Properties and Exciting Facts About Benzo[d]oxazol-2-amine

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Synthesis and benzodiazepine receptor binding of some imidazo-, pyrimido<2,1-b>benzoxazoles and pyrimido<1,2-a>benzimidazoles

A series of imidazo<2,1-b>benzoxazoles 3a-c, pyrimido<2,1-b>benzoxazoles 4-6, and pyrimido<1,2-a>benzimidazoles 7-9 was synthesized and evaluated for affinity at the benzodiazepine receptor (BZR).These compounds generally possess BZR binding affinities lower than those observed for the corresponding benzothiazole analogues.However, imidazobenzoxazole 3d possesses high binding affinity, showing an IC50 value of 77 nM.The pharmacological profile of 3d was predicted by <35S>TBPS binding as inverse agonist whereas antagonist or partial agonist activity was suggested by the GABA ratio value.Hence, a contrasting predictive capability of GABA ratio and <35S>TBPS binding was observed.Compound 3d should possess partial inverse agonist activity at BZR, because its <35S>TBPS binding data is comparable to those of FG-7142. – Keywords: imidazo<2,1-b>benzoxazole; pyrimido<2,1-b>benzoxazole; pyrimido<1,2-a>benzimidazole; central benzodiazepine receptor; peripheral benzodiazepine receptor; <35S>TBPS binding; GABA ratio.

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Related Products of 4570-41-6, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 4570-41-6, molcular formula is C7H6N2O, introducing its new discovery.

On water catalyst-free synthesis of benzo[: D] imidazo[2,1- b] thiazoles and novel N -alkylated 2-aminobenzo [d] oxazoles under microwave irradiation

A highly efficient unprecedented catalyst-free microwave-assisted procedure for synthesizing benzo[d]imidazo[2,1-b]thiazoles and N-alkylated 2-aminobenzo[d]oxazol in green media was developed. The transformation provided rapid access to functionalized benzo[d]imidazo[2,1-b]thiazoles from 2-aminobenzothiazole and N-alkylated 2-aminobenzo[d]oxazole from 2-aminobenzoxazole scaffolds under mild transition-metal-free conditions. This synthetic manipulation is expected to greatly expand the repertoire of reaction types in heterocyclic chemistry and pave the way for new syntheses of bioactive compounds.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Some scientific research about 4570-41-6

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Constructing heterocycles by visible light photocatalysis

Heterocycles are widely spread in natural products and in many bioactive compounds, as well as in a variety of fine chemicals. Synthesis through catalysis is always an advantageous strategy and today it is difficult to consider an approach to a target molecule without the inclusion of a catalytic step. Moreover, it is indeed almost a required characteristic for all the synthetic transformations in line with the principles of green chemistry and sustainable processes. Chemical transformations via visible light photocatalysis are emerging strategies that meet the increasing demand for more sustainable chemical processes. Up to date, several visible light approaches have been successfully applied to various organic transformations. Moreover, potential advantages are envisaged in this highly active new field. This review gives a brief overview of methods based on visible-light photoredox catalysis that have been developed for the synthesis of heterocycles using transition metal catalysts and organic catalysts. Only works in which at least one heterocycle is constructed are included, leaving the vast area of functionalization of heterocycles for other reviews.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Brief introduction of Benzo[d]oxazol-2-amine

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 4570-41-6, name is Benzo[d]oxazol-2-amine, introducing its new discovery. COA of Formula: C7H6N2O

Methylation of Amines and Ketones with Methanol Catalyzed by an Iridium Complex Bearing a 2-Hydroxypyridylmethylene Fragment

Reaction of complex [Cp?Ir(HOC5H3CH2C5H3OH)Cl][Cl] (1) with AgOTf generated the product [Cp?Ir(HOC5H3CH2C5H3OH)(H2O)][OTf]2 (2), which was further transformed to the complex [Cp?Ir(OC5H3CH2C5H3O)(H2O)] (3) in the presence of t-BuONa via -OH deprotonation. Complexes 1-3 exhibited high activity for the methylation of amines and ketones. These C-C and C-N coupling reactions proceeded in air with 1 mol % catalyst loading in the presence of K2CO3.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Awesome Chemistry Experiments For Benzo[d]oxazol-2-amine

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Synthesis and antimicrobial activity of amino linked heterocycles

Amino-linked benzoxazolyl/benzothiazolyl/benzimidazolyl quinazolines were prepared and their antimicrobial activity studied. The nitro-substituted benzothiazolyl quinazoline (8f) may be a potential antibacterial agent against Staphylococcus aureus and nitro-substituted benzimidazolyl quinazoline (9f) may be a potential antifungal agent against Aspergillus niger.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

More research is needed about Benzo[d]oxazol-2-amine

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NOVEL SALT OF FUSED PYRIMIDINE COMPOUND AND CRYSTAL THEREOF

Provided is a salt having a high selectivity to BTK and is useful as a drug ingredient for a pharmaceutical product. It has been found that fumarate of Compound A is free of a characteristic of channel hydrate and is stable and excellent in absorptive property, compared to Compound A or other salts thereof.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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Progress in the synthesis of 2-aminobenzoxazole derivatives

2-Aminobenzoxazole derivatives are a kind of heterocyclic compounds, which play important roles in medicine, biology and material science, and their synthetic methods have attracted much attention. In recent years, many efficient, green synthetic approaches of 2-aminobenzoxazole derivatives using transition-metal or metal-free catalytic systems have been reported. Based on differences of reaction substrates and synthetic methods, the recent advances in the synthesis of 2-aminobenzoxazole derivatives are reviewed.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Awesome and Easy Science Experiments about Benzo[d]oxazol-2-amine

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Efficient transposition of the sandmeyer reaction from batch to continuous process

The transposition of Sandmeyer chlorination from a batch to a safe continuous-flow process was investigated. Our initial approach was to develop a cascade method using flow chemistry which involved the generation of a diazonium salt and its quenching with copper chloride. To achieve this safe continuous process diazotation, a chemometric approach (Simplex method) was used and extrapolated to establish a fully continuous-flow method. The reaction scope was also examined via the synthesis of several (het)aryl chlorides. Validation and scale-up of the process were also performed. A higher productivity was obtained with increased safety.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Discovery of Benzo[d]oxazol-2-amine

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Rhodium-Catalyzed Chemo-, Regio-, and Enantioselective Allylation of 2-Aminothiazoles with Terminal Allenes

A rhodium-catalyzed chemo-, regio- and enantioselective intermolecular coupling reaction of 2-aminobenzothiazoles with terminal allenes is reported. The new reaction displays a wide substrate scope for both reaction partners to deliver the allylation products in good yields, with excellent regio- and enantioselectivity. This novel methodology was further applied in an efficient synthesis of chiral isothiourea.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

New explortion of Benzo[d]oxazol-2-amine

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Synthesis and antioxidant activity of amido-linked benzoxazolyl/ benzothiazolyl/benzimidazolyl-pyrroles and pyrazoles

The amido-linked benzoxazolyl/benzothiazolyl/benzimidazolyl-pyrroles and benzoxazolyl/benzothiazolyl/benzimidazolyl-pyrazoles were prepared from the synthetic intermediates (E)-N-(benzoxazol-2-yl)cinnamamide/(E)-N-(benzothiazol- 2-yl)cinnamamide/(E)-N-(1H-benzimidazol-2-yl)cinnamamides adopting simple and versatile synthetic methodologies. All the new compounds were tested for antioxidant activity. The compounds 5b, 8b and 14b displayed greater antioxidant activity when compared with the standard drug ascorbic acid. It was also observed that benzoxazolyl amido-linked derivatives displayed greater radical scavenging activity than the benzothiazolyl and benzimidazolyl amido-linked derivatives. Graphical Abstract: The amido-linked benzoxazolyl/benzothiazolyl/ benzimidazolyl-pyrroles and benzoxazolyl/benzothiazolyl/benzimidazolyl-pyrazoles were prepared from the synthetic intermediates (E)-N-(benzoxazol-2-yl) cinnamamide/(E)-N-(benzothiazol-2-yl)cinnamamide/(E)-N-(1H-benzimidazol-2-yl) cinnamamides adopting simple and versatile synthetic methodologies. All the new compounds were tested for antioxidant activity. The compounds 5b, 8b and 14b displayed greater antioxidant activity when compared with the standard drug Ascorbic acid. It was also observed that benzoxazolyl amido-linked derivatives displayed greater radical scavenging activity than the benzothiazolyl and benzimidazolyl amido-linked derivatives.[Figure not available: see fulltext.]

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem