Category: 5676-58-4

Synthesis of Benzoxazoles from 2-Aminophenols and β-Diketones Using a Combined Catalyst of Bronsted Acid and Copper Iodide was written by Mayo, Muhammad Shareef;Yu, Xiaoqiang;Zhou, Xiaoyu;Feng, Xiujuan;Yamamoto, Yoshinori;Bao, Ming. And the article was included in Journal of Organic Chemistry in 2014.COA of Formula: C9H9NO This article mentions the following:

Cyclization reactions of 2-aminophenols with β-diketones catalyzed by a combination of Bronsted acid and CuI are presented. Various 2-substituted benzoxazoles were obtained through these reactions. Different substituents such as Me, chloro, bromo, nitro, and methoxy on 2-aminophenol are tolerated under the optimized reaction conditions. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4COA of Formula: C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.COA of Formula: C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

A divergent and selective synthesis of isomeric benzoxazoles from a single N-Cl imine was written by Chen, Cheng-yi;Andreani, Teresa;Li, Hongmei. And the article was included in Organic Letters in 2011.Application In Synthesis of 2,5-Dimethylbenzoxazole This article mentions the following:

A divergent and regioselective synthesis of either 3-substituted benzoisoxazoles or 2-substituted benzoxazoles from readily accessible ortho-hydroxyaryl N-H ketimines is described. The reaction proceeds in two distinct pathways through a common N-Cl imine intermediate: (a) N-O bond formation to form benzoisoxazole under anhydrous conditions and (b) NaOCl mediated Beckmann-type rearrangement to form benzoxazole, resp. The reaction path also depends on the electronic nature of the aromatic ring, with the electron-rich aromatic rings favoring the rearrangement and the electron-deficient rings favoring the N-O bond formation. A Beckmann-type rearrangement mechanism via net [1,2]-aryl migration for the formation of 2-substituted benzoxazole is proposed. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Application In Synthesis of 2,5-Dimethylbenzoxazole).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have gained a lot of importance in the past few years because of their use in intermediates for the preparation of new biological materials. In the past years, numerous benzoxazole derivatives have been synthesised and evaluated for their biological potential.Application In Synthesis of 2,5-Dimethylbenzoxazole

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Mass spectra of some dialkylbenzoxazoles and 1,2-benzisoxazoles was written by Lozynski, Marek;Krzyzanowska, Ewa;Matecka, Dorota. And the article was included in Polish Journal of Chemistry in 1990.Electric Literature of C9H9NO This article mentions the following:

The mass spectra of several 3,5-dialkyl-1,2-benzisoxazoles and isomeric 2,5-dialkylbenzoxazoles have been measured. The fragmentation of di-Me derivatives has been considered to proceed via an iso-π-electronic structure with the azulene ion, taking into account that the cleavage of the N-O linkage followed by carbon monoxide expulsion is prefered. For all 5-alkyl isomers, rupture of the benzylic C-C bond is predominant. If a long alkyl substituent is present in the heterocyclic ring, intensive peaks due to the McLafferty rearrangement as well as to γ-cleavage are observed Fragmentation of compounds containing an aliphatic chain in different positions in relation to nitrogen gives the possibility of determining the structure of the heterocyclic ring. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Electric Literature of C9H9NO).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. Benzoxazole derivatives have different biological activities. Due to its versatile biological properties, benzoxazole has been incorporated as an essential pharmacophore and substructure in many medicinal compounds.Electric Literature of C9H9NO

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Thermal Degradation Studies of Glucose/Glycine Melanoidins was written by Tehrani, Kourosch Abbaspour;Kersiene, Milda;Adams, An;Venskutonis, Rimantas;De Kimpe, Norbert. And the article was included in Journal of Agricultural and Food Chemistry in 2002.Application of 5676-58-4 This article mentions the following:

Nondialyzable and water-insoluble melanoidins, isolated from a glucose/glycine model reaction mixture, which was prepared in a standardized way according to the guidelines of the COST Action 919, were heated at different temperatures ranging from 100 to 300 °C. Among the volatile compounds, which were analyzed by solid-phase microextraction and GC-MS, pyrazines, pyridines, pyrroles, and furans were detected. In general, total amounts of volatile compounds increased with the temperature When water-insoluble melanoidins were heated, especially at higher temperatures, this resulted in a higher diversity of isolated compounds For furans, pyrroles, pyrazines, and carbonyl compounds, a maximum was observed in the case of high mol. weight melanoidins around 200-220 °C. Pyridines and total oxazoles, however, were generated in higher yields with increasing temperatures Thus, the possibility of producing some flavor-significant volatiles from heated standard melanoidins at temperatures relevant to food preparation and contribute to the flavor aspects originating from melanoidins. In the experiment, the researchers used many compounds, for example, 2,5-Dimethylbenzoxazole (cas: 5676-58-4Application of 5676-58-4).

2,5-Dimethylbenzoxazole (cas: 5676-58-4) belongs to benzoxazole derivatives. The benzoxazole moiety is widely found in various natural compounds, which are often found to be biologically active. Benzoxazoles are prominent in medicinal chemistry due to their wide spectrum of pharmacological activities such as antibacterial, antifungal, anticancer.Application of 5676-58-4

Referemce:
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem