5676-60-8, Name is 2-Methylbenzo[d]oxazol-6-amine, belongs to benzoxazole compound, is a common compound. Formula: C8H8N2OIn an article, once mentioned the new application about 5676-60-8.
Gould-jacobs reaction of 5- and 6-amino-2-substituted benzoxazoles. II. Reaction with 3-ethoxymethylene-2,4-pentanedione and ethyl 2-ethoxymethylene-3-oxobutanoate
Nucleophilic reaction of 5-amino- and 6-amino-2-substituted benzoxazoles 1 and 2 with 3-ethoxymethylene-2,4-pentanedione (3) gave compounds 5 and 6. Compounds 1 and 2 reacted with ethyl ethoxymethylene-3-oxobutanoate (4) under formation of compounds 7 and 8. The substitution products 7 and 8 underwent thermal cyclization at high temperature (boiling mixture of diphenyl ether and biphenyl) to give angularly and linearly annelated derivatives of 5-acetyl-4-oxo-oxazolo[4,5-f]-quinoline 9 and 7-acetyl-8-oxo-oxazolo[5,4-g]quinoline 10 (from 7), and derivatives of 8-acetyl-9-oxo-oxazolo[5,4-f]quinoline 11 and 6-acetyl-5-oxo-oxazolo[4,5-g]quinoline 12 (from 8). The structure of the substitution products is discussed on the basis of their spectral characteristics (1H and 13C NMR, IR, UV, MS).
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Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem