Category: 4570-41-6

4570-41-6, Benzo[d]oxazol-2-amine is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

2-Bromopyridine (1) (lOg, 6.3mmol), benzo[d]oxazol-2-amine (2) (0.871g,6.4mmol), Xantphos (0.366g, 0.63mmol), and Cs2003 (3.09g, 9.4mmol) were combined in dry 1,4-dioxane (l5mL). The reaction mixture was degassed with N2(g) and placed under vacuum for 10mm. Pd2(dba)3 (0.289g, 0.31 mmol) was then added and the resulting reaction mixture was heated at 90¡ãC for 30h. It wasthen poured onto demineralized water (200mL), and extracted with EtOAc (3 x lOOmL). The organic phases were combined, dried over Na2SO4, filtered and subsequently evaporated under vacuum. The resulting residue was purified by flash chromatography, eluting with EtOAc/Hexane (1:1) to provide N-(pyridin-2- yl)benzo[d]oxazol-2-amine (3) as a yellow solid (0.8g, 60percent).LCMS (ES): Found 212.1 [MH]+.

4570-41-6, As the paragraph descriping shows that 4570-41-6 is playing an increasingly important role.

Reference£º
Patent; KARUS THERAPEUTICS LTD; SHUTTLEWORTH, Stephen Joseph; TOMASSI, Cyrille Davy; CECIL, Alexander Richard Liam; MACCORMICK, Somhairle; NODES, William John; SILVA, Franck Alexandre; WO2014/72714; (2014); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Benzo[d]oxazol-2-amine, cas is 4570-41-6, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,4570-41-6

Step 5:To a solution of (S)-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionic acid (214 mg, 0.67 mmol) and 2-amino-benzoxazole (90 mg, 0.67 mmol) in CH2Cl2 (10 mL) was added DMAP (24 mg, 0.2 mmol) and EDC.HCl (154 mg, 0.8 mmol).The reaction mixture was stirred at room temperature for 2 days.The reaction mixture was concentrated in vacuo.Purification by chromatography (silica, 0-1.5percent methanol/CH2Cl2 gradient), followed by RPHPLC purification (C4 reverse phase, 10-90percent acetonitrile/0.1percent aqueous TFA buffer) afforded (S)-N-Benzooxazol-2-yl-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionamide (68 mg, 23percent): m.p. 106-108¡ã C., LC/MS-ESI observed [M+H]+ 435, [alpha]28=+43.6¡ã (c=0.5, methanol), 75percent ee by chiral HPLC determination.

With the rapid development of chemical substances, we look forward to future research findings about Benzo[d]oxazol-2-amine

Reference£º
Patent; Brotherton-Pleiss, Christine E.; Walker, Keith A. M.; US2012/149718; (2012); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

4570-41-6,4570-41-6, Benzo[d]oxazol-2-amine is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Example 2N-Benzooxazol-2-yl-2-(4-methanesulfonyl-phenyl)-3-o-tolyl-propionamideTo a solution of 2-(4-methanesulfonylphenyl)-3-o-tolyl-propionic acid (prepared in example 1, 198 mg, 0.62 mmol) and 2-aminobenzoxazole (101 mg, 0.75 mmol) in CH2Cl2 (8 mL) was added DMAP (23 mg, 0.19 mmol) and EDC.HCl (144 mg, 0.75 mmol).The reaction mixture was stirred at room temperature overnight.Purification by chromatography (silica, 0.5-2.5percent methanol/CH2Cl2 gradient) afforded a white solid.The solid was taken up in CH2Cl2 and poured onto 0.1percent aqueous HCl and extracted 3 times with CH2Cl2 to remove the last trace of impurity.The organic layer was dried over Na2SO4 and concentrated in vacuo to afford N-benzooxazol-2-yl-2-(4-methanesulfonyl-phenyl)-3-tolylpropionamide (241 mg, 90percent) of a white solid: m.p. 105.7-108.9¡ã C., LC/MS-ESI observed [M+H]+ 435.

As the paragraph descriping shows that 4570-41-6 is playing an increasingly important role.

Reference£º
Patent; Brotherton-Pleiss, Christine E.; Walker, Keith A. M.; US2012/149718; (2012); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

As a common heterocyclic compound, it belongs to benzoxazole compound, name is Benzo[d]oxazol-2-amine, and cas is 4570-41-6, its synthesis route is as follows.,4570-41-6

1.34 g (10 mmol) benzo [d] oxazol-2-amine and3.07 g (10 mmol) of 1- (2,2-dibromovinyl) -2-nitrobenzene was dissolved in80 mL of dimethylformamide (DMF)Then stirred at a temperature of 120 ¡ã C for about 12 hours.The resulting reaction solution was cooled to room temperature.The organic layer was then extracted three times with 30 mL of water and 30 mL of ethyl acetate.The collected organic layer was dried with magnesium sulfate and the solvent was evaporated.The resulting residue was separated and purified by silica gel column chromatography, thereby completing the preparation of 1.87 g (75percent) of the intermediate I-1.

With the complex challenges of chemical substances, we look forward to future research findings about 4570-41-6,belong benzoxazole compound

Reference£º
Patent; Sanxing Display Co., Ltd.; Po Junhe; Jin Rongguo; Shen Wenji; Li Xiaorong; Zheng Enzai; Huang Xihuan; (110 pag.)CN107522719; (2017); A;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Name is Benzo[d]oxazol-2-amine, as a common heterocyclic compound, it belongs to benzoxazole compound, and cas is 4570-41-6, its synthesis route is as follows.,4570-41-6

General procedure: A 25 mL two-neck round-bottomed flask was charged with 2-aminobenzothiazole (1a, 180 mg,1.2 mmol), methyl acetoacetate (2a, 108 muL, 1.0 mmol), in 3 mL of CBrCl3/MeCN 1:9 (v/v) solvent mixture. KOt-Bu(224 mg, 2.0 mmol) was added slowly at room temperature and the reaction mixture was stirred under reflux for 16 h. Upon completion, the reaction mixture was diluted with 30 mL of ethyl acetate, filtered through a short pad of silica gel and washed down with an additional 60 mL ethyl acetate. The filtrate was washed with distilled water (3 ¡Á 30 mL) and the organic phase was dried with anhydrous Na2SO4. After filtration,the solvent was removed by rotary evaporation and the residue was purified by column chromatography using hexane and ethyl acetate (v/v = 8:1) as eluent to afford 3a with 84percentyield.

With the complex challenges of chemical substances, we look forward to future research findings about Benzo[d]oxazol-2-amine

Reference£º
Article; Roslan, Irwan Iskandar; Ng, Kian-Hong; Chuah, Gaik-Khuan; Jaenicke, Stephan; Beilstein Journal of Organic Chemistry; vol. 13; (2017); p. 2739 – 2750;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Name is Benzo[d]oxazol-2-amine, as a common heterocyclic compound, it belongs to benzoxazole compound, and cas is 4570-41-6, its synthesis route is as follows.,4570-41-6

Step 1:To a solution of 4-methylsulfonylphenylacetic acid (214 mg, 1 mmol) and 2-amino-benzoxazole (147 mg, 1.1 mmol) in CH2Cl2 (10 mL) was added DMAP (37 mg, 0.3 mmol) and EDC.HCl (230 mg, 1.2 mmol).The reaction mixture was stirred at room temperature for 6 h.The reaction mixture was concentrated in vacuo.Purification by chromatography (silica, 10-75percent ethyl acetate/hexanes gradient) afforded N-benzooxazol-2-yl-2-(4-methanesulfonyl-phenyl)acetamide (175 mg, 53percent): LC/MS-ESI observed [M+H]+ 331.

With the complex challenges of chemical substances, we look forward to future research findings about Benzo[d]oxazol-2-amine

Reference£º
Patent; Brotherton-Pleiss, Christine E.; Walker, Keith A. M.; US2012/149718; (2012); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Benzo[d]oxazol-2-amine, cas is 4570-41-6, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,4570-41-6

Example P (0342) 4-((Benzo[d]oxazol-2-yl(5-fluoropyridin-2-yl)amino)methyl)-N- (0343) 2-Bromo-5-fluoropyridine (1 ) (1.0g, 5.71 mmol), benzo[d]oxazol-2-amine (2) (766mg, 5.71 mmol), Xantphos (0.33g, 0.57mmol) and Cs2C03 (2.79g, 8.56mmol) were combined in dry 1 ,4-dioxane (15mL). The reaction mixture was degassed with N2(g) and placed under vacuum for 10min. Pd2(dba)3 (0.261 g, 0.28mmol) was then added and the resulting reaction mixture was heated at 90¡ãC for 30h. It was then poured onto demineralised water (200ml_) and extracted with EtOAc (3 x 100ml_). The organic phases were combined, dried over Na2S04, filtered and subsequently concentrated in vacuo. The resulting residue was purified by flash chromatography with EtOAc/Hexane (1 :1) to provide N-(5-fluoropyridin-2-yl)benzo[d]oxazol-2-amine (3) as a yellow solid (0.6g, 46percent). (0344) LCMS (ES): Found 230.1 [M+H]+.

4570-41-6 is used more and more widely, we look forward to future research findings about Benzo[d]oxazol-2-amine

Reference£º
Patent; KARUS THERAPEUTICS LTD; SHUTTLEWORTH, Stephen Joseph; WHALE, Andrew David; COLMAN, Lucy Mary; ROGERS, Helen Louise; (117 pag.)WO2017/208032; (2017); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

As a common heterocyclic compound, it belongs to benzoxazole compound, name is Benzo[d]oxazol-2-amine, and cas is 4570-41-6, its synthesis route is as follows.,4570-41-6

300 mg of (R)-tert-butyl 3-(4-amino-3-iodo-1H-pyrazolo[3,4-d]pyrimidin-1-yl)piperidine-1-carboxylate obtained in Synthetic Example 1 was dissolved in 3 mL of NMP. 118 mg of benzo[d]oxazol-2-amine, 20 mg of xantphos, and 0.15 mL of N-methylmorpholine were added thereto, and a degassing operation was carried out. Thereafter, 7.6 mg of palladium acetate was added thereto, and under a carbon monoxide atmosphere, the mixture was heated to 110¡ã C. and stirred for 2 hours. After the mixture was cooled, 4.5 mL of methanol and 0.45 mL of a 5 N aqueous solution of sodium hydroxide were added thereto, and the mixture was stirred for 30 minutes at room temperature. Thereafter, the pH was adjusted to 5.3 with 2 N hydrochloric acid, and a solid thus obtained was collected by filtration. The crude product was purified by a silica gel column (chloroform-methanol), and thus 257 mg of the title compound was obtained as a white solid. (0529) Physical property value: m/z [M+H]+ 479.3

With the complex challenges of chemical substances, we look forward to future research findings about 4570-41-6,belong benzoxazole compound

Reference£º
Patent; TAIHO PHARMACEUTICAL CO., LTD.; Hosoi, Fumihito; Nakachi, Yoshinori; Kajiwara, Daisuke; (63 pag.)US9782412; (2017); B2;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Benzo[d]oxazol-2-amine, cas is 4570-41-6, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,4570-41-6

Example 1 ethyl 6-hydroxy-4-oxo-1,2-dihydro-4H-pyrrolo [3,2,1-ij] quinoline-5-carboxylate (130 mg, 0.50 mmol) and benzo[d]oxazol-2-amine (80 mg, 0.60 mmol) is dissolved in DMF (2 mL) and placed in a sealed tube, heated at 160C for 30 minutes, Cooled slowly to room temperature. The resulting solid was filtered and washed with ethanol to give the target compound (KCNS-SM-31); 73 mg, 42% yield).

As the rapid development of chemical substances, we look forward to future research findings about 4570-41-6

Reference£º
Patent; Korea Research Institute of Chemical Technology; Park Cheol-min; Lee Seon-gyeong; Song Jong-hwan; (39 pag.)KR2019/67546; (2019); A;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO363,mainly used in chemical industry, its synthesis route is as follows.,4570-41-6

General procedure: A mixture of 6a/6b/6c/7a/7b/7c (1 mmol),benzoxazol-2-amine (2a)/benzothiazol-2-amine (2b)/1Hbenzimidazol-2-amine (2c)/(benzoxazol-2-yl)methanamine(3a)/(benzothiazol-2-yl) methanamine (3b)/(1H-benzimidazol-2-yl)methanamine (3c) (1.1 mmol), dry ethanol (4 ml)and a catalytic amount of methanesulfonic acid (0.2 ml) wasrefluxed for 6?7 h. The contents of the flask were cooledand diluted with water (15 ml). The separated solid wasfiltered, washed with water, dried and recrystallized from 2-propanol. N-(1,3-Benzoxazol-2-yl)-N?-[4-(1,3-benzoxazol-2-ylamino)-6-methyl-2-pyrimidinyl]sulfamide (9a)Red solid; yield (method A 65percent and method B 84percent); m.p.175?177 ¡ãC; IR (KBr) vmax 3367 (NH), 1583 (C=N), 1333(SO2), 1163 cm?1; 1H NMR (DMSO?d6, 400 MHz): delta =2.67 (s, 3H, CH3), 7.38 (s, 1H, C5?H), 7.47?7.69 (m, 8H,Ar?H), 8.45 (bs, 1H, NH?C2?), 8.63 (bs, 1H, NH?C2?), 8.70(bs, 1H, C2?NH); 13C NMR (DMSO?d6, 100MHz): delta =27.1 (CH3), 97.6 (C?5), 154.6 (C?2?), 161.3 (C?2?), 168.4(C?6), 171.3 (C?2), 172.3 (C?4), 113.3, 113.7, 122.6,122.9, 126.5, 126.8, 127.4, 127.9, 143.9, 144.4, 153.3, 153.8 (aromatic carbons); MS (m/z): 437.45 [M+]. Anal.Calcd. for C19H15N7O4S: C, 52.17; H, 3.46; N, 22.41.Found: C, 52.29; H, 3.50; N, 22.58.

With the synthetic route has been constantly updated, we look forward to future research findings about Benzo[d]oxazol-2-amine,belong benzoxazole compound

Reference£º
Article; Seenaiah, Dandu; Rekha, Tamatam; Padmaja, Adivireddy; Padmavathi, Venkatapuram; Medicinal Chemistry Research; vol. 26; 2; (2017); p. 431 – 441;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem