483-76-1 | Page 3 of 10 | Heterocyclic Building Blocks-Benzoxazole

Lin, Chun-Ya’s team published research in Biochemical Systematics and Ecology in 2022-12-31 | CAS: 483-76-1

Chemotaxonomic identification of Chamaecyparis formosensis Matsumura and Chamaecyparis obtusa var. formosana (Hayata) Rehder using characteristic compounds of wood essential oils. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

1. Trivial name: delta-Cadinene.
2. It’s mainly derived from flue-cured tobacco, burley tobacco and flavoured tobacco, it has a strong aroma and a good fixing effect, suitable for perfume, cosmetics, can also be used in wine, cigarettes, and toothpaste.
. Recommended Products is: 29350-73-0 and 51905-84-1.

Chamaecyparis formosensis Matsumura and C. obtusa var. formosana (Hayata) Rehder are important, precious, and well-known species grown in Asia. Renowned for excellent natural durability, their wood logs are regularly used as quality building materials or furniture. However, these two species have similar appearances, e.g., leaf, twig, wood, hardly distinguishable by the naked eye. The purpose of the present study is to phytochem. differentiate these two species using volatile compounds from the woods. Wood essential oils were obtained by 6-h hydrodistillation The chem. composition was identified by GC-MS, and semi-quantification was carried out to determine the content of each compound Furthermore, compounds with a significantly higher content than those of the other species were screened by t-test and principal component anal. (PCA). Results from semi-quantification and t-test showed that C. formosensis contained higher content of cis-myrtanol (ratio 37.1 ¡À 19.8), chamaecynone (11.0 ¡À 6.7), and ¦Á-eudesmol (8.5 ¡À 7.9), while C. obtusa var. formosana comprised mainly of ¦Á-terpineol (30.2 ¡À 10.1) and borneol (24.0 ¡À 16.1). Moreover, PCA results showed that the representative compounds of C. formosensis were cis-myrtanol and chamaecynone, while those of C. obtusa var. formosana were ¦Á-terpineol, borneol, and ¦Á-cadinol. Taken together, the above-mentioned results suggested significant compositional differences between these two species. For distinguishing the two kinds of wood, C. formosensis should be easily identified by its two characteristic compounds: cis-myrtanol and chamaecynone; while C. obtusa var. formosana could also be distinguished by its characteristic compounds: ¦Á-terpineol and borneol.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Wei, Cheng’s team published research in Arabian Journal of Chemistry in 2022-11-30 | CAS: 483-76-1

Efficient separation of Cinnamomum camphora leaf essential oil and in vitro evaluation of its antifungal activity. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Cinnamomum camphora leaf essential oil was extracted using enzymic-ultrasound pretreatment followed by microwave assisted extraction method and simultaneously studied as a mycelial growth inhibitor against five important pathogens which cause potato dry rot. The optimum EUP-MAE conditions with a real CEO yield of 19.23 ¡À 0.12 mg/g were obtained through Plackett-Burman design and Box-Behnken design as follows: 3% of enzyme dosage, 2 h of pretreatment time, 5 of pH, 210 W of ultrasound power, 50¡ãC pretreatment temperature, 16 mL/g of water to solid ratio, 30 min of microwave time and 500 W of microwave power. Compared to the reference methods, EUP-MAE possessed a highest CEO yield than these of ultrasound-microwave assisted extraction (U-MAE) and traditional hydrodistillation (HD). Gas chromatog.-mass spectrometry (GC-MS) anal. demonstrated that eucalyptol, camphor, and ¦Á-terpineol were the three main constituents of CEO. Results from in vitro antifungal activity assay revealed that the mycelial growths of all the five tested Fusarium solani, Fusarium culmorum, Fusarium trichothecioides, Fusarium sporotrioides, and Fusarium avenaceum were apparently affected by CEO. These findings not only provide a potential paradigm for the separation of plant essential oil, but also guarantee a promising utilization of the CEO for potato protection to control the Fusarium spp.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Huong, Le Thi’s team published research in Chemistry of Natural Compounds in 2022-09-30 | CAS: 483-76-1

Chemical Composition and Antimicrobial Activity of the Leaf Essential Oil of Vernonia solanifolia. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

This article discusses about chem. composition and antimicrobial activity of the leaf essential oil of Vernonia solanifolia. The leaves of Vernonia solanifolia were collected from Hanh Dich Commune and essential oil was obtained by hydrodistillation The instrumental anal. of the essential oil was achieved using gas chromatog. The antimicrobial activity was measured by the determination of MIC and median inhibitory concentration . The major constituents of the essential oil of Vernonia solanifolia have shown antimicrobial activity against E. faecalis, S. aureus, B. cereus, and C. albicans

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Kobayashi, Fumiyuki’s team published research in Journal of Food Processing and Preservation in 2022-08-31 | CAS: 483-76-1

Effect of various seasonings on the quality retention of dried mackerel (Scomber scombrus Linnaeus). Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

The effect of seasonings on the quality retention of dried mackerel (Scomber scombrus Linnaeus) was investigated by analyzing the components of the seasonings and prepared dried mackerel. The pH, water content, salt concentration, and inosinic acid content of dried mackerel were influenced by the water content of seasoning liquid The free amino acid content of dried mackerel depended on the seasoning liquid The DPPH radical-scavenging activity of mirin seasoning liquid was significantly higher than that of salt and chorizo, and that of black seven spices (shichimi) and chorizo seasoning powders was extremely high. The content of some aldehydes, alkenes, and alkane of dried mackerel flavored with mirin, shichimi, and chorizo was significantly lower than that flavored with salt. Hexanal concentration further decreased in dried mackerel flavored with shichimi and chorizo. Therefore, the use of shichimi and chorizo as seasoning powders was effective for maintaining the quality of dried mackerel. The production and consumption of dried fish have decreased yearly in Japan. Recently, two types of seasonings flavored with shichimi and chorizo have been, therefore, developed for preparing dried mackerel. These seasonings consisted of liquid and powder. This is the first attempt to use seasoning powders in the production of dried mackerel. This study demonstrated that the generation of fishy volatile components from dried mackerel was inhibited by the shichimi and chorizo seasoning powders.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Huong, Le Thi’s team published research in Chemistry of Natural Compounds in 2022-09-30 | CAS: 483-76-1

Essential Oil Compositions and Antimicrobial Activity of the Leaves and Rhizomes of Alpinia calcicola from Vietnam. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Essential oil compositions and antimicrobial activity of leaves and rhizomes of Alpinia calcicola rom vietnam. The min. inhibitory concentration (MIC) and median inhibitory concentration (IC50) values were measured by the microdilution broth susceptibility assay. The essential oils from the leaves and rhizomes of A. calcicola displayed antimicrobial activity against five of the seven tested microorganisms

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Coskun, Yasemin’s team published research in Flavour and Fragrance Journal in 2022-09-30 | CAS: 483-76-1

Influence of biotic and abiotic elicitors on artemisinin, quercetin, caffeic acid and essential oil production in Artemisia dracunculus L.. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Artemisia dracunculus L. (tarragon) is valuable for its medicinal uses such as antimalarial, antibacterial and anticancer. Biotechnol. methods need to be developed for the production of phytochem. compounds in plants with high and stable quality. Elicitation is one of the best tools for increasing secondary metabolites in various in vitro cultures. The current study determines the application of different concentrations of chitosan (25, 50, 100 and 150 mg/L) and UV-C (5/10, 5/15, 10/10 and 10/15 min/cm) as biotic and abiotic elicitors in tarragon leaf callus cultures. The main aim was to increase the accumulation of artemisinin, quercetin, caffeic acid and essential oil content. For this purpose, callus formation rates and morphol. features were also investigated. The results show that highest callus formation, weight and diameter were observed in UV-C treated cultures. HPLC analyses revealed significant high accumulation of artemisinin (1.9¦Ìg/g), quercetin (4.2¦Ìg/g) and caffeic acid (2.9¦Ìg/g) contents in 5/10 min/cm UV-C treated samples. GC-MS analyses of callus cultures indicate high production of total amount of monoterpenes in all chitosan applications, best in 25 mg/L (90.75%). The major compound was ¦Â-phellandrene in chem. composition of tarragon (19.61%) and increased the most in 10/15 min/cm UV-C application (43.39%). The results show that the phys. elicitor UV-C can be effectively used in tarragon callus culture for enhancing pharmacol. active compounds in industrial production

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Zhao, Mu’s team published research in Food Chemistry in 2022-08-15 | CAS: 483-76-1

Characterization of key aroma-active compounds in Hanyuan Zanthoxylum bungeanum by GC-O-MS and switchable GC x GC-O-MS. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

The present study sought to characterize the composition of volatile aroma compounds and key aroma-active compounds of dried Hanyuan Zanthoxylum bungeanum. The volatile aroma compounds were analyzed by the solid-phase microextraction (SPME) combined with gas chromatog.-olfactometry-mass spectrometry (GC-O-MS) and two-dimensional comprehensive gas chromatog.-olfactometry-mass spectrometry (GC x GC-O-MS). The key aroma-active compounds were analyzed by the aroma extract dilution anal. and odor activity value. A total of 72 volatile compounds were identified by GC-O-MS, of which 28 were aroma-active. Meanwhile, 116 volatile compounds were identified by GC x GC-O-MS, of which 43 were aroma-active. These results revealed that myrcene, (+)-limonene, (E)-¦Â-ocimene, ¦Â-cubebene, Germacrene D, cineole, linalool, and linalyl acetate were the key aroma-active compounds of dried Hanyuan Zanthoxylum bungeanum.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Skoric, Marijana’s team published research in Industrial Crops and Products in 2022-09-15 | CAS: 483-76-1

Bioactivity-guided identification and isolation of a major antimicrobial compound in Cistus creticus subsp. creticus leaves and resin “”ladano””. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Cistus creticus subsp. creticus is a shrubby Mediterranean plant used since ancient times in folk medicine for the treatment of different diseases. C. creticus extracts and resin contain different types of secondary metabolites, such as terpenoids (predominantly labdane type diterpenoids), and phenylpropanoids. Growth conditions seem to influence the content of labdane-type diterpenes and flavan-3-ols in leaves of C. creticus subsp. creticus. Histochem. staining of leaves ¡ä trichomes and comprehensive phytochem. characterization of resin, leaves and their exudates, indicated that long-stalked capitate trichomes of C. creticus subsp. creticus, grown both in vitro (IV) and in greenhouse (GH), are capable of producing bioactive oleoresin-related terpenoids and phenylpropanoids compounds Bioactivity-guided approach was implemented in search for the major antibacterial compound in C. creticus resin against two Gram-neg. (Escherichia coli and Pseudomonas aeruginosa) and two Gram-pos. bacteria (Bacillus cereus and Micrococcus flavus). Bioautog. assay on TLC plates with separated components of Cistus resin extract, revealed a pronounced zone of microbial growth inhibition, corresponded to a highly active compound with Rf values of 0.45, structurally characterized and identified as ent-3¦Â-acetoxy-13-epi-manoyl oxide. This finding opens the route for focusing on isolation and functional characterization of genes involved in the biosynthesis of ent-3¦Â-acetoxy-13-epi-manoyl oxide and its precursor ent-3¦Â-hydroxy-13-epi-manoyl oxide, with the aim to establish sustainable in vitro biotechnol. protocols for its large-scale production in homologous and heterologous plant and microbial hosts.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Jeldi, Lamya’s team published research in South African Journal of Botany in 2022-07-31 | CAS: 483-76-1

Chemical composition, antifungal and antioxidant activities of wild and cultivated Origanum compactum essential oils from the municipality of Chaoun, Morocco. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Origanum compactum is a medicinal species endemic to Morocco and highly exploited for its therapeutic properties. In the present study, we examined the chem. composition and biol. activities of the essential oils from wild and cultivated O. compactum. The chem. composition was analyzed by gas chromatog. coupled with mass spectrometry (GC/MS). The yield of essential oils was 3.5% for the wild plants and 3.4% for the cultivated plants. Twelve compounds have been identified in the essential oils of wild plants. Carvacrol was the predominant compound (59.0%), followed by p-cymene (18.4%) and then by ¦Ã-terpinene (8.4%). For the cultivated plants, 27 compounds were identified. Here again, carvacrol was the predominant compound (45.3%), followed by p-cymene (22.2%) and by ¦Ã-terpinene (10.1%). The antifungal activity of essential oils was evaluated against four Candida strains using the aromatogram method, the min. inhibitory concentration (MIC) and the min. fungicidal concentration (MFC). In semi-solid medium, essential oils were active against all the strains tested. In liquid medium, MIC values ranged from 216 to 234¦Ìg/mL, while the MFC was 288¦Ìg/mL. Antioxidant activity was investigated by 2,2-diphenyl-1,1,picrylhydrazil radical (DPPH) and the findings showed that the essential oils of both plants have a good antioxidant effect. In conclusion, domestication is a practical approach to preserve O. compactum from extinction without compromising its biol. activities. Besides, the essential oils of O. compactum could be a promising and sustainable alternative to replace the synthetic compounds used currently in pharmaceutical and food industries.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Pintatum, Aknarin’s team published research in Arabian Journal of Chemistry in 2022-10-31 | CAS: 483-76-1

Volatile constituents of Amomum argyrophyllum Ridl. and Amomum dealbatum Roxb. and their antioxidant, tyrosinase inhibitory and cytotoxic activities. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

The volatile components from fresh rhizomes and leaves of Amomum argyrophyllum Ridl. and Amomum dealbatum Roxb. were performed using HS-SPME and charac-terized by GC-MS. A total of 49, 47, 49, and 34 compounds were identified from the rhizomes and leaves of A. argyrophyllum and A. dealbatum, resp. The major components were ¦Â-pinene, ¦Á-pinene, and o-cymene. The rhizome extracts exhibited total phenolic content of 2.9 ¡À 0.5 and 2.1 ¡À 0.6 mg gallic acid equivalent The IC50 values of DPPH and ABTS were 179.8 ¡À 3.9 ¦Ìg/mL, 392.9 ¡À 2.6 ¦Ìg/mL, 120.3 ¡À 2.5 ¦Ìg/mL, and 328.6 ¡À 3.3 ¦Ìg/mL, resp. The FRAP values were 76.5 ¡À 7.8 and 84.9 ¡À 4.4 ¦ÌM ascorbic acid equivalent The extracts showed weak antibacterial activity and tyrosinase inhibitory activity of 69.0 ¡À 3.6 and 53.7 ¡À 7.4 mg kojic acid equivalent The cytotoxicity effect was assessed with the MTT assay at 200 ¦Ìg/mL. The extracts showed no toxicity. In addition, the anti-inflammatory properties of extracts were evaluated, and showed potential to inhibit nuclear factor-¦ÊB (NF-¦ÊB) activity.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem