483-76-1 | Page 9 of 10 | Heterocyclic Building Blocks-Benzoxazole

Tavallali, Vahid’s team published research in Scientia Horticulturae (Amsterdam, Netherlands) in 2022-09-20 | CAS: 483-76-1

Modifications in Lemongrass (Cymbopogon spp.) in response to green synthesized nano-selenium complex. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

1. Trivial name: delta-Cadinene.
2. It’s mainly derived from flue-cured tobacco, burley tobacco and flavoured tobacco, it has a strong aroma and a good fixing effect, suitable for perfume, cosmetics, can also be used in wine, cigarettes, and toothpaste.
. Recommended Products is: 29350-73-0 and 51905-84-1.

Selenium nanoparticles (Se-NPs) have different applications in various technologies due to their individual properties. In order to investigate the impacts of different concentrations of a green-synthesized selenium nano-complex (0, 20, 40, 60, and 80 mg L-1) on the chem. composition, antioxidant capacity and antimicrobial activity of lemongrass essential oil (EO), an experiment was designed as a completely randomized design (CRD) with four replications. The application of 40 mg L-1 selenium nano-complex caused the highest EO yield (3.96 ¡À 0.09%). The dominant compounds in EO, geranial (44.12 ¡À 1.22%) and neral (32.53 ¡À 1.08%), were achieved by the application of 60 mg L-1 selenium nano-complex. HPLC anal. indicated that the extracts were rich in 5-o-cafeoylquinic acid, luteolin 6-c-pentosyl-8-c-pentoside, and luteolin 2-o-deoxyhexosyl-6-c-glucoside. The extracts of lemongrass plants treated with 40 and 60 mg L-1 selenium nano-complex achieved the highest amount of 5-o-cafeoylquinic acid (25.29¡À1.31 and 24.16¡À1.26 ¦Ìg mL-1, resp.). The highest antioxidant capacity was observed in the 40 mg L-1 selenium nano-complex treated plants. The min. inhibitory concentration (MIC) of EO derived from the 60 mg L-1 selenium nano-complex treated lemongrass for Salmonella typhimurium, Escherichia coli, Staphylococcus aureus, Bacillus subtilis, Aspergillus niger and Candida albicans was 0.63¡À0.03, 1.84¡À0.1, 1.05¡À0.05, 0.008¡À0.01, 0.6¡À0.01 and 0.1¡À0.01 mg mL-1, resp. It is expected that the selenium nano-complex would find a wide range of applications in medicine for its antioxidant and antimicrobial properties. It may also be applied to medicinal plants to enhance the quality and quantity of EOs.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Qin, Yu-Liang’s team published research in Food Control in 2023-03-31 | CAS: 483-76-1

The effect of volatile compounds of Syzygium aromaticum flower buds against Aspergillus flavus growth on wheat grain at postharvest stage. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Reducing the postharvest loss of cereal grains caused by deleterious fungi is critically important for the grain supply chain. Exploring antifungal constituents of plant volatile organic compounds (PVOCs) could promote the development of natural gaseous fungicides in controlling the decay of postharvest grains. In this study, PVOCs were extracted from clove (Syzygium aromaticum L.) buds and the primary constituents thereof were investigated for their effect on Aspergillus flavus growth in media postharvest grains. Fumigation with clove buds volatiles effectively inhibited A. flavus proliferation in 20% moisture wheat grains under simulated storage conditions. Gas chromatog.-mass spectrometry anal. revealed that eugenol and caryophyllene were the two main constituents of clove bud volatiles (49.80% and 36.68%, resp.). An antifungal assay demonstrated that eugenol was responsible for the antifungal activity of clove bud volatiles against A. flavus. Eugenol can completely inhibit A. flavus growth at 0.12 and 0.40 ¦ÌL/mL in vapor phase fumigation and liquid contact, resp. The proliferation of A. flavus in 20% moisture wheat grains was completely controlled after fumigation with 600 ¦ÌL/L eugenol vapor. Eugenol treatment can damage the membrane integrity of A. flavus mycelia, resulting in increased intracellular electrolyte leakage. The 38 metabolites in A. flavus hyphae exposed to 0.40 ¦ÌL/mL eugenol were markedly differentially expressed and principally involved in the biosynthesis of glycerophospholipids, linoleic acid metabolism, fatty acid metabolism, sugar metabolism, and ATP-binding cassette transporters. Eugenol also causes phosphatidylserine eversion of the plasma membrane, increased reactive oxygen species, decreased ATP production, and damaged DNA in A. flavus. We propose that eugenol treatment can disrupt cell membrane integrity, fatty acid ¦Â-oxidation, and induce apoptosis in A. flavus. This study demonstrated the potential application of clove bud volatile organic compounds as biofumigants for postharvest grain management and provided new insights into the antifungal mechanism of the main constituents against A. flavus growth.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Radzhabov, G. K.’s team published research in Pharmaceutical Chemistry Journal in 2022-08-31 | CAS: 483-76-1

Variability of the Constituent Composition of Achillea millefolium Essential Oils in the Wild Flora of Dagestan. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

The variability of the chem. composition of the aerial part of common yarrow (Achillea millefolium L.) was studied as a function of its environmental growth conditions. Samples of four populations of A. millefolium growing wild at various altitudes (1150, 1500, 1700, and 2450 m) above sea level were collected. Their essential oils were obtained by hydrodistillation followed by a determination of their chem. compositions by chromatog.-mass-spectrometry. Anal. results showed that the yield of essential oil from the plants depended on the habitat and varied from 0.06 to 0.16 mL/100 g. The composition of the essential oil of A. millefolium comprised 61 constituents, of which 47 were identified, the main group being monoterpenes and their derivatives The yield of essential oil and its composition were controlled by linear effects of several abiotic factors related to the altitude gradient.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Ouarhach, Aicha’s team published research in South African Journal of Botany in 2022-09-30 | CAS: 483-76-1

Evaluation of insecticidal activity of Lavandula coronopifolia essential oil against the Mediterranean fruit fly Ceratitis capitata Wiedemann. (Diptera: Tephritidae). Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

The present investigation was aimed to assess the toxicity of Lavandula coronopifolia (Lamiaceae) essential oil (EO) against adult Mediterranean fruit fly. Ceratitis capitata (Wiedemann) (Diptera Tephritidae) is one of the most destructive fruit pests in Morocco. Essential oil was extracted from leaves of lavender (L. coronopifolia) by hydrodistillation and analyzed by GC and GC/MS. The main compound is carvacrol (48.9%) followed by E-caryophyllene (10.8%) and caryophyllene oxide (7.7%). The EO was examined in the laboratory for 7 days to assess their activity against Ceratitis capitata (Wiedemann) (Diptera: Tephritidae) adults by ingestion toxicity. We also conducted oviposition bioassay in the laboratory, testing the oviposition deterrence of essential oils. The oil showed 75% mortality of adults at the concentration of 150¦Ìl/g after 24 h of exposure. Great differences in insect mortality were observed depending on the sex of the insects, oil concentrations and exposure time. The ingestion toxicity potential of L. coronopifolia on adults was higher (LC 50 = 86.34¦Ìl/g, LC 95 = 236.07¦Ìl/g) and also, deterred significantly the oviposition by C. capitata, reducing the number of eggs laid by about 94% compared with the controls for the concentration of 55¦Ìl/g. The results suggested that L. coronopifolia EOs may have potential as a control agent against this major stored product insect.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Mouhoub, Anouar’s team published research in World Journal of Microbiology & Biotechnology in 2022-10-31 | CAS: 483-76-1

Assessment of the antioxidant, antimicrobial and antibiofilm activities of essential oils for potential application of active chitosan films in food preservation. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

In the food industry, the development of microbial biofilms is a serious problem that leads to the contamination and deterioration of food products. To overcome that, our aim consists of searching for natural antimicrobial and non-toxic compounds (essential oils EOs), which might be used alone or adsorbed on natural biopolymer films (chitosan). In this work, the antioxidant activity of eight EOs was evaluated by DPPH radical-scavenging method while their antibacterial activity was determined by diffusion on agar and microdilution methods. Among all tested EOs, Eugenia caryophyllus, Cinnamomum zeylanicum Blume and Thymus satureioides Cosson showed high antioxidant activities at the concentration of 25.6 mg/mL, with resp. values of (86.26%, 81.75%, and 76%), and strong antibacterial activity against Pseudomonas aeruginosa, Escherichia coli, Staphylococcus aureus, and Enterococcus hirae, with (MIC) values ¡Ü 4¦ÌL/mL. At the concentration of 1¦ÌL/mL, these EOs tested alone, showed values of antibiofilm-forming activity ranging from 79.43 to 99.33% and from 44.18 to 94.17%, when they are adsorbed onto chitosan film. These promising results confirm that these three EOs have a good potential for an eventual application in the food industry, as antimicrobial and antioxidant agents, or as active biodegradable food packaging, if combined with chitosan.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Ibdah, Mwafaq’s team published research in Phytochemistry (Elsevier) in 2022-10-31 | CAS: 483-76-1

Identification and characterization of three nearly identical linalool/nerolidol synthase from Acorus calamus. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Acorus calamus is a perennial aromatic medicinal plant from the Acorusaceae family, known for its pharmaceutical and medicinal value. A combined chem., biochem., and mol. study was conducted to evaluate the differential accumulation of volatile organic compounds (VOCs) in rhizomes and leaves of A. calamus essential oil. Here, we performed VOC profiling and transcriptome-based identification and functional characterization of terpene synthase (TPS) genes. A total of 110 VOCs were detected from the rhizomes and leaves of A. calamus, and some VOCs showed significant differences between them. The further transcriptome-based anal. led to the identification of six putative TPSs genes. In phylogenetic anal., three TPSs belonged to the TPS-g clade, one to each of the TPS-a, TPS-c, and TPS-e clades. The heterologous E. coli-based expression of recombinant TPSs identified three genes (AcTPS3, AcTPS4, and AcTPS5) as bifunctional linalool/nerolidol synthase. The correlation of TPS gene expression and VOC metabolite profiles supported the function of these genes in A. calamus. Our findings provide a roadmap for future efforts to enhance the mol. mechanisms of terpene biosynthesis and our understanding of Acorus-insect interactions.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Emami, Shabnam’s team published research in Biologia (Cham, Switzerland) in 2022-10-31 | CAS: 483-76-1

Cinnamon extract and its essential oil nanoliposomes – preparation, characterization and bactericidal activity assessment. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

The cinnamon essential oil and extract nanoliposomes were prepared through thin layer hydration-ultrasonication technique, using lecithin and three different co-surfactants namely, glycerol, triacetin and propylene glycol, and Tween 80 as surfactant. Results showed that the propylene glycol led to production of the nanoliposomes with the smallest mean particle size (92.03 nm) with spherical-shaped and the greatest net-zeta potential value (-24.1 mV) and was selected as more suitable co-surfactant. While, all prepared nanoliposomes had DPPH radical scavenging activities, the antioxidant activity of cinnamon extract nanoliposome was the greatest (78 ¡À 5%). Different amounts of cinnamon essential oil (0.25, 0.5 and 1.25 mL) were selected to prepared cinnamon essential oil nanoliposomes using propylene glycol and their antioxidant and antibacterial activities were evaluated. A good correlation was observed between amounts of cinnamon essential oil of nanoliposomes and their antioxidant activities (R2 = 0.9945). Although antibacterial activity of cinnamon essential oil and extract were greater than those were encapsulated into nanoliposomes, both cinnamon essential oil and extract nanoliposomes exhibited high antibacterial activities against Escherichia coli and Listeria monocytogenes bacteria strains. Results indicated that based on the min. inhibitory and bactericidal concentrations of the prepared samples, L. monocytogenes had higher resistance to the prepared cinnamon nanoliposomes.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Burin, G. R. M.’s team published research in Journal of Supercritical Fluids in 2022-07-31 | CAS: 483-76-1

Innovative formulations of PCL: Pluronic monoliths with copaiba oleoresin using supercritical CO2 foaming/mixing to control Aedes aegypti. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Copaiba oleoresin (Co), a promising bioactive agent to control Aedes aegypti proliferation, was incorporated by supercritical carbon dioxide (scCO2) foaming/mixing method (SFM) in two types of poly(¦Å-caprolactone) (PCL), PCL45 and PCL50, using Pluronic F-68 (Plu) as a surfactant and porogenic agent. The SFM was performed at 35¡ãC, scCO2 densities of 750 and 850 kg m-3, soaking time of 2.5 h, and depressurization rate of 5 bar min-1. The physicochem. characterization of monoliths, the in vitro release, and larvicidal activity against A. aegypti larvae were evaluated. All monoliths with copaiba oleoresin presented larvicidal effects. The best results were observed for PCL45:Plu:Co (56:3:41) monoliths at 750 and 850 kg m-3. This result can be attributed to the higher hydrophobicity of PCL45 than PCL50. These findings indicate that copaiba oleoresin-loaded PCL:Plu:Co monoliths are innovative and sustainable materials capable of controlling the proliferation of A. aegypti larvae and insects to avoid mosquito-borne diseases.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Johnson, Joel B.’s team published research in Spectrochimica Acta, Part A: Molecular and Biomolecular Spectroscopy in 2022-12-15 | CAS: 483-76-1

Mid-infrared spectroscopy for the rapid quantification of eucalyptus oil adulteration in Australian tea tree oil (Melaleuca alternifolia). Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Essential oil distilled from Melaleuca alternifolia leaves, commonly known as tea tree oil, is well known for its biol. activity, principally its antimicrobial properties. However, many samples are adulterated with other, cheaper essential oils such as eucalyptus oil. Current methods of detecting such adulteration are costly and time-consuming, making them unsuitable for rapid authentication screening. This study investigated the use of mid-IR (MIR) spectroscopy for detecting and quantifying the level of eucalyptus oil adulteration in spiked samples of pure Australian tea tree oil. To confirm the authenticity of the tea tree oil samples, GC-MS anal. was used to profile 37 of the main volatile constituents present, demonstrating that the samples conformed to ISO specifications. Three chemometric regression techniques (PLSR, PCR and SVR) were trialled on the MIR spectra, along with a variety of pre-processing techniques. The best-performing full-wavelength PLSR model showed excellent prediction of eucalyptus oil content, with an R2CV of 0.999 and RMSECV of 1.08% volume/volume The RMSECV could be further improved to 0.82% volume/volume through a moving window wavenumber optimization process. The results suggest that MIR spectroscopy combined with PLSR can be used to predict eucalyptus oil adulteration in Australian tea tree oil samples with a high level of accuracy.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Ivic, Jelena’s team published research in Advanced Sustainable Systems in 2022-10-31 | CAS: 483-76-1

Pinaceae Fir Resins as Natural Dielectrics for Low Voltage Operating, Hysteresis-Free Organic Field Effect Transistors. Recommended basis is Cadinene. Products is: https://www.ambeed.com/products/189165-77-3.html, 51905-84-1

Natural dielecs. are emerging nowadays as a niche selection of materials for applications targeting biocompatibility and biodegradability for electronics and sensors within the overall effort of scientific community to achieve sustainable development and to build environmental consciousness. The two natural resins analyzed in this study, silver fir and Rocky mountain fir demonstrate robust dielec. properties and excellent film forming capabilities, while being trap free dielecs. in high-performance organic field effect transistors (OFETs) operating at voltages as low as 1 V. Immense research possibilities are demonstrated through the avenue of inorganic nanofillers insertions in the natural resins film, that opens the door for fabrication of very low voltage OFETs with high dielec. constant insulating layers.

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem