Discovery of 2-Methylbenzo[d]oxazol-6-amine

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5676-60-8, Name is 2-Methylbenzo[d]oxazol-6-amine, belongs to benzoxazole compound, is a common compound. Formula: C8H8N2OIn an article, once mentioned the new application about 5676-60-8.

Gould-jacobs reaction of 5- and 6-amino-2-substituted benzoxazoles. II. Reaction with 3-ethoxymethylene-2,4-pentanedione and ethyl 2-ethoxymethylene-3-oxobutanoate

Nucleophilic reaction of 5-amino- and 6-amino-2-substituted benzoxazoles 1 and 2 with 3-ethoxymethylene-2,4-pentanedione (3) gave compounds 5 and 6. Compounds 1 and 2 reacted with ethyl ethoxymethylene-3-oxobutanoate (4) under formation of compounds 7 and 8. The substitution products 7 and 8 underwent thermal cyclization at high temperature (boiling mixture of diphenyl ether and biphenyl) to give angularly and linearly annelated derivatives of 5-acetyl-4-oxo-oxazolo[4,5-f]-quinoline 9 and 7-acetyl-8-oxo-oxazolo[5,4-g]quinoline 10 (from 7), and derivatives of 8-acetyl-9-oxo-oxazolo[5,4-f]quinoline 11 and 6-acetyl-5-oxo-oxazolo[4,5-g]quinoline 12 (from 8). The structure of the substitution products is discussed on the basis of their spectral characteristics (1H and 13C NMR, IR, UV, MS).

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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NEW GPR119MODULATORS

The application relates to compounds of Formula (Ia): and pharmaceutically acceptable salts, solvates, hydrates, geometrical isomers, tautomers, optical isomersor N-oxides thereof. The application also relates to pharmaceutical compositions comprising these compounds and to the use of these compounds for the prophylaxis and treatment of medical conditions relating to disorders of the G-protein- coupled receptor GPR119, such as diabetes, obesity and osteoporosis.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. Computed Properties of C8H8N2O, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 5676-60-8, in my other articles.

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Synthesis of 9,10-distyrylanthracene derivative and its one- and two-photon induced emission in solid state

Solid fluorescence plays an important role in optoelectronic devices. In this paper, 9,10-bis(6-dimethylamino benzoxazole styryl)-anthracene (1) was synthesized. 1 displayed a strong emission in solid state (microcrystalline state, amorphous solid state and polymeric thin film) resulted from aggregation-induced emission mechanism, and a large absolute fluorescence quantum yield (?f = 0.65) was obtained. 1 also exhibited up-conversion emission in solid state and a strong yellow emission was observed upon excitation with 800?1064 nm, the quadratic dependence of the fluorescence on the excitation laser intensity confirmed that the up-conversion emission resulted from two-photon process.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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Acetamide and substituted acetamide-containing thiourea inhibitors of herpes viruses

Compounds of the formula: are useful in the treatment of diseases associated with herpes viruses including human cytomegalovirus, herpes simplex viruses, Epstein-Barr virus, varicella-zoster virus, human herpesviruses-6 and -7, and Kaposi herpesvirus.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Extracurricular laboratory:new discovery of 2-Methylbenzo[d]oxazol-6-amine

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Structure-activity relationship of human glutaminyl cyclase inhibitors having an N-(5-methyl-1H-imidazol-1-yl)propyl thiourea template

In an effort to design inhibitors of human glutaminyl cyclase (QC), we have synthesized a library of N-aryl N-(5-methyl-1H-imidazol-1-yl)propyl thioureas and investigated the contribution of the aryl region of these compounds to their structure-activity relationships as cyclase inhibitors. Our design was guided by the proposed binding mode of the preferred substrate for the cyclase. In this series, compound 52 was identified as the most potent QC inhibitor with an IC50 value of 58 nM, which was two-fold more potent than the previously reported lead 2. Compound 52 is a most promising candidate for future evaluation to monitor its ability to reduce the formation of pGlu-Abeta and Abeta plaques in cells and transgenic animals.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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NMR recognition studies of C¡¤G base pairs by new easily accessible heterobicyclic systems

Recognition of DNA duplexes by triplex forming oligonucleotides (TFO) is limited to DNA homopurine sequences. As a first step to overcome this limitation we report here NMR recognition studies of the C¡¤G base pair by new heterocyclic systems, derived from benzimidazole and benzoxazole units bearing an urea donor moiety, designed to bound to the 4-amino group of the cytosine and the O4- and N7-atoms of the guanosine bases, respectively.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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Gould-Jacobs reaction of 5- and 6-amino-2-substituted benzoxazoles. III. Reaction with 3-ethoxy-2-cyanopropeno-nitrile and ethyl 3-ethoxy-2-cyanopropenoate

Nucleophilic reaction of 5-amino-(1) and 6-amino-2-substituted benzoxazoles (2) with 3-ethoxy-2-cyanopropenonitrile (3) afforded the respective benzoxazolylaminomethylenemalononitriles 5 and 6. The amino derivatives 1 and 2 reacted with ethyl 3-ethoxy-2-cyanopropenoate (4) to give the corresponding esters of benzoxazolylamino-2-cyanopropenoic acid 7 and 8, respectively. The products 7 on thermal cyclization at 250-260C in a mixture of diphenyl ether and biphenyl afforded a mixture of angularly and linearly annelated 5-nitrile-4-oxooxazolo[4,5-f]quinoline 9 and 7-nitrile-8-oxooxazolo[5,4-g]quinoline 10; under the same conditions compounds 8 were converted into 8-nitrile-9-oxooxazolo[5,4-f]quinolines 11 and 6-nitrile-5-oxooxazolo[4,5-g]quinolines 12.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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Iron-catalysed, general and operationally simple formal hydrogenation using Fe(OTf)3 and NaBH4

An operationally simple and environmentally benign formal hydrogenation protocol has been developed using highly abundant iron(iii) salts and an inexpensive, bench stable, stoichiometric reductant, NaBH4, in ethanol, under ambient conditions. This reaction has been applied to the reduction of terminal alkenes (22 examples, up to 95% yield) and nitro-groups (26 examples, up to 95% yield). Deuterium labelling studies indicate that this reaction proceeds via an ionic rather than radical mechanism.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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PYRIMIDINE DERIVATIVES

A compound of the following formula: wherein R1, R2, R3, R4, R5,T, U, V, X, Y, Z, G, and Z are defined herein. It also discloses a method of treating an angiogenesis-related disorder, e.g., cancer or age-related macular degeneration, with such a compound.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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In homogeneous catalysis, the catalyst is in the same phase as the reactant. The number of collisions between reactants and catalyst is at a maximum.In a patent, 5676-60-8, name is 2-Methylbenzo[d]oxazol-6-amine, introducing its new discovery. COA of Formula: C8H8N2O

NOVEL NICOTINAMIDE DERIVATIVES OR SALTS THEREOF

no abstract published

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Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem