483-76-1 | Heterocyclic Building Blocks-Benzoxazole

Tsao, Nai-Wen’s team published research in Journal of Wood Science in 2022-12-31 | CAS: 483-76-1

Composition analysis of exudates produced by conifers grown in Taiwan and their antifungal activity. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

1. Trivial name: delta-Cadinene.
2. It’s mainly derived from flue-cured tobacco, burley tobacco and flavoured tobacco, it has a strong aroma and a good fixing effect, suitable for perfume, cosmetics, can also be used in wine, cigarettes, and toothpaste.
. Recommended Products is: 29350-73-0 and 51905-84-1.

Exudates are involved in the defense mechanism of trees; they could work against insects or microorganisms through a phys. or chem. system. The main components of exudates are terpenoids. This study identified the main compounds of exudates from 13 conifers of Taiwan using gas chromatogram-mass spectrometry (GC-MS) and spectroscopic anal. The results revealed that the main volatiles were ¦Á-pinene, ¦Â-ocimene, ¦Â-pinene, sabinene, and caryophyllene. On the other hand, the main nonvolatile compounds were diterpenoids, which were classified into three skeletons (abietane-, labdane-, and pimarane-types). Among these, abietane-type presented in Pinaceae and in most of Cupressaceae; labdane-type presented in Pinaceae and in all of Cupressaceae and Araucariaceae; pimarane-type existed in both Pinaceae and Cupressaceae. Furthermore, the epigenetics of conifers anal. results by GC-MS and heteronuclear single quantum coherence (HSQC) of NMR (NMR) fingerprints were similar to traditional taxonomy classification; it indicated that exudates chemotaxonomy by using GC-MS and HSQC profiling is a useful technol. to classify the conifers. Besides, the exudates of Pinus elliottii, Pinus taiwanensis, Calocedrus macrolepis and Chamaecyparis formosensis possessed the strong antifungal activity. For white-rot fungus, Trametes versicolor, Pinus morrisonicola, Chamaecyparis obtusa, and Araucaria heterophylla exhibited the higher antifungal index. For brown-rot fungus, Laetiporus sulfureus, Pinus elliottii, Pinus morrisonicola, and Chamaecyparis formosensis revealed a good antifungal activity.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

He, Li-Li’s team published research in Scientia Horticulturae (Amsterdam, Netherlands) in 2023-01-27 | CAS: 483-76-1

In vitro and in vivo antifungal activity of Cymbopogon citrates essential oils from different climate conditions against Botrytis cinerea. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Essential oils (EOs) are natural, volatile and aromatic substances extracted from some specific plants. EOs are the secondary metabolite of plants and usually varies with different plants and climate conditions, even in the same plant species but different climate conditions. The antifungal properties of EOs from medicinal as well as other edible plants have been recognized for very long time. Cymbopogon citratus oil, which is used as a food flavoring agent, possesses a broad spectrum of in vitro antifungal activities attributed to the high content of monoterpenoids such as ¦Á-Citral and ¦Â-Citral. In this study we focused on the changes of components of EOs in C. citratus growing in different climate conditions and their antifungal activities as well. The samples of C. citrates, fresh and dried, obtained from five different climate conditions in Southern and Southwestern China (Kunming, Jinghong, Fangchenggang, Zengcheng, Yuxi). The C. citrates EOs were extracted by the steam distillation method and analyzed by gas chromatog. coupled with mass spectrometry (GC-MS) and gas chromatog.-flame ionization detection (GC-FID). The results showed that the content of ¦Á-Citral was the highest in ten EOs. Fresh and dried C. citratus EOs accounted for 38.7% and 43.3% in Zengcheng, resp. However, fresh and dried C. citratus EOs accounted for 24.2% and 23.1% in Kunming. The effects of C. citratus EOs from different climate conditions against Botrytis cinerea were studied. All EOs had good inhibition against mycelial growth and spore germination of B. cinerea in vitro. At 15.63 mg/L, the inhibition of mycelial growth with the dried C. citrates EO from Zengcheng was significantly greater than that with the other EOs, with an inhibitory effect of 96.3%. It completely inhibited the mycelial growth of B. cinerea at 31.25 mg/L. Ten EOs also had good inhibitory effects on the rotten area of cherry tomatoes infected by B. cinerea in vivo. At 125 mg/L, the decay area of cherry tomatoes was reduced by more than 90%. The results indicated that the constituents in EOs of C. citrates are different from one growing place to another. The EOs of C. citrates may be considered as potential candidates to protect postharvest fruit from B. cinerea damage.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Luz, Tassio Romulo Silva Araujo’s team published research in Experimental Parasitology in 2022-12-31 | CAS: 483-76-1

Seasonal variation in the chemical composition and larvicidal activity against Aedes aegypti L. of essential oils from Brazilian Amazon. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Arthropod-borne viral diseases are important public health threats in tropical countries. In the Americas, diseases such as Dengue, Zika, Chikungunya, Mayaro, and Yellow fever, which are mainly transmitted by Aedes aegypti L. are responsible for high rates of morbidity and mortality in the populations. The incidence of those viruses has increased in the last few years, due to the decrease of vector control programs, as well as, the resistance of this vector in front of many products that have been used in this proposal. Plant-based products such as essential oils are a promising alternative for Ae. aegypti control. In this context, the present work aims to investigate the seasonality effect on the larvicidal potential and safety of essential oils from 4 endemic plants of the Brazilian Amazon, as well as to verify their larvicidal activity and safety. The species were collected in the rainy and dry periods (Eugenia uniflora L., Lantana camara L., Ocimum basilicum L., Plectranthus neochilus Schlrt.). The essential oils were extracted by hydrodistillation and chem. composition was determined by gas chromatog. coupled to mass spectrometry. The larvicidal activity was performed according to the methodol. recommended by the World Health Organization. The safety of the oil use was evaluated against two non-target organisms: Artemia salina Leach and Danio rerio Hamilton Buchanan. Essential oils of E. uniflora, L. camara, O. basilicum, P. neochilus, presented as major compounds, in both collection periods, the substances Curzerene, Germacrene D, Me chavicol and, Caryophyllene, resp. However, showed a qual. and quant. variation of this composition All oils showed promising results against Ae. aegypti larvae with LC50 between 41.7 and 275.8 ¦Ìg/mL. They were efficient against Ae. aegypti but showed high toxicity to non-target organisms, requiring addnl. safety studies. Despite these results showing that those essential oils are not ideal larvicides because they presented toxicity to non-target organisms, bioprospection is a promising tool to help reduce the dissemination of arboviruses, and they can use in artificial breeders of Ae. aegypti larvae, where water will not be reused for human consumption or have other cohabiting organisms.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Thinh, B. B.’s team published research in Chemistry of Natural Compounds in 2022-07-31 | CAS: 483-76-1

Chemical composition and antioxidant activity of essential oil from fruit of Schisandra perulata. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Schisandra (Schisandraceae) grow in East Asia and number 30 species. They are rich sources of lignans and triterpenoids that are known to activate various useful biol. process. S. perulata Gagnep. is an endemic species of the genus Schisandra found in Vietnam. We analyzed the composition and antioxidant activity of essential oil obtained from fruit of S. perulata. Essential oils were collected,dried over anhydrous Na2SO4, and stored at 4¡ãC for further anal. Each extraction was performed in triplicate. The chem. compositions of essential oils from fruit of S. perulata were determined by gas chromatog. (GC)and GC-mass-spectrometry (GC-MS) using the published method . Anal. of GC-MS spectra of the essential oil detected 46 compounds making up 90.25% of the oil (Table 1). The essential oil was dominated by sesquiterpenes (76.90%). Oxygen-saturated sesquiterpenes, monoterpenes, and oxygen-saturated monoterpenes made up 4.94, 4.86, and 3.55%,resp. The main oil constituents were ¦Ä-cadinene (24.74%), ¦Á-ylangene (16.38), trans-¦Á-bergamotene (7.84), ¦Â-elemene(6.91), and ¦Â-himachalene (6.27). This is the first report on the chem. composition of essential oil from fruit of S. perulata.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Chen, Wei’s team published research in Food Control in 2022-10-31 | CAS: 483-76-1

Understanding the aroma diversity of Dancong tea (Camellia sinensis) from the floral and honey odors: Relationship between volatile compounds and sensory characteristics by chemometrics. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Dancong is a Chinese oolong tea famous for its aroma diversity. However, this diversity in characteristic is challenging to be clarified in either sensory or chem. aspects. In this study, the aromas from Dancong teas were characterized based on the typical odors of “”floral”” and “”honey””. The volatile compounds underlying the odors were investigated through chemometrics. Seventy Dancong teas of various categories were collected to approx. the diversity in aroma. According to the sensory evaluation, the floral or honey odor was detected in every sample. For volatile characterization, 57 compounds were identified by gas chromatog.-mass spectrometry (GC-MS) coupled with headspace-solid phase microextraction (HS-SPME) across samples. The difference in floral and honey odors was related to volatile variation among the teas, as both the odor-based classification and the volatile-based unsupervised learning analyses yielded consistent sample clustering patterns. Nine volatiles were identified as putative markers for the odor difference, where indole, (E)-nerolidol, 2-phenylacetonitrile, and ¦Ã-caprolactone accounted for the floral odor predominance, while hexyl 2-methylbutanoate, (Z)-3-hexenyl pentanoate, (Z)-linalool oxide (pyranoid), (E)-linalool oxide (furanoid), and (Z)-linalool oxide (furanoid) contributed to the honey odor perception. These results point to a volatile-endorsed categorization framework based on the floral and honey odors that can assist in Dancong aroma quality control.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Bisht, Manisha’s team published research in Chemistry of Natural Compounds in 2022-09-30 | CAS: 483-76-1

Composition of Essential Oil from the Aerial Part of Aster peduncularis. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

This article illustrates identification of composition of essential oil from Aster peduncularis. The aerial parts of A. peduncularis were collected from Berinag in the district of Pithoragarh, Uttarakhand, India, in August 2019, at the flowering stage. Essential oil was obtained from ground aerial parts of the plant by hydrodistillation for 5 h using a Clevenger-type apparatus and analyzed by GC and GC-MS. GC and GC-MS anal. of the essential oil showed the presence of 28 components representing 92.6% of the total oil composition The oil was found to be rich in monoterpene hydrocarbons (59.5%), oxygenated sesquiterpenes (17%) and sesquiterpene hydrocarbons (13.5%).

Composition of Essential Oil from the Aerial Part of Aster peduncularis. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Mattar, Valeria Tapia’s team published research in Pesticide Biochemistry and Physiology in 2022-07-31 | CAS: 483-76-1

Insecticidal activity of the essential oil of Schinus areira against Rhipibruchus picturatus (F.) (Coleoptera: Bruchinae), and its inhibitory effects on acetylcholinesterase. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

During the storage of Prosopis alba pods, substantial quant. and qual. losses were observed One of the main factors is the seed beetle Rhipibruchus picturatus. A key strategy to develop new pest control management is the use of essential oils (EOs) due they are efficient, less toxic, and less persistent in the environment compared to synthetic pesticides. In this context, seeds and leaves of Schinus areira L. (Anacardiaceae) EOs and Citrus spp. EO were studied in the present work. In the leaves of S. areira EO, 1-epi-cadinol, sesquiterpenoid alc., was the major compound On the other hand, the main compounds of the EO extracted from S. areira seeds are the monoterpenes sabinene, and ¦Á-pinene. Finally, in the Citrus EO, limonene is the principal component. The three EOs obtained exhibited insecticidal activity against R. picturatus, being the first report of the use of EOs against this insect pest. The best insecticidal results were obtained with the leaves of S. areira EO. Moreover, this EO inhibits the acetylcholinesterase enzyme in vitro assays. Mol. docking studies on acetylcholinesterase (AChE) suggest that the main components of the leaves of S, areira EOs, bind to the active site of the enzyme, in good agreement with in vitro competitive inhibition against AChE observed for this EO. The data obtained demonstrate the potential use of Schinus areira EOs in the development of new storage pest control strategies.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Shahhoseini, Reza’s team published research in Biochemical Systematics and Ecology in 2022-10-31 | CAS: 483-76-1

Evaluation of phytochemical profiles and relationships of compounds in Lippia citriodora during multiple growth-exploitation phases. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

In the present study the variations of biomass, essential oil content and composition of lemon verbena (Lippia citriodora) during different growth-exploitation phases from 27th May 2020 to 8th June 2021 were investigated. The uniform rooted cuttings were planted in the greenhouse under natural light. The aerial parts of lemon verbena at flowering stage were harvested at six times included 27th May (H1), 29th August (H2), 4th Nov. (H3), 17th Jan. (H4), 27th March (H5), and 8th June (H6). Hydro distillated essential oils were analyzed by using GC-FID and GC/MS techniques to determine the essential oil profile. Results showed a considerable variation in plant biomass, essential oil quantity and quality at different harvesting times. Plant biomass increased by 66.83% up to fourth harvesting time (H4) then decreased. During the studied harvesting frequencies the essential oil content of L. citriodora showed a sinusoidal trend. The highest essential oil content (0.858% v/w) and yield (17.95 L ha-1) were obtained at third harvesting time (H3) and in the followed harvesting times their contents were decreased. The observed changes in the essential oil composition of L. citriodora during different harvesting times were due to the relative proportions of constituents and the presence of new constituents. In the all essential oil samples, oxygenated monoterpenes represented by geranial (25.42-30.11%) and neral (19.81-24.19%) were the predominant compounds The highest ratio of monoterpenes to sesquiterpenes compounds (¡Ö5:1) was recorded in collected plants at third harvesting time.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Shi, Yali’s team published research in Food Chemistry in 2022-11-15 | CAS: 483-76-1

Comprehensive investigation on non-volatile and volatile metabolites in four types of green teas obtained from the same tea cultivar of Longjing 43 (Camellia sinensis var. sinensis) using the widely targeted metabolomics. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

In this study, we produced roasted, baked, steamed, and sun-dried green tea products using the same batch of fresh tea leaves (FTL) of Longjing 43 (Camellia sinensis var. sinensis), and explored processing effects on the metabolic profiles of four types of green teas (FGTs) using the widely targeted metabolomics. Results showed that 146 differential metabolites including flavonoids, amino acids, lipids, and phenolic acids were screened among 1034 non-volatiles. In addition, nineteen differential metabolites were screened among 79 volatiles. Most of non-volatiles and volatiles metabolites changed notably in different manufacturing processes, whereas there were no significant differences (p>0.05) in the levels of total catechins between FGTs and FTL. The transformation of metabolites was the dominant trend during green tea processing. The results contribute to a better understanding of how the manufacturing process influences green tea quality, and provide useful information for the enrichment of tea biochem. theory.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Pham, Ty Viet’s team published research in Natural Product Communications in 2022-09-30 | CAS: 483-76-1

Volatile Constituents and Anti-Osteoporotic Activity of the n-Hexane Extract From Homalomena gigantea Rhizome. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

This study analyzed the chem. composition and anti-osteoporosis activity of the n-hexane extract of Homalomena gigantea rhizome. Sixty compounds, representing 92.0% of the extract, were identified by gas chromatog.-mass spectrometry. Linalool (15.3%), oplopanone (9.8%), (¦¥)-¦Á-atlantone (5.6%), khusinol acetate (5.4%), bullatantriol (4.3%), and ¦Â-sitosterol (3.8%) were the main constituents. The anti-osteoporotic activity of the n-hexane extract was determined by measuring alk. phosphatase (ALP) activity, collagen content, and the mineralization of MC3T3-E1 cells. At concentrations of 4.0 and 20.0 ¦Ìg/mL, the n-hexane extract increased ALP activity by 8.2% and 23.7%, and increased collagen secretion by MC3T3-E1 cells by 114.9% and 112.4%, resp. At 4 ¦Ìg/mL, the extract significantly promoted the mineralization of MC3T3-E1 cells by as much as 133.2% compared to the neg. control. These results suggested that H. gigantea rhizome contains a natural anti-osteoporotic compound

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem