalline solid. MS (ESI pos. ion) m/z: 404 (MH+).

375369-14-5, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,375369-14-5 ,6-Bromobenzo[d]oxazole, other downstream synthetic routes, hurry up and to see

Reference：
Patent; AMGEN INC.; WO2009/17822; (2009); A2;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, Computed Properties of C7H4BrNO, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 375369-14-5, Name is 6-Bromobenzo[d]oxazole, molecular formula is C7H4BrNO

Direct Copper-Catalyzed C-H Monofluoroalkylation of Benzoxazoles with 1-Fluoro-1-haloalkanes

The first example of direct C?H bond monofluoroalkylation with 1-fluoro-1-haloalkanes with no adjacent functional groups and with beta-hydrogens has been developed. This transformation offers a straightforward route for the synthesis of a series of monofluoroalkylated benzoxazoles.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Computed Properties of C7H4BrNO, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 375369-14-5, in my other articles.

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthetic Route of 375369-14-5, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.375369-14-5, Name is 6-Bromobenzo[d]oxazole, molecular formula is C7H4BrNO. In a article£¬once mentioned of 375369-14-5

PYRIDINE AND PYRIMIDINE CARBOXYLATE HERBICIDES AND METHODS OF USE THEREOF

Provided herein are pyridine and pyrimidine carboxylates and their derivatives, and compositions and methods of use thereof as herbicides.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 375369-14-5

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Related Products of 375369-14-5, Because a catalyst decreases the height of the energy barrier, its presence increases the reaction rates of both the forward and the reverse reactions by the same amount.375369-14-5, Name is 6-Bromobenzo[d]oxazole, molecular formula is C7H4BrNO. In a article£¬once mentioned of 375369-14-5

Cobalt-Catalyzed Cross-Dehydrogenative Coupling Reactions of (Benz)oxazoles with Ethers

The cobalt-catalyzed cross-dehydrogenative coupling of (benz)oxazoles and ethers is described. Access to some important bioactive heteroaryl ether derivatives was achieved using CoCO3 as an inexpensive catalyst at levels as low as 1.0 mol %. Investigation of the mechanism indicates a catalytic cycle involving a radical process.

A reaction mechanism is the microscopic path by which reactants are transformed into products. Each step is an elementary reaction. In my other articles, you can also check out more blogs about 375369-14-5

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

375369-14-5, Name is 6-Bromobenzo[d]oxazole, belongs to benzoxazole compound, is a common compound. Safety of 6-Bromobenzo[d]oxazoleIn an article, once mentioned the new application about 375369-14-5.

Selective Phosphoramidation and Phosphonation of Benzoxazoles via Sequence Control

A selective phosphoramidation and phosphonation of benzoxazole was developed with trialkyl phosphites in the presence of iodine under mild conditions. In the reaction, the transformation completes in 10 min at room temperature and the substrates are well tolerant, as 2-substituted azoles could afford the quaternary carbon-centered products. Significantly, phosphites could be selectively introduced into the C- and N-positions of the benzoxazoles by controlling the addition sequence and the ratio of substrates.

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 375369-14-5

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

375369-14-5, Name is 6-Bromobenzo[d]oxazole, belongs to benzoxazole compound, is a common compound. Safety of 6-Bromobenzo[d]oxazoleIn an article, once mentioned the new application about 375369-14-5.

Transition-Metal-Free Alkylation/Arylation of Benzoxazole via Tf2O-Activated-Amide

A transition-metal-free approach to the alkylation/arylation of benzoxazole was developed by employing Tf2O-activated-amide as the alkylating/arylating reagent. The mild reaction conditions, and particularly insensitivity to air and water, further enhance the synthetic potential in pharmaceutical synthesis. (Figure presented.).

Do you like my blog? If you like, you can also browse other articles about this kind. Thanks for taking the time to read the blog about 375369-14-5

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Electric Literature of 375369-14-5, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.375369-14-5, Name is 6-Bromobenzo[d]oxazole, molecular formula is C7H4BrNO. In a Article£¬once mentioned of 375369-14-5

Nickel-catalyzed decarboxylative arylation of heteroarenes through sp2 C-H functionalization

The direct decarboxylative arylation of hetereoarenes with benzoic acids through a nickel-catalyzed sp2 C-H functionalization process was developed. This process provides the first examples of decarboxylative cross-coupling reactions with aromatic acids through nickel catalysis and tolerates a variety of functional groups. Moreover, this method provides efficient access to 2-aryl-substituted azoles, an important structural unit in natural products, medicinal compounds, and functional materials.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 375369-14-5, and how the biochemistry of the body works.Electric Literature of 375369-14-5

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Synthetic Route of 375369-14-5, Chemistry is the experimental science by definition. We want to make observations to prove hypothesis. For this purpose, we perform experiments in the lab. 375369-14-5, Name is 6-Bromobenzo[d]oxazole,introducing its new discovery.

IMIDAZO [1,5-A]PYRIMIDINYL CARBOXAMIDE COMPOUNDS AND THEIR USE IN THE TREATMENT OF MEDICAL DISORDERS

The invention provides substituted imidazo[1,5-a]pyrimidinyl carboxamide and related organic compounds, compositions containing such compounds, medical kits, and methods for using such compounds and compositions to treat medical disorders, e.g., Gaucher disease, Parkinson’s disease, Lewy body disease, dementia, or multiple system atrophy, in a patient. Exemplary substituted imidazo[1,5-a]pyrimidinyl carboxamide compounds described herein include substituted 2-heterocyclyl-4-alkyl-imidazo[1,5-a]pyrirnidine-8-carboxamide compounds and variants thereof.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 375369-14-5, and how the biochemistry of the body works.Synthetic Route of 375369-14-5

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem