Archives for Chemistry Experiments of Benzo[d]oxazol-2-amine

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Iminoisoindolinone metal complex

Iminoisoindolinone metal complexes of formula STR1 wherein A represents a 5- or 6-membered heterocyclic radical which contains at least one further heteroatom and can be fused or doubled with benzene nuclei, M represents a divalent metal atom excluding the alkaline earth metals, X represents a hydrogen atom, Y represents a halogen atom, Z represents a nitro group, an alkoxycarbonyl group of 2 to 6 carbon atoms or a group of formula RY2 –, wherein R represents a hydrogen atom, an alkyl group of 1 to 6 carbon atoms which is substituted by an aryl radical or is unsubstituted, a cycloalkyl group of 5 to 6 carbon atoms, or represents an aryl group, and Y2 represents an oxygen or a sulphur atom, m and n are 0 to 4, p is 0 to 2, and the sum of m+n+p must be 4, which are useful for pigmenting high molecular organic material.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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ANTIBIOTIC COMPOUNDS

The present invention relates to antibiotic compounds of formula (I), to compositions containing these compounds and to methods of treating bacterial diseases and infections using the compounds. The compounds find application in the treatment of infection with, and diseases caused by, Gram-positive and/or Gram-negative bacteria, and in particular in the treatment of infection with, and diseases caused by, Neisseria gonorrhoeae.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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Ultrasound assisted simultaneous reduction and direct functionalization of graphene oxide with thermal and cytotoxicity profile

The new sonochemical approach for simultaneous reduction and direct functionalization of graphene oxide (GrO) has been developed. The GrO was functionalized with 2-Aminobenzoxazole (2-ABOZ) in twenty min with complete deletion of hazardous steps. The significance of ultrasound was exemplified with the comparative conventional methods. The newly prepared f-(2-ABOZ)GrO was extensively characterized with near edge X-ray absorption fine structure (NEXAFS) spectroscopy, 13C solid state NMR, XPS, XRD, HRTEM, SAED, AFM, Raman, UV-vis, FTIR and TGA. The thermal stability of f-(2-ABOZ)GrO was confirmed with total percentage weight loss in TGA. The biological activity of f-(2-ABOZ)GrO was explored with MCF-7 and Vero cell lines. The inherent cytotoxicity was evaluated with SRB assay at 10, 20, 40 and 80 mug mL?1. The estimated cell viabilities were >78% with f-(2-ABOZ) GrO. A high cytocompatibility of f-(2-ABOZ)GrO was ensured with in vitro evaluation on living cell lines, and low toxicity of f-(2-ABOZ)GrO was confirmed its excellent biocompatibility. The morphological effect on Vero cell line evidently supports the formation of biocompatible f-(2-ABOZ)GrO. Therefore, f-(2-ABOZ)GrO was emerged as an advanced functional material for thermally stable biocompatible coatings.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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A facile synthesis of 2-aminobenzoxazoles and 2-aminobenzimidazoles using N -cyano- N -phenyl- P -toluenesulfonamide (NCTS) as an efficient electrophilic cyanating agent

A facile synthesis of 2-aminobenzoxazole and 2-aminobenzimidazole derivatives employing a nonhazardous electrophilic cyanating agent: N-cyano-N-phenyl-p-toluenesulfonamide (NCTS) with various substituted 2-aminophenols and benzene-1,2-diamine derivatives in the presence of lithium hexamethyldisilazide (LiHMDS) is described. This novel protocol boasts operational simplicity, shorter reaction time, and simple workup.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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FUSED OXAZOLE AND THIAZOLE DERIVATIVES AS TRPMS MODULATORS

The present invention provides fused oxazole and thiazole derivatives as TRPM8 (Transient Receptor Potential subfamily M, member 8) modulators. In particular, compounds described herein are useful for treating diseases, disorders, conditions modulated by TRPM8. Also provided herein are processes for preparing compounds described herein, intermediates used in their synthesis, pharmaceutical compositions thereof, and methods for treating or preventing diseases, conditions and/or disorders modulated by TRPM8.

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Benzoxazole – Wikipedia,
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Use of Electrochemistry in the Synthesis of Heterocyclic Structures

The preparation and transformation of heterocyclic structures have always been of great interest in organic chemistry. Electrochemical technique provides a versatile and powerful approach to the assembly of various heterocyclic structures. In this review, we examine the advance in relation to the electrochemical construction of heterocyclic compounds published since 2000 via intra- and intermolecular cyclization reactions.

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Benzoxazole – Wikipedia,
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PROCESS FOR THE CATALYTIC DIRECTED CLEAVAGE OF AMIDE-CONTAINING COMPOUNDS

The present invention relates to a catalytic method for the conversion of amide-containing compouds by means of a build-in directing group and upon the action of a heteronucleophilic compound (in se an amine (RNH2 or RNHR’) or an alcohol (ROH) or a thiol (RSH)) in the presence of a metal catalyst to respectively esters, thioesters, carbonates, thiocarbonates and to what is defined as amide-containing compounds (such as carboxamides, urea, carbamates, thiocarbamates). The present invention also relates to these amide-containing compounds having a build-in directing group (DG), as well as the use of such directing groups in the catalytic directed cleavage of N-DG amides with the use of heteronucleophiles (in se an amine (RNH2 or RNHR’) or an alcohol (ROH) or thiol (RSH)).

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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Contribution of edge structure towards enhanced thermal stability of graphene-based materials

An advanced approach for direct covalent functionalization (DCF) of graphene-based material has been developed. The functionalized graphene oxide (f-GO) has been prepared with the robust sonochemical approach with complete deletion of hazardous acylating and coupling reagents. The as-prepared f-GO was extensively characterized with various analytical techniques like near edge X-ray absorption fine structure (NEXAFS), 13C SSNMR, HRXPS, HRTEM, XRD, Raman, AFM, TGA, DSC and FTIR. An investigation of thermal applications of graphene-based materials has been confined due to the conventional thermal instability of graphene oxide (GO). However, DCF through contribution of C_K edges of graphene oxide, have confirmed the significance of f-GO towards enhanced thermal stability. The total percentage weight loss in TG-DTA has confirmed an enhanced thermal stability of f-GO. The contribution of edge structure towards enhanced thermal stability has confirmed with near edge XAFS spectroscopy. The participation of various atomic domains has synergistically contributed towards enhanced thermal stability of f-GO.

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Diketene a Privileged Synthon in the Synthesis of Heterocycles. Part 2: Six-Membered Ring Heterocycles

Diketene is an ideal molecule for use in many organic transformations, since it possesses electrophilic and nucleophilic sites which react with numerous functional groups. Diketene is mostly used as the common starting material for structurally diverse mono-, spiro-, and fused six-membered heterocycles such as lactones, pyrans, pyridines, quinolines, isoquinolines, oxazine, quinoxalines, benzothiazinone, 1,4-thiazidines, and oxazinonethione.

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Benzoxazole – Wikipedia,
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Visible-Light Photoswitching by Azobenzazoles

Three visible-light responsive photoswitches are reported, azobis(1-methyl-benzimidazole) (1), azobis(benzoxazole) (2) and azobis(benzothiazole) (3). Photostationary distributions are obtained upon irradiation with visible light comprising approximately 80 % of the thermally unstable isomer, with thermal half-lives up to 8 min and are mostly invariant to solvent. On protonation, compound 1H+ has absorption extending beyond 600 nm, allowing switching with yellow light, and a thermal half-life just under 5 minutes. The two isomers have significantly different pKa values, offering potential as a pH switch. The absorption spectra of 2 and 3 are insensitive to acid, although changes in the thermal half-life of 3 indicate more basic intermediates that significantly influence the thermal barrier to isomerization. These findings are supported by high-level ab initio calculations, which validate that protonation occurs on the ring nitrogen and that the Z isomer is more basic in all cases.

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Benzoxazole – Wikipedia,
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