Simple exploration of Benzo[d]oxazol-2-amine

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Imidazo<2,1-b>benzothiazoles. 2. New Immunosuppressive Agents

A series of 2-phenylimidazo<2,1-b>benzothiazole derivatives was prepared and tested for immunological activities.Some of the compounds showed significant suppressive activity of delayed type hypersensitivity (DTH) without inhibition of humoral immunity in mice by oral administration.The most active compound was 2-(m-hydroxyphenyl)imidazo<2,1-b>benzothiazole (20).

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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BPNN-QSTR Modeling to Develop Isosteres as Sulfur-Free, Anti-Wear Lubricant Additives

The principle of isosterism was employed to design low- or zero-sulfur anti-wear lubricant additives. Thiobenzothiazole compounds and 2-benzothiazole-S-carboxylic acid esters were employed as templates. Sulfur in the thiazole ring or in the branched chain was exchanged with oxygen, CH2, or an NH group. Similarly, the template’s benzimidazole ring was replaced with a quinazolinone group. Quantitative structure tribo-ability relationship (QSTR) models by back propagation neural network (BPNN) method were used to study correlations between additive structures and their anti-wear performance. The features of rubbing pairs with different additives were identified by energy dispersive spectrometer-scanning electron microscope analysis. A wide range of samples showed that sulfur substitution in additive molecules was found to be reasonable and feasible. Combined effects of the anti-wear additive and the base oil were able to improve antiwear performance.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Some scientific research about Benzo[d]oxazol-2-amine

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AMIDO COMPOUNDS

Compounds of the formula 1: or pharmaceutically acceptable salts thereof, wherein the variables are as defined herein. Also disclosed are methods of making the compounds and using the compounds for treatment of diseases associated with the P2X7 purinergic receptor.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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Process for tetrazolyl-pyrimidinone derivatives

A process for preparing compounds of the formula STR1 wherein X is sulfur or oxygen; and R1 and R2 are independently selected from the group consisting of H and an alkyl group containing 1 to about 4 carbon atoms, or R1 and R2 are fused to form a benzene ring which is optionally substituted by one or more substituents independently selected from the group consisting of an alkyl group containing 1 to about 4 carbon atoms, an alkoxy group containing 1 to about 4 carbon atoms, and halogen. The process involves reacting together a 2-aminooxazole, 2-aminobenzoxazole, 2-aminothiazole or 2-aminobenzothiazole, an alkyl tetrazol-5-ylacetate, and a trialkyl orthoformate and cyclizing the resulting intermediate.

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Benzoxazole – Wikipedia,
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Isocyanide-based cascade reactions in the synthesis of aza-heterocycles: A marriage of convenience

Background: The design and performing of cascade reactions is a challenging but stimulating and interesting facet of organic synthesis, yet one that can convey conspicuous novelty, efficiency as well as elegance and sophistication to synthetic approaches. On the other hand, isocyanides are well-recognized as privileged synthons in the synthesis of a wide range of heterocycles. Objective: In this review, we try to illustrate the power, efficiency, and convenience of combining cascade process as an expedient strategy with versatility of isocyanide-based multicomponent reactions in the synthesis of aza-heterocycles from 1993 till date. Comprising isocyanides in cascade or sequential pathway also represents a milestone in combinatorial chemistry which is a bounce for this contented marriage.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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Synthesis and Antioxidant Activity of Amido-Linked Benzoxazolyl/Benzothiazolyl/Benzimidazolyl-Pyrazoles and Isoxazoles

A new class of amido-linked bis heterocycles-benzoxazolyl/benzothiazolyl/benzimidazolyl-pyrazoles and isoxazoles were prepared from benzoxazolyl /benzothiazolyl/benzimidazolyl-cinnamamides and tested for antioxidant activity.

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Synthesis and antimicrobial evaluation of N-(3-benzoxazol-2-yl-phenyl)-acrylamide

N-(3-benzoxazol-2-yl-phenyl)-acrylamide has been synthesized as an expected product by reacting 3-benzoxazol-2-yl-phenylamine (1) with chlo ropropioanyl chloride. The 3-benzoxazol-2-yl-phenylamine (1) was prepared according to reported methods through condensation reaction of 2-aminophenole with 3-aminobenzoic acid in presence of polyphosphoric acid (PPA). The acrylamide derivative 3 was scree ned for antimicrobial activity. The acrylamide 3 showed moderate inhibitory activity for both C. neoformans and leishmania species but the acrylamide 3 has no antibacterial activity. The course of the reaction was found to be of high yield (87%) and the title compound was spectroscopically confirmed and characterized by IR, 13C/1H-NMR, mass spectrometric techniques, and elemental analysis.

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Benzoxazole – Wikipedia,
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Diverse Oxidative C(sp2)-N Bond Cleavages of Aromatic Fused Imidazoles for Synthesis of alpha-Ketoamides and N-(pyridin-2-yl)arylamides

An efficient and chemoselective C(sp2)-N bond cleavage of aromatic imidazo[1,2-a]pyridine molecules is developed. A broad scope of amide compounds such as alpha-ketoamides and N-(pyridin-2-yl)arylamides are afforded as the final products in up to quantitative yields. Diverse C-N bond cleavages are controlled by the oxidative species used in this transformation, with various amide products afforded in a chemoselective fashion. A preliminary study indicated that some alpha-ketoamides exhibit anti-Tobacco Mosaic Virus activity for potential use in plant protection.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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1,2-DITHIOLANE COMPOUNDS USEFUL IN NEUROPROTECTION, AUTOIMMUNE AND CANCER DISEASES AND CONDITIONS

This invention provides confounds of the formula (I): wherein Y1, Y2 Z, X1, X2, and W are defined in the specification. These compounds are useful in the treatment of tyrosine kinases, MAPK signaling pathway kinases and Rho13K/AlphaKappaTau/mTor signaling pathway kinases-mediated diseases; or conditions, such as neurodegeneration, neuroprotection, cancer, autoimmune as well as other diseases and conditions associated with the modulation of tyrosine kinases selected from FYN, FYN Y531F, FLT3, FLT3 -ITD, BRK, ITK, FRK, BTK, BMX, SRC, FGR, YES1, LCK, HCK, RET, CSK, LYN, and ROSI; MAPK pathway kinases selected from ARAF, BRAE CRAP, ERK1 /2, MEK1, MEK2, MEK3, MEK4, MEK5. MEK6, and MEK7; and P13K/AKT/mTor pathway kinases: selected from mTor, P13K a, Rho13Kappa beta, P13Kgamma, and P13K delta.

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Benzoxazole – Wikipedia,
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Synthesis and Antimicrobial Activity of a New Class of Benzazolyl Pyrazoles

A new class of benzazolyl pyrazoles were prepared from the simple substrates benzoxazol-2-thiol, benzothiazol-2-thiol, 1H-benzimidazol-2-thiol and cinnamoyl chloride and tested for antimicrobial activity. The compounds 2-(benzothiazol-2-ylthio)-1-(3-(benzothiazol-2-ylthio)-5-phenyl-1H-pyrazol-1-yl)ethanone and 2-(benzothiazol-2-ylamino)-1-(3-(benzothiazol-2-ylthio)-5-phenyl-1H-pyrazol-1-yl)ethanone showed pronounced antibacterial activity against Klebsiella pneumoniae whereas 2-(1H-benzimidazol-2-ylthio)-1-(3-(1H-benzimidazol-2-ylthio)-5-phenyl-1H-pyrazol-1-yl)ethanone and 2-(1H-benzimidazol-2-ylamino)-1-(3-(1H-benzimidazol-2-ylthio)-5-phenyl-1H-pyrazol-1-yl) ethanone displayed excellent antifungal activity against Penicillium?chrysogenum.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem