483-76-1 | Page 10 of 10 | Heterocyclic Building Blocks-Benzoxazole

Toplan, Gizem Gulsoy’s team published research in South African Journal of Botany in 2022-07-31 | CAS: 483-76-1

Phytochemical screening and biological evaluation of Salvia hydrangea Dc. ex Benth. growing in eastern Anatolia. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

1. Trivial name: delta-Cadinene.
2. It’s mainly derived from flue-cured tobacco, burley tobacco and flavoured tobacco, it has a strong aroma and a good fixing effect, suitable for perfume, cosmetics, can also be used in wine, cigarettes, and toothpaste.
. Recommended Products is: 29350-73-0 and 51905-84-1.

Salvia species have lately gained significant interest as a result of their suitable utilization in various industries. In the current study, S. hydrangea, one of the most consumed sages in the eastern region of Turkey, has been evaluated for phytochem. composition as well as in vitro pharmacol. potential comparatively for the first time. The phytochem. composition of S.hydrangea was investigated by LC-MS/MS, GC-FID, and GC/MS. To reveal its biol. activities, antioxidant, antimicrobial, and also acetylcholinesterase activities of different solvent extracts such as water, n-hexane, chloroform, and methanol were determined According to GC/MS anal., the primary components of the oil were identified as camphor (46.0%), 1,8-cineole (7.5%), camphene (6.8%), limonene (6.5%), a-pinene (5.6%) and b-pinene (6.1%). Addnl., in the infusion and methanol extract, rosmarinic acid and luteolin glycoside were detected as predominant phenolics by LC-MS/MS. In DPPH¡¤, CUPRAC, and FRAP test results of the samples indicated strong to moderate antioxidant ability in all samples studied, addnl., among them, the infusion exhibited significant acetylcholine inhibition properties comparable with galanthamine. With regard to antimicrobial activity, all of the tested microorganisms had MIC values ranging from 15 to 2000¦Ìg/mL. Based on these findings, S. hydrangea may have promising properties for a variety of industrial applications in the pharmaceutical, food, and cosmetic industries.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Soares, Krissie D.’s team published research in Journal of Ethnopharmacology in 2022-10-28 | CAS: 483-76-1

Chemical composition and anti-inflammatory activity of the essential oils of Piper gaudichaudianum and Piper mikanianum. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Inflammation is the bodys normal protective response to injury and is stimulated by pathogens, toxic compounds, damaged cells or radiation, promoting healing and restoring homeostasis to the injured tissue. Leaves of Piper gaudichaudianum Kunth, known as “”pariparoba”” are widely used in folk medicine for the relief of toothache, while the fresh roots are used as anti-inflammatory and to treat liver disorders. For P. mikanianum (Kunth) Steud is known as “”aguaxima””, is widely used in the treatment of inflammation, rheumatism and ulcer, with its roots being used for stomach disorders and as a diaphoretic in intermittent fevers. Therefore, this work aims to chem. characterize the essential oil of Piper gaudichaudianum and Piper mikanianum, as well as the evaluation of neutrophil antichemotactic activity of both essential oils in order to complement the information of its traditional use, taking the leaves as plant material and, with that, corroborating its use in folk medicine for the treatment of inflammatory diseases. The essential oil from leaves of both Piper species were obtained from crushed fresh samples, by hydrodistillation using a Clevenger type-apparatus for 4 h. The yield determination was performed as vol/wt (v/w) and in triplicate. The amount of essential oil obtained was quantified in mL. The identification and quantification of the compounds was performed using gas chromatog.-mass spectrometry (GC-MS) and gas chromatog.-flame ionization detection (GC-FID). The in vitro anti-inflammatory activity was evaluated using the model of modified Boyden chamber. In this test the essential oils were tested for their ability to inhibit leukocyte chemotaxis stimulated by Escherichia coli lipopolysaccharide. The chem. composition of the essential oils revealed the identification of 26 constituents for P. gaudichaudianum being the sesquiterpenes ¦Â-selinene (14.0%) and viridiflorene (10.5%) the main compounds, followed by caryophyllene oxide (9.3%) and (E)-nerolidol (9.0%). For P. mikanianum essential oil, ¦Â-myrcene (17.2%) and bicyclogermacrene (26.3%) were the major components in the monoterpenes and sesquiterpene fractions, resp. The essential oils were also tested for their ability to inhibit neutrophil chemotaxis in vitro when stimulated by Escherichia coli lipopolysaccharide. Both essential oils showed antichemotactic effect with reduction in migration of 0-72.2% for P. gaudichaudianum and 8.6-100% for P. mikanianum to same concentrations, suggesting a response to acute inflammatory processes. Since up to date there is no report of this biol. activities by this mechanism (antichemotactic assay) for essential oils this species. These results showed that the essential oils of P. gaudichaudianum and P. mikanianum have a great capacity to inhibit neutrophil chemotaxis in an inflammatory process, in a dose-dependent way, suggesting anti-inflammatory potential, by preventing its accumulation at the injury site with the possibility of tissue damage. Findings of these studies support the traditional use of these species in the treatment of inflammatory processes.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Hsu, Kuang-Ping’s team published research in Natural Product Communications in 2022-07-31 | CAS: 483-76-1

Chemical Compositions and Anti-Mildew Effects of Cinnamomum micranthum Leaf and Twig Essential Oils on Paper. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

In this study, we evaluated the anti-mildew effects of paper treated with essential oils of leaves, twigs, and their main constituents from Cinnamomum micranthum. The main ingredients with the greater anti-mildew effects on paper capability were also purified and identified. Fresh leaves and twigs of C. micranthum were hydrodistillated in a Clevenger-type apparatus, and the resulting oil characterized using GC-FID and GC-MS instruments. The leaf essential oil consisted principally of n-decanal (50.1%), (E)-beta-ocimene (7.9%), (E)-nerolidol (6.5%), and (E)-beta-caryophyllene (3.8%), and the twig oil¡äs main components were tau-cadinol (18.3%), (E)-beta-ocimene (16.4%), alpha-cadinol (13.6%), n-decanal (10.6%), and beta-selinene (5.8%). Comparing the mildew resistance of the oils on paper exhibited that twig oil was the best anti-mildew activity; at 200 ¦Ìg/cm2, the twig oil completely inhibited the growth of Aspergillus clavatus, Cladosporium cladosporioides, Chaetonium globosum, Myrothecium verrucaria, and Penicillium citrinum. The twig oil was further divided into 8 fractions (TO1-TO8). TO4 fraction had moderate anti-mildew effects; at the concentration of 200 ¦Ìg/cm2, all fungi strains were totally inhibited, except A niger, and Trichoderma viride, which were 83.5%, and 93.2% inhibited, resp. The main ingredients of TO4 fraction were tau-cadinol, and alpha-cadinol, so we isolated and used the for anti-mildew effect tests; tau-cadinol, and alpha-cadinol showed moderate anti-mildew activities. Since C. micranthum twig essential oil, tau-cadinol, and alpha-cadinol were exhibited a great anti-mildew effects on paper, they are worth further investigations and utilization.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

de Souza, Diego Pereira’s team published research in Industrial Crops and Products in 2022-10-15 | CAS: 483-76-1

Untargeted metabolomics used to describe the chemical composition and antimicrobial effects of the essential oil from the leaves of Guatteria citriodora Ducke. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Plant oils are sources of metabolites that have enormous potential for industrial applications. Herein, the chem. profile and in vitro antimicrobial activity of the essential oil (EO) from the leaves of Guatteria citriodora Ducke (Annonaceae) have been investigated for the first time. The composition of the hydrodistd. EO was analyzed using gas chromatog.-mass spectrometry (GC-MS), which permitted the identification of oxygenated monoterpenes as the most highly representative class, and included citronellal (40.99%) and citronellol (14.6%) as the main compounds The antimicrobial activity of G. citriodora EO (GcEO) was evaluated against pathogenic bacteria and phytopathogenic fungi. The exptl. design was completely randomized (CRD), and used doses for each microorganism. Gram-pos. strains were the most sensitive with a min. inhibitory concentration (MIC) of 5.0¦ÌL mL-1, while Gram-neg. strains were 10.0¦ÌL mL-1. The most potent antifungal activity was against Alternaria alternata (MIC of 1.25¦ÌL mL-1). In addition, it fully inhibited A. alternata conidia germination at the min. inhibitory concentration The nucleic acid and soluble protein contents were significantly released from the conidia of A. alternata after treatment with GcEO. Using SEM (SEM), morphol. alterations were observed in the conidia, which indicates that a lesion in the cytoplasmic membrane is one of its mechanisms of action. Overall, these results indicate that GcEO is an antimicrobial agent with potential applications in the agriculture, food, and pharmaceutical industries.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Ren, Guilin’s team published research in Scientific Reports in 2022-12-31 | CAS: 483-76-1

Study of the volatilization rules of volatile oil and the sustained-release effect of volatile oil solidified by porous starch. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Volatile oil from traditional Chinese medicine has various biol. activities and has pharmacol. activities in the central nervous system, digestive system, cardiovascular system, respiratory system, etc. These oils are widely used in clin. practice. However, the development of their clin. applications is restricted due to the disadvantages of volatile oils, such as high stimulation, high volatility and poor stability. To improve the stability of a volatile oil in the preparation process, its volatilization and stable release must be controlled. In this paper, porous starch was used as a solid carrier material, and liquid volatile oil was solidified by phys. adsorption. GC-MS was used to determine the chem. constituents of the volatile oil, solidified powder and tablets, and the volatilization rules of 34 chem. constituents were analyzed statistically. The solidified volatile oil/porous starch powder was characterized by XRD, TGA and DSC, and the VOCs of the volatile oil before and after solidification were analyzed by portable GC-MS. Finally, the stable release of the volatile oil could be optimized by changing the porous starch ratio in the formulation. Volatilization was shown to be closely related to the peak retention time and chem. composition, which was consistent with the theory of flavor. The phys. properties and chem. composition of the volatile oil did not change after curing, indicating that the adsorption of the volatile oil by porous starch was phys. adsorption. In this paper, the porous starch-solidified volatile oil had a slow-release effect, and the production process is simple, easy to operate, and has high application value.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Askarova, O. K.’s team published research in Chemistry of Natural Compounds in 2022-09-30 | CAS: 483-76-1

Chemical Composition and Antimicrobial Activity of Essential Oil from the Aerial Part of Haplophyllum latifolium. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

A total of 26 constituents were identified in essential oil from the aerial part. It was found that Haplophyllum latifolium essential oil was a rich source of terpenes. Its composition was dominated by monoterpene (46.1%) and sesquiterpene hydrocarbons (35.5%). The content of oxidized monoterpenes and sesquiterpenes in the essential oil made up on 8.2 and 1.3%, resp. The major constituents of the essential oil were germacrene B (24.7%), limonene (18.2%), ¦Á-phellandrene (14.7%), 3-methyl-2-butenal (6.2%), ¦Â-phellandrene (5.0%), ¦Â-caryophyllene (4.3%), terpinolene (3.9%), ¦Ã-elemene (3.2%), and linalyl acetate (2.6%). The essential oil could be of interest to the perfume and cosmetic industries because of the high content of volatile terpenes and pleasant aroma. Results of the antimicrobial tests showed that S. aureus, B. subtilis, E. coli, and C. albicans were sensitive to the effects of H. latifolium essential oil. The greatest antibacterial effect was found against S. aureus with an inhibition zone diameter of 12.08 ¡À 0.12 mm.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Costa, Wendeo Kennedy’s team published research in Chemistry & Biodiversity in 2022-09-30 | CAS: 483-76-1

Influence of Seasonal Variation on the Chemical Composition and Biological Activities of Essential Oil from Eugenia pohliana DC Leaves. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

The purpose of this study was to analyses the influence of seasonal variation on the chem. composition and antimicrobial, antioxidant and cytotoxicity activities of the essential oil (EO) extracted from the leaves of Eugenia pohliana. Chem. characterization of the samples – by gas chromatog.-mass spectrometry – found 35 and 38 components for summer and winter, resp., of the EO from E. pohliana leaves, totaling 47 different compounds Anal. of antioxidant capacity (DPPH, ABTS and TAC) revealed that the summer EO showed greater free radical scavenging capacity than the winter. Similarly, the summer EO exhibited superior antimicrobial potential (MIC=128-512 ¦Ìg/mL and MMC=128-1024 ¦Ìg/mL, compared to the winter EO (128-2048 ¦Ìg/mL and 256-2048 ¦Ìg/mL, resp.). Results showed that both oils had a low potential to cause hemolysis. This study provides new scientific evidence on the influence of seasonality on the pharmacol. properties of E. pohliana leaves and its potential for the development of herbal medicines.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Naim, Nadia’s team published research in Vibrational Spectroscopy in 2022-11-30 | CAS: 483-76-1

ATR-FTIR spectroscopy combined with DNA barcoding and GC-MS to assess the quality and purity of saffron (Crocus sativus L.). Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Fourier transform IR spectra of saffron (Crocus sativus L.) samples were acquired using attenuated total reflectance (ATR-FTIR). The main objective of the study was to determine the chem. composition of 11 samples of saffron collected from different areas in Morocco using the chemometric anal. of ATR-FTIR fingerprints and identifying the adulterated saffron among samples bought from local markets in different countries (Spain, Iran, and Morocco). The the authenticity and the purity of saffron samples was validated through a mol. anal. (DNA barcoding coupled to sequencing) and chromatog. anal. GC-MS. The results of ATR-FTIR showed vibration intensities of six distinct fingerprint regions displaying statistically significant differences. The spectrum of the sample from Timjicht (Taznakht) showed typical bands due to the vibration in 3000-2800 cm-1 (the richest in carbohydrates, lipids, and amino acids) and 1800-1725 cm-1 region (the richest in carbonyl and ester groups) and was classified a single subset in samples scatter plot. Then samples from Boulmane (S2), Ain Leuh (S3), Taliouine (S6), and Taznakht (S7-S8) were classified close to each other, which indicates the similarity in their vibration intensities mainly in the region of carbohydrates, lipids, amino acids, and esters. Similarities in terms of proteins and hydroxyl groups were revealed between the samples from El Mers (S11) and Taliouine (S1). Finally, the last sub-group contained samples from Ourika, Azilal and Ain Atia, which showed low composition in all components. Furthermore, to detect adulterated saffron from samples of unknown origin, a comparison of the ATR-FTIR spectra were carried out with spectra of pure saffron and results showed that the peaks at 1706, 1732, and 1225 cm-1 (linked to crocin which are present primarily in saffron) were absent in one sample (SI). Interestingly, the use of another plant species named Arrhenatherum elatius as materiel for saffron adulteration was confirmed by the mol. study (DNA barcoding) and chromatog. anal. GC-MS.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Shuai, Mengying’s team published research in Journal of Chromatography A in 2022-08-02 | CAS: 483-76-1

Geographical origin of American ginseng (Panax quinquefolius L.) based on chemical composition combined with chemometric. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

American ginseng (Panax quinquefolius L.) is protected by Geog. Indications as harvested roots have different regional characteristics. The aim of this study was to distinguish 95 American ginseng samples from four origins (including America, Canada, Shandong province and the Northeast provinces in China), and to further discriminate samples harvested within the protected designation of origin (PDO) from those harvested in non-PDO regions. Two metabolomic methods were used to acquire qual. data on the metabolites of American ginseng samples from different origins, namely high-performance liquid chromatog. (HPLC) and headspace-gas chromatog.-mass spectrometry (HS-GC-MS). There were significant differences in numerous metabolites, including volatile compounds and ginsenosides. American ginsengs from four different regions were discriminated based on 25 volatile compounds and 8 ginsenosides using linear discriminant anal. (LDA), which had a 96.8% accuracy and a 74.7% cross validation rate, and random forest (RF) modeling, which reached 100% accuracy using the training set and 92.9% accuracy using the testing set. The same 33 analytes combined with LDA and RF were compared for discrimination of PDO and non-PDO samples. The 100% accuracy was again obtained using the RF model, but only when using data from both HS-GC-MS and HPLC. The result showed that chem. composition combined with chemometric is effectively and accurately to study the origins of American ginseng.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Mahmoud, Mona F.’s team published research in Biomedicine & Pharmacotherapy in 2022-09-30 | CAS: 483-76-1

Black pepper oil (Piper nigrum L.) mitigates dexamethasone induced pancreatic damage via modulation of oxidative and nitrosative stress. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Dexamethasone acts as an immunosuppressive drug and has been used recently in the management of specific coronavirus disease 2019 (COVID-19) cases; however, various adverse effects could limit its use. In this work, we studied the mitigation effects of black pepper oil (BP oil) on glycemic parameters, dyslipidemia, oxidative and nitrosative stress and pancreatic fibrosis in dexamethasone-treated rats. Animals were divided into five groups that were treated with vehicle, dexamethasone (10 mg/kg, SC) or black pepper oil (BP oil, 0.5 mL, or 1 mL/kg) or metformin (50 mg/kg) plus dexamethasone for 4 consecutive days. Serum insulin, blood glucose, total cholesterol, triglycerides, and Homeostatic Model Assessment for Insulin Resistance (HOMA-IR) were higher in the dexamethasone group vs the control group and decreased in BP oil and metformin groups relative to the dexamethasone group. Pancreatic nitric oxide, inducible nitric oxide synthase and malondialdehyde levels were increased in the dexamethasone group vs the control group and decreased in BP oil and metformin groups relative to the dexamethasone group. Pancreatic endothelial nitric oxide synthase and reduced glutathione were declined in the dexamethasone group vs the control group. They were increased in BP oil and metformin groups relative to the dexamethasone group. Moreover, the pancreatic islets diameter and collagen deposition were assessed and found to be higher in the dexamethasone group vs the control group. BP oil and metformin groups showed to regress this effect. In conclusion, BP oil may alleviate hyperglycemia, hyperinsulinemia, insulin resistance, dyslipidemia and pancreatic structural derangements and fibrosis by suppressing oxidative stress, increasing endogenous antioxidant levels, modulating nitric oxide signaling, preventing pancreatic stellate cells transition and collagen deposition.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem