483-76-1 | Page 4 of 10 | Heterocyclic Building Blocks-Benzoxazole

Mahanta, Bhaskar Protim’s team published research in Industrial Crops and Products in 2022-06-30 | CAS: 483-76-1

Phytotoxic essential oil from black turmeric (Curcuma caesia Roxb.) rhizome: Screening, efficacy, chemical basis, uptake and mode of transport. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

1. Trivial name: delta-Cadinene.
2. It’s mainly derived from flue-cured tobacco, burley tobacco and flavoured tobacco, it has a strong aroma and a good fixing effect, suitable for perfume, cosmetics, can also be used in wine, cigarettes, and toothpaste.
. Recommended Products is: 29350-73-0 and 51905-84-1.

Plant-based phytotoxins play an important role in plant-plant interaction and are of great promise for the development of bioherbicide. In this study, screening of essential oils from six different Curcuma rhizomes identified black turmeric (Curcuma caesia Roxb.) oil as an efficient growth inhibitor in wheatgrass coleoptile bioassay (IC50 57.1¦Ìg/mL). The phytotoxic efficacy of this oil was further confirmed through the dose dependent (10.0-300.0¦Ìg/mL) inhibition of germination, coleoptile and radicle growth of wheatgrass seeds in water medium (IC50 176.7, 90.6 and 93.0¦Ìg/mL resp.) and the pre-germinated seeds in agar medium. Activity-guided fractionation and purification of the crude oil identified curzerenone, a major furanosesquiterpene in this oil as the most active phytotoxin (IC50 13.0¦Ìg/mL in coleoptile bioassay; 188.3, 34.7 and 36.7¦Ìg/mL resp. in water medium). Structure-activity relationship study indicated the importance of all the functional groups for its phytotoxicity. A significant contribution by the oxygenated monoterpenes towards oil phytotoxicity was also evidenced. Though inhibitory efficacy of the oil was comparatively weak in soil, a profound activity through aerial diffusion was observed against germination and/or growth of fresh and pre-germinated wheatgrass seeds (IC50 1.4-6.2 mg/L air). The study also confirmed the uptake of active phytotoxins with no detectable transformation by the seeds in water and their persistence in the soil for at least one and half months. Further, its applicability was demonstrated through an efficient post-emergence growth inhibition (IC50 37.0-81.4¦Ìg/mL) of bermudagrass weed in water and agar medium.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Deba-Rementeria, Shuyana’s team published research in International Journal of Food Science and Technology in 2022-08-31 | CAS: 483-76-1

Orange peel fermentation using Lactiplantibacillus plantarum: microbiological analysis and physico-chemical characterisation. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Summary : To find an innovative use for orange peels discarded in the orange juice-making process, a fermentative process was assessed using a Lactiplantibacillus plantarum strain. Blanched or rinsed peels were submerged in a 5% NaCl-3% inoculated sucrose brine for 10 days. Total soluble solids, pH, sugars and total aerobic and anaerobic counts were determined in the brines to characterize the process. The final products were characterised by instrumental texture, color and volatile composition The blanching pretreatment had a significant effect on the whole process and the final product characteristics. Anaerobic bacteria total counts were significantly higher in the blanched samples during the whole fermentation, and pH decreased significantly slower in these samples than in the rinsed ones. Rinsed samples were characterised by higher aerobic total counts, higher sucrose consumption and higher glucose, fructose and polyalcs. production The texture was softer in the pretreated samples, probably due to the blanching process rather than the fermentation The volatile composition was quite similar between samples, although it was different from one of the raw orange peels due to a significant decrease in various volatile compounds

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Fusani, Pietro’s team published research in Industrial Crops and Products in 2022-11-01 | CAS: 483-76-1

Composition and biological activity of essential oils from Artemisia roxburghiana Besser and Elsholtzia fruticosa Rehder cultivated in Italy. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

The plants Artemisia roxburghiana Besser and Elsholtzia fruticosa Rehder were evaluated as innovative crops for the production of essential oils with valuable biol. activity. For both species, Clevenger distillation resulted in high essential oil contents of 1.08 and 1.79 mL¡¤100 g-1 dry weight for A. roxburghiana and E. fruticosa, resp. According to the results of GC/FID and GC/MS analyzes, the composition of essential oil of A. roxburghiana was characterized by cis-thujone (23.05%), 1,8-cineole (21.56%), and camphor (13.82%), while E. fruticosa oil was rich in 1,8-cineole (50.06%) and ¦Ã-terpinene (14.11%). The bioactivity of the oils of the two species was evaluated in vitro against both pathogenic Gram-pos. and Gram-neg. bacterial strains by disk diffusion assay and determination of the minimal inhibitory concentration They were also tested as natural insecticides by carrying out mortality and fecundity analyzes against the aphid Mizus persicae. E. fruticosa oil showed higher antibacterial activity compared to A. roxburghiana, particularly against Staphylococcus aureus (MIC 2.0 and 62.5 mg¡¤mL-1) and Escherichia coli (MIC 7.8 and 62.5 mg¡¤mL-1). Both plant species revealed high aphicidal activity against the polyphagous pest M. Persicae according to the nymph mortality and fecundity reduction, and their efficacy was comparable to that of azadyrachtin. This study shows the prospects of the two investigated species as possible innovative crops for the production of essential oils to be employed in agro-industry.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Di Sotto, Antonella’s team published research in Industrial Crops and Products in 2022-09-01 | CAS: 483-76-1

Phytochemical and pharmacological profiles of the essential oil from the inflorescences of the Cannabis sativa L.. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Industrial hemp (Cannabis sativa L.) female inflorescences have long been considered as waste material in the hemp production chain. However, past studies focused on the valorization of female inflorescences as high-quality byproducts with promising health-promoting applications. In line with this evidence, the present research investigated the phytochem. and pharmacol. properties with a comparative approach on two essential oils (EOs) obtained from the inflorescences of the industrial hemp varieties Kompolti and Tisza. The EOs composition in terpenes and terpenophenols was determined The effects of the EOs in modulating the viability of different cancer cell lines was investigated. Whereas, in hypothalamic HypoE22 cells, the release of dopamine, norepinephrine, and serotonin was measured, as an index of neuromodulatory activity. Moreover, the EO mycostatic properties were explored towards different dermatophyte species. The prominent terpenes were iso-caryophyllene, ¦Á-humulene, and ¦Â-caryophyllene oxide in both Kompolti and Tisza EOs, whereas cannabidiol and cannabigerolic acid were the main terpenophenols, resp. Both essential oils inhibited the viability of different cancer cells; particularly, the essential oil of Tisza variety displayed a marked cytotoxicity in cholangiocarcinoma cells. A possible role of both terpenophenols and caryophyllane sesquiterpenes as bioactive anticancer compounds has been hypothesized. While cannabidiol could contribute to the stimulation of hypothalamic serotonin release by Kompolti EO. The essential oils also produced antimycotic effects, for which ¦Â-caryophyllene oxide could be partly responsible. Overall, the present findings highlight pharmacol. properties of Kompolti and Tisza EOs, which deserve further investigations and strengthen the interest in industrial hemp inflorescences as valuable source of bioactive extracts and compounds

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Xavier, Julia Karla A. M.’s team published research in Chemistry & Biodiversity in 2022-10-31 | CAS: 483-76-1

The volatile profiles and DNA barcodes of Lauraceae species from the Ocotea complex with occurrence in the Brazilian Amazon. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

The Ocotea complex accommodates most of the taxonomic diversity of Neotropical Lauraceae with economic importance and biol. potential attributed to their essential oils (EOs) and extracts However, the botanical taxonomy has had limitations due to the difficulty of identifying and delimiting species and genera. The chem. and mol. markers of Ocotea complex species in Para state, Brazil, were assessed according to their EO compositions and DNA sequences of matK, trnL-trnF, and ITS regions. The multivariate anal. of EOs constituents has classified them into two main clusters characterized by oils rich in (I) terpenoids and phenylpropanoids and (II) sesquiterpenes. We conducted a phylogenetic anal. of species based on DNA barcode sequences on the Bayesian Inference (PP: 0.70-1,0) and Maximum Likelihood (BS: 72-100 %). The comparison between the volatile profiles and phylogenetic data indicates two main groups for these species collected from the Ocotea complex.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Baranauskiene, Renata’s team published research in Food Research International in 2022-10-31 | CAS: 483-76-1

Valorisation of Roman chamomile (Chamaemelum nobile L.) herb by comprehensive evaluation of hydrodistilled aroma and residual non-volatile fractions. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Valorization of botanicals for the development of natural food-grade ingredients is an important task in terms of sustainability and processing waste reduction In this study, Roman chamomile (Chamaemelum nobile L.) herb was collected at six different vegetation phases in the period 26 May – 23 August 2019 and subjected to biorefining into the several valuable fractions. The yield of hydro-distilled essential oil (EO) was in the range of 0.22% (intensive vegetative growth) to 0.80% (full flowering). Angelic, isobutyric, butyric and methacrylic acid esters and some monoterpene and sesquiterpene derivatives were the major EO constituents: 3-methylpentyl angelate (20.11-27.56%), methallyl angelate (7.28-10.33%), isoamyl angelate (5.57-9.02%), iso-Bu angelate (4.84-6.79%), 2-methylbutyl angelate (3.11-6.32%), 3-methylamyl methacrylate (5.04-6.17%), 3-methylpentyl isobutyrate (4.29-6.64%), 3-methylamyl isobutyrate (4.29-6.64%), ¦Á-pinene (1.61-6.37%) and pinocarvone (1.46-4.67%). In order to valorize water soluble and solid EO distillation residues their antioxidant potential was evaluated by several in vitro assays: water extracts were considerably stronger antioxidants than acetone extracts isolated from the solid residues. Water extracts of the plants collected at flowering phases were the strongest antioxidants; their TPC, FRAP and ORAC values were up to 143.2 mg gallic acid equivalent/g, 650, and 5601 ¦Ìmol TE/g dry extract, resp., while effective concentrations (EC50) of DPPH? and ABTS?+ scavenging, were down to 0.59 and 0.49 mg/mL, resp. Among 7 tentatively identified by UPLC/Q-TOF/MS phenolic constituents the intensity of mol. ion of 3,5-dicaffeoyl quinic acid was the largest. The results obtained may assist for developing flavorings, antioxidants and health beneficial preparations from C. nobile extracts

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Shahrivari, Saba’s team published research in Scientific Reports in 2022-12-31 | CAS: 483-76-1

A comprehensive study on essential oil compositions, antioxidant, anticholinesterase and antityrosinase activities of three Iranian Artemisia species. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Artemisia is one of the most diverse genera in the Asteraceae family. The genus is wildly distributed in Irano-Turanian habitats and includes 34 species in Iran. Here, for the first time the essential oil variability, antioxidants and anti-cholinesterase and anti-tyrosinase activities of extracts of three Artemisia species (A. tournefortiana, A. khorassanica, A. haussknechtii), from different regions of Iran were evaluated. Based on GC-MS analyses, 81.84% to 98.70% of the total oils were identified. Cluster anal. grouped the studied populations in three different chemotypes. The highest and the lowest essential oil contents were observed in A. khorassanica and A. haussknechtii species, resp. Camphor, en-in-dicycloether, 1,8-cineole and (Z)-¦Â-farnesene were the dominant components of essential oil in investigated ecotypes. The results revealed that the total phenol content was higher in A. tournefortiana collected from Kerman and A. haussknechtii collected from Chaharmahal and Bakhtiari. However, the lowest phenol content was recorded for A. haussknechtii collected from Isfahan province. The highest flavonoids content was found in A. tournefortiana collected from West Azerbaijan and A. khorassanica collected from North Khorasan. The highest FRAP antioxidant activity was observed in A. tournefortiana (Kerman) and the lower amount was in A. haussknechtii collected from Kohgiluyeh and Boyer-Ahmad. The highest antioxidant activity by DPPH method was in A. khorassanica collected from South Khorasan and the lowest activity was in Isfahan’s A. haussknechtii. The acetycholine esterase inhibitory activity was higher in A. tournefortiana collected from West Azerbaijan; and the lowest activity was in A. haussknechtii collected from Chaharmahal and Bakhtiari province. The highest tyrosinase inhibitory activity was in A. khorassanica collected from North Khorasan; and the lowest was in A. haussknechtii collected from Chaharmahal and Bakhtiari.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Caputo, Lucia’s team published research in Scientific Reports in 2022-12-31 | CAS: 483-76-1

Impact of drying methods on the yield and chemistry of Origanum vulgare L. essential oil. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Oregano (Origanum vulgare L.) is mainly cultivated, both as fresh and dried herb, for several purposes, such as ailments, drugs, and spices. To evaluate the influence of some drying methods on the chem. composition of the essential oil of oregano, its aerial parts were dehydrated by convective drying techniques (shade, static oven), microwave-assisted heating (three different treatments) and osmotic treatment. The oils were analyzed by GC-FID and GC-MS. The highest essential oil yield was achieved from microwave and shade drying methods. In total, 39 components were found, with carvacrol (ranging from 56.2 to 81.4%) being the main constituent; other compounds present in lower amounts were p-cymene (1.6-17.7%), ¦Ã-terpinene (0.8-14.2%), ¦Á-pinene (0.1-2.1%), thymol Me ether (0.4-1.8%) and thimoquinone (0.5-3.5%). The essential oil yields varied among the different treatments as well as the relative compositions The percentages of p-cymene, ¦Ã-terpinene and ¦Á-pinene decreased significantly in the dried sample compared with the fresh sample; on the other hand, carvacrol, isoborneol and linalool increased significantly in the dried materials. The choice of the drying method for obtaining the essential oil therefore appears crucial not only in relation to the higher yield but also and above all in reference to the percentage presence of components that can direct the essential oil toward an appropriate use.

Impact of drying methods on the yield and chemistry of Origanum vulgare L. essential oil. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Yuan, Yue’s team published research in Journal of Food Processing and Preservation in 2022-07-31 | CAS: 483-76-1

Chemical composition, antimicrobial activities, and microencapsulation by complex coacervation of tea tree essential oils. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

The chem. composition and antibacterial activities of five tea tree essential oils are analyzed. GC-MS anal. reveals that 1,8-cineole, terpinen-4-ol, p-cymene, ¦Á-terpineol, and ¦Á-pinene are the representative composition By comparison of the diameter of inhibition zone, oil of Melaleuca leucadendron Linn. (TTO1) shows the best antimicroorganism effects on Staphylococcus aureus, Escherichia coli, and Pseudomonas aeruginosa. Subsequently, the coacervation between gelatin (GE) and gum Arabic (GA) for microencapsulation as functions of pH, GE-GA ratio, emulsifiers, homogenization speed and time, and microfluidization are investigated. The optimum parameters for the coacervation effectiveness of TTO1 and emulsifier S20 are emulsification at 10,000 rpm for 1 min, the ratio of GE-GA as 1:2 with a concentration of 1%, and pH of 4.0. The microcapsules have a particle size of 52.601¦Ìm, spherical multinuclear morphol., and strong phys. stability which show potential for their application in the controlled release of reactive materials and anticorrosion of cosmetics and foods. Novelty impact statement : The tea tree essential oils showed different antimicrobial potential toward the bacterial species tested. After microfluidization, tea tree essential oil microcapsules prepared by a complex coacervation method generated smaller particles with greater encapsulation efficiency. The microcapsules synthesized in this study can be utilized as a novel preservative in the food industry or used for the encapsulation of other bioactive compounds

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Li, Jiahao’s team published research in Industrial Crops and Products in 2022-11-15 | CAS: 483-76-1

Chemical compositions and anti-mosquito activity of essential oils from Pericarpium Citri Reticulataes of different aging years. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Mosquitoes are well-known vectors of malaria, dengue fever, chikungunya, yellow fever, Zika and many other diseases, and have become a great threat to public health. Nowadays, chem. insecticides are widely used for the control of mosquitoes. However, their widespread use has created some serious problems, such as insecticide resistance, environmental pollution, and toxicity to human beings. With the objectives to develop novel botanical and eco-friendly insecticides for mosquitoes, in this study we examined the chem. compositions of the essential oils (EOs) from different aging years of Pericarpium Citri Reticulatae (PCR, Guangchenpi in Chinese), and investigated their anti-mosquito activity in details. As a result, 39, 44, 48, and 40 main components were identified from the 1-, 5-, 10-, and 15-yr PCR EOs, resp. For each PCR EO, D-limonene (47.90-56.39%) and ¦Ã-terpinene (14.98-17.03%) were the major components. These PCR EOs showed potent larvicidal activity against Aedes albopictus (A. albopictus) larvae (LC50 = 54.50-68.23 ppm ppm), and some of the major components were also very active, including D-limonene (LC50 = 56.17 ppm), ¦Ã-terpinene (LC50 = 64.28 ppm), ¦Â-myrcene (LC50 = 54.51 ppm) and terpinolene (LC50 = 57.69 ppm). These PCR EOs exhibited similar larvicidal activity, and their insecticidal activity may be attributed to the major constituents such as D-limonene, ¦Ã-terpinene and terpinolene. In addition, thymol was found more effective against A. albopictus adults (LC50 = 96.82 ppm) than the other components, such as Me 2-(methylamino) benzoate (LC50 = 382.10 ppm) and ¦Á-terpineol (LC50 = 507.54 ppm), and this compound could be one of the active components responsible for the adulticidal activity. Enzyme inhibition assays suggested that the activity of acetylcholinesterase, mixed function oxidase and esterase were significantly inhibited, which may result in the mortality of A. albopictus larvae. The present findings clearly demonstrated that naturally-occurring PCR EOs and the functional components display potent insecticidal activity against A. albopictus larvae and adults, and therefore, strongly suggest that PCR EOs and the main components are exploitable as botanical insecticides for the control of mosquitoes.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem