483-76-1 | Page 8 of 10 | Heterocyclic Building Blocks-Benzoxazole

Luca, Simon Vlad’s team published research in Industrial Crops and Products in 2022-11-01 | CAS: 483-76-1

Supercritical CO2 extraction of hemp flowers: A systematic study to produce terpene-rich and terpene-depleted cannabidiol fractions. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

1. Trivial name: delta-Cadinene.
2. It’s mainly derived from flue-cured tobacco, burley tobacco and flavoured tobacco, it has a strong aroma and a good fixing effect, suitable for perfume, cosmetics, can also be used in wine, cigarettes, and toothpaste.
. Recommended Products is: 29350-73-0 and 51905-84-1.

Despite their high-added value, terpenes currently have limited exploitation in the hemp industry, often ending up in the sidestream of cannabidiol extraction and/or purification In this work, the influence of different combinations of pressures (80-300 bar) and temperatures (40-50¡ãC) on the recovery of three representative terpenes (caryophyllene, humulene, caryophyllene oxide) and, secondarily, cannabidiol, from hemp flowers by supercritical fluid extraction with carbon dioxide (SC-CO2) was investigated systematically. In the preliminary experiments, the influence of the particle size and storage time on the SC-CO2 process was evaluated, being noticed that a good recovery of the target compounds was obtained with freshly grounded hemp flowers. By comparing the extraction curves obtained for the studied pressure and temperature conditions, it was observed that pressures from 90 to 110 bar and temperatures from 40¡ã to 50¡ãC could allow a fast and efficient extraction of the three hemp terpenes. In contrast, higher pressures (200-300 bar) are needed for a superior recovery of cannabidiol. Based on the isocratic experiments, the gradient temperature (from 40¡ã to 50¡ãC) and pressure (from 100 to 300 bar) conditions were selected for the online fractionation of hemp flowers; thus, the proof-of-concept step-gradient SC-CO2 experiment generated terpene-rich and terpene-depleted cannabidiol fractions. In conclusion, our study brings essential knowledge on selecting the SC-CO2 process parameters for efficiently extracting hemp terpenes or performing the simultaneous removal of terpenes and extraction of cannabidiol from hemp flowers using step-gradient SC-CO2.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Srivastava, Shubham’s team published research in Industrial Crops and Products in 2022-09-01 | CAS: 483-76-1

Chemical composition of phenylpropanoid rich chemotypes of Ocimum basilicum L. and their antimicrobial activities. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Ocimum basilicum L., is most popular fragrant herb renowned for its immense application. However, a plethora of studies revealed terpenoids and phenylpropanoids as marker chems. with known identities. We herein report two unique chemotypes developed in CSIR-CIMAP for their compositional variability and biol. activities. Essential oils obtained from aerial parts of both the chemotypes were analyzed in capillary gas chromatog. and mass spectrometry systems on 5% diphenyl- and cyclodextrin coated fused silica columns. The statistical anal. was carried out to validate the phytochem. data of consecutive years and also to calculate the variability. The phenylpropanoids dominated the volatile fractions of chemotype II (72.5-77.5%) in comparison to chemotype I (29.8-40.0%) essential oil. In the contrary, sesquiterpenoids (16.4-17.4%) and monoterpenoids (33.5-43.9%) contributed oil composition of chemotype I in diverse proportions. The presence of single images of R-(+)-camphor and R-(-)-linalool were established in both the oils analyzed on a Et substituted cyclodextrin-based column. Essential oils were tested for biol. activities against C. albicans, S. aureus, and E. coli. meta-Eugenol, the marker compound isolated from chemotype I showed best inhibition against C. albicans. In conclusion, meta-eugenol-rich chemotype I with high essential oil yield (0.1-0.8%) was identified as an alternative source for meta-eugenol.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Vieira, Luiza V.’s team published research in Food Chemistry in 2022-10-01 | CAS: 483-76-1

The effects of drying methods and harvest season on piperine, essential oil composition, and multi-elemental composition of black pepper. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

This study aimed to evaluate the piperine content, essential oil composition, and multi-elemental composition of black pepper samples according to different drying methods and harvest season. Differences in essential oil composition and B, Ca, K, Mg, and S were noted according to sampling campaign, indicating secondary metabolism plant alterations. Mech. drying resulted in essential oil composition changes due to high temperature exposure during processing. Increases in Fe and Cr contents when employing mech. dryers with direct heating were also observed, due to direct contact with metallic structures and particulate material from the burning process. The As and Pb contents of several samples were higher than the maximum permissible limits, reaching 0.46 and 0.56 mg kg-1, resp., thus surpassing legislation safety limitations for human consumption.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Isidorov, Valery A.’s team published research in Journal of Atmospheric Chemistry in 2022-09-30 | CAS: 483-76-1

Emission of volatile organic compounds by plants on the floor of boreal and mid-latitude forests. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

The forests of the boreal and mid-latitude zones of the Northern Hemisphere are the largest source of reactive volatile organic compounds (VOCs), which have an important impact on the processes occurring in the atm. boundary layer. However, the composition of biogenic emissions from them remains incompletely characterized, as evidenced by the significant excess OH radical concentrations predicted by models in comparison with those observed under the forest canopy. The missing OH sink in the models may be related to the fact that they do not take into account the emission of highly reactive VOCs by vegetation on the forest floor. In this work, we report the results of laboratory determinations of the composition of VOCs emitted by representatives of different groups of plants that form the living soil cover (LSC) in the forests of the boreal and mid-latitude zones: bryophytes, small shrubs, herbaceous plants, and ferns. In the chromatograms of volatile emissions of all 11 studied plant species, 254 compounds with carbon atoms ranging in number from two to 20 were registered. All plants were characterized by the emission of terpenes, accounting for 112 compounds, and the second largest group (35 substances) was formed by carbonyl compounds Both groups of compounds are characterized by high reactivity and are easily included in the processes of gas-phase oxidation with the participation of radicals HO, NO3 and ozone. These data indicate the importance of a thorough study of the so far disregarded source of VOCs, i.e., the LSC in forests.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Kemel, Meriem’s team published research in Chemistry Africa in 2022-08-31 | CAS: 483-76-1

Chemical Composition, Antioxidant and Anticorrosive Activities of Hammada articulata Essential Oil. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

The objective of this research was to investigate the chem. composition of the essential oil of Hammada articulata obtained by steam distillation and to investigate its antioxidant and anticorrosive activities. Gas chromatog.-mass spectrometry anal. of this oil resulted in the identification of 46 compounds, which accounted for 97.0% of the total oil. The major components found in this oil were hexahydrofarnesyl acetone (11.9%), ¦Â-bisabolene (10.7%), eugenol (7.7%) and 2-methyldecalin (5.3%). The DPPH radical scavenging technique was used to assess antioxidant activity. The sample of essential oil presented good antioxidant activity. This oil was tested as a corrosion inhibitor of stainless steel in 0.5 M HCl using weight loss measurements and electrochem. polarization methods. The corrosion rate of stainless steel was decreased in the presence of essential oil. The inhibition efficiency was found to increase with oil concentration to attain 96.68% at 1000 ppm. The adsorption of inhibitor on the stainless steel surface was found to be a spontaneous process and obeys Langmuir¡äs adsorption isotherm.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Yohana, Revocatus’s team published research in Malaria Journal in 2022-12-31 | CAS: 483-76-1

Anti-mosquito properties of Pelargonium roseum (Geraniaceae) and Juniperus virginiana (Cupressaceae) essential oils against dominant malaria vectors in Africa. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

More than 90% of malaria cases occur in Africa where the disease is transmitted by Anopheles gambiae and Anopheles arabiensis. This study evaluated the anti-mosquito properties of Juniperus virginiana (JVO) and Pelargonium roseum (PRO) essential oils (EOs) against larvae and adults of An. gambiae sensu lato (s.l.) from East Africa in laboratory and semi-field conditions. EOs was extracted from the aerial green parts of Asian herbs by hydrodistillation Their constituents were characterized by gas chromatog.-mass spectrometry (GC-MS). Larvicidal activities of JVO, PRO, and PRO components [citronellol (CO), linalool (LO), and geraniol (GO)] were investigated against An. gambiae sensu stricto (s.s.). The percentage of knockdown effects and mortality rates of all oils were also evaluated in the adults of susceptible An. gambiae s.s. and permethrin-resistant An. arabiensis. GC-MS analyses identified major constituents of JVO (sabinene, dl-limonene, ¦Â-myrcene, bornyl acetate, and terpinen-4-ol) and PRO (citronellol, citronellyl formate, L-menthone, linalool, and geraniol). Oils showed higher larvicidal activity in the laboratory than semi-field trials. The LC50 values for JVO/PRO were computed as 10.82-2.89/7.13-0.9 ppm and 10.75-9.06/13.63-8.98 ppm in laboratory and semi-field environments, resp. at exposure time of 24-72 h. The percentage of knockdown effects of the oils were also greater in An. gambiae s.s. than in An. arabiensis. Filter papers impregnated with JVO (100 ppm) and PRO (25 ppm) displayed 100% mortality rates for An. gambiae s.s. and 3.75% and 90% mortality rates, for An. arabiensis populations, resp. Each component of CO, LO, and GO exhibited 98.13%, 97.81%, and 87.5%, resp., and a mixture of the PRO components indicated 94.69% adult mortality to permethrin-resistant An. arabiensis. The findings of this study show that PRO and its main constituents, compared to JVO, have higher anti-mosquito properties in terms of larvicidal, knockdown, and mortality when applied against susceptible laboratory and resistant wild populations of An. gambiae s.l. Consequently, these oils have the potential for the development of new, efficient, safe, and affordable agents for mosquito control.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Sripahco, Teerapong’s team published research in Scientific Reports in 2022-12-31 | CAS: 483-76-1

Chemical composition, antioxidant, and antimicrobial activity of Elsholtzia beddomei C. B. Clarke ex Hook. f. essential oil. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

The essential oil of Elsholtzia beddomei C. B. Clarke ex Hook. f. was investigated for its chem. composition and tested for antioxidant and antimicrobial activities. The E. beddomei essential oil was extracted using hydrodistillation for 4 h (yield of 1.38% weight/weight). Forty-three volatile compounds were identified in the E. beddomei essential oil, including linalool (83.67%), perillaldehyde (4.68%), neral (3.68%), perillene (1.65%), E-caryophyllene (1.55%), and ¦Á-zingiberene (1.06%) as the major compounds The antioxidant activity of the E. beddomei essential oil was determined using 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical and 2,2-azino-bis(3-ethylbenzothiazoline-6-sulfonic acid) (ABTS) radical cation scavenging activity. The IC50 values calculated using the DPPH and ABTS methods were 148.31 and 172.22¦Ìg/mL, resp. In addition, using disk diffusion and broth microdilution methods, the antimicrobial activities of the E. beddomei essential oil against Escherichia coli, Pseudomonas aeruginosa, Enterobacter aerogenes, Staphylococcus aureus, Staphylococcus epidermidis, Bacillus subtilis, and Candida albicans were evaluated. The E. beddomei essential oil possessed an inhibitory effect with the min. inhibitory concentration in the range of 31.25-250.00¦Ìg/mL among these pathogens. The results indicated that E. beddomei essential oil is an alternative raw material of food, and medicinal products for use in pharmaceutical applications.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Bouymajane, Aziz’s team published research in International Journal of Food Microbiology in 2022-12-16 | CAS: 483-76-1

Chemical profile, antibacterial, antioxidant, and anisakicidal activities of Thymus zygis subsp. gracilis essential oil and its effect against Listeria monocytogenes. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

In this work, the chem. composition of Thymus zygis subsp. gracilis collected from Ifrane, Morocco, along with the evaluation of the antibacterial, anti-biofilm of Listeria monocytogenes activities, larvicidal effect against L3 larvae of Anisakis, and antioxidant properties of its essential oil (TZG-EO), are reported. GC-MS and GC-FID analyses highlighted the presence of 84 volatile components and strong bactericidal and anti-biofilm activities against L. monocytogenes at a concentration of 0.02 % were demonstrated. Also, larvicidal effect against Anisakis larvae at concentrations of 0.01 and 0.005 % was attained leading to the death of all tested larvae within 4 h. The in situ antibacterial activity of TZG-EO (0.01 and 0.005 %) in smoked fish showed high efficiency against L. monocytogenes growth. TZG-EO could be used as potential antibacterial and larvicidal agents for fighting against foodborne pathogens and extending shelf life of food products.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Sriramavaratharajan, Venkatraman’s team published research in Process Biochemistry (Oxford, United Kingdom) in 2022-07-31 | CAS: 483-76-1

Multi target interactions of essential oil nanoemulsion of Cinnamomum travancoricum against diabetes mellitus via in vitro, in vivo and in silico approaches. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

This study reports antidiabetic activity of leaf essential oil (EO) of Cinnamomum travancoricum from the Western Ghats, India via in vitro , in vivo and in silico methods. EO was characterized by GC-MS and GC-FID. Essential oil nanoemulsions (EN) were prepared and characterized. Antidiabetic potential was evaluated through in vitro assays namely, ¦Á-amylase and ¦Á-glucosidase inhibition, glucose uptake and insulin secretion assays. In vivo study was conducted on STZ-induced diabetic Wistar rats. Mol. docking was conducted to find the lead antidiabetic compounds Of the 42 compounds identified in the EO, ¦Á-phellandrene (5.9%), ¦Â-phellandrene (12.6%), linalool (23.6%), safrole (6.8%) and shyobunol (5.1%) were major constituents. Of the two ENs formulated, 1:2 ratio (EO to surfactants) was better in zeta size (51.4 nm) and potential (-30.9). In vitro results were impressive. EN lowered elevated blood glucose level to normal (p < 0.01) and improved the insulin secretion (p < 0.01) in diabetic rats. Further, serum AST, ALT, ALP, triglyceride and pancreatic ¦Â-cell damage were seen reduced (p < 0.05). Mol. docking studies showed minor constituents of EO, namely, ¦Ä-cadinene, elemol, spathulenol and ¦Á-copaen-11-ol playing active role in antidiabetic activity through ¦Á-amylase, ¦Á-glucosidase, insulin receptor, and insulin secretion proteins. Multi target interactions of essential oil nanoemulsion of Cinnamomum travancoricum against diabetes mellitus via in vitro, in vivo and in silico approaches. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Davari, Mahdi’s team published research in Archives of Microbiology in 2022-08-31 | CAS: 483-76-1

Mycelial inhibitory effects of antagonistic fungi, plant essential oils and propolis against five phytopathogenic Fusarium species. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Fusarium spp. are considered as one of the most devastating plant pathogenic fungi worldwide. In this study, the effect of essential oil (EO) of Mentha longifolia, M. spicata, Achillea sp. and Foeniculum vulgare, ethanolic extract of Propolis (EEP), and Trichoderma harzianum T447 and T. hamatum T622 was investigated against five phytopathogenic Fusarium species. The results showed that the fungal species, the type of EO, and concentrations play a substantial role in inhibiting the mycelial growth of Fusarium spp. GC-MS anal. of the EOs showed that the piperitone oxide and cis-piperitone oxide were found as the main components of M. longifolia. Our results also revealed that EEP possessed the growth inhibitory effect against Fusarium spp. It was observed that the extracellular secretions of T. harzianum T447 showed very high inhibition against the fungi. Our results highlighted the need for further research to apply them as a safe alternative to the chem. pesticides.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem