Category: 59-49-4

Analyzing the synthesis route of 59-49-4

59-49-4 2-Benzoxazolinone 6043, abenzoxazole compound, is more and more widely used in various fields.

59-49-4, 2-Benzoxazolinone is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

Mix 1514.2kg of 99.3% pure 2-benzoxazolone (VI) with 4500 kg of methanol, add 1295.7kg of sodium iodide, 3000kg of sulfuric acid, mix, heat up to 34-38 degrees, add 960.9kg mass fraction 30% hydrogen peroxide was added dropwise, and the reaction was completed until 2841.3 kg of 6-iodo-2-benzimidazolone (VIII) having a purity of 99.2% was obtained in a yield of 97.03%., 59-49-4

59-49-4 2-Benzoxazolinone 6043, abenzoxazole compound, is more and more widely used in various fields.

Reference£º
Patent; Shao Yutian; (12 pag.)CN110156712; (2019); A;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Simple exploration of 59-49-4

As the paragraph descriping shows that 59-49-4 is playing an increasingly important role.

With the rapid development and complex challenges of chemical substances, new drug synthesis pathways are usually the most effective.59-49-4,2-Benzoxazolinone,as a common compound, the synthetic route is as follows.

Ar gas protection, Ice bath conditions, NaH (910 mg, 47.9 mmol) was added to dry THF and benzoxetine was added (3.6 g, 26.6 mmol) Dissolved in anhydrous THF, Methyl iodide (5.7 g, 40 mmol) was slowly added, Reaction to ice bath to room temperature overnight reaction. After the reaction was stopped, the mixture was concentrated, diluted with water, extracted with DCM, dried and separated on a light reddish brown solid (2.8 g, 71%), 59-49-4

As the paragraph descriping shows that 59-49-4 is playing an increasingly important role.

Reference£º
Patent; Chinese Academy Of Medical Sciences Pharmaceutical Institute; Xu Boling; Shen Zhufang; Bie Jianbo; Mu Yongzhao; Chen Hualong; Liu Lvnan; Zhou Jie; Li Caina; Cao Ran; Huan Yi; Sun Shujuan; (258 pag.)CN107098846; (2017); A;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Introduction of a new synthetic route about 59-49-4

With the rapid development of chemical substances, we look forward to future research findings about 59-49-4

2-Benzoxazolinone, cas is 59-49-4, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,59-49-4

To a mixture of 3H-benzooxazol-2-one (20 g, 0.15 mol) in DCM (500 mL) was added bromine (8.34 mL, 0.16 mol). After stirring at room temperature for 19.5 h, the orange precipitate that had formed was filtered off and washed with DCM until the orange color was washed out. The filtrate was concentrated to approximately 33% of its original volume and filtered and washed as before. The combined solids weighed 28.36 g and contained ca. 8-9% starting material.

With the rapid development of chemical substances, we look forward to future research findings about 59-49-4

Reference£º
Patent; AVENTIS PHARMACEUTICALS INC.; WO2006/86705; (2006); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Introduction of a new synthetic route about 59-49-4

With the rapid development of chemical substances, we look forward to future research findings about 59-49-4

2-Benzoxazolinone, cas is 59-49-4, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,59-49-4

The reaction mixture was purified directly by silica gel column chromatography (ethyl acetate: hexane =1:1) to obtain a pale red solid product. Yield 108 mg (99%).

With the rapid development of chemical substances, we look forward to future research findings about 59-49-4

Reference£º
Patent; Kyushu University, National University Corporation; OHSHIMA Takashi; MORIMOTO Hiroyuki; SHIMIZU Yuhei; EP2821389; (2015); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Introduction of a new synthetic route about 59-49-4

With the rapid development of chemical substances, we look forward to future research findings about 59-49-4

2-Benzoxazolinone, cas is 59-49-4, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,59-49-4

40.0 g (0.30 mol) of 2-benzoxazolinone were dissolved with stirring at room temperature in 600.0 ml (0.30 mole) of 68% nitric acid. It was then heated to 50 C. and stirred at this temperature for three hours. The reaction was stirred for a further 16 h at room temperature. After completion of the reaction, the mixture was poured into about 2.0 l of ice water, precipitated substance was filtered off, washed neutral and dried. After drying, 6-nitro-3H-1,3-benzoxazol-2-one (39.1 g, 72%) was obtained as a pale yellow solid. 1H-NMR (300 MHz, d6-DMSO): delta=7.25 (d, 1H, 4-H), 8.10 (d, 1H, 5-H), 8.17 (s, 1H, 7-H), 12.43 (br s, 1H, NH).

With the rapid development of chemical substances, we look forward to future research findings about 59-49-4

Reference£º
Patent; Henkel AG & Co. KGaA; Gebert-Schwarzwaelder, Antje; Nemitz, Ralph; Kroos, Astrid; Koenen, Annika; (20 pag.)US2019/167551; (2019); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Application of Tris[2-(dimethylamino)ethyl]amine

As the rapid development of chemical substances, we look forward to future research findings about 59-49-4

The benzoxazole compound, cas is 59-49-4 name is 2-Benzoxazolinone, mainly used in chemical industry, its synthesis route is as follows.,59-49-4

Example 251A 6-bromo-1,3-benzoxazol-2(3H)-one A mixture of 2-benzoxazolinone (3.00 g, 22.2 mmol), 1,3-dibromo-5,5-dimethylhydantoin (3.49 g, 12.2 mmol), and trifluoromethanesulfonic acid (5.00 g, 33.3 mmol) in dichloromethane (100 mL) at room temperature was protected from light, stirred for 1 hour, and concentrated. The concentrate was purified by flash column chromatography on silica gel with 50% ethyl acetate/hexanes to provide the desired product.

As the rapid development of chemical substances, we look forward to future research findings about 59-49-4

Reference£º
Patent; Augeri, David J.; Baumeister, Steven A.; Bruncko, Milan; Dickman, Daniel A.; Ding, Hong; Dinges, Jurgen; Fesik, Stephen W.; Hajduk, Philip J.; Kunzer, Aaron R.; McClellan, William; Nettesheim, David G.; Oost, Thorsten; Petros, Andrew M.; Rosenberg, Saul H.; Shen, Wang; Thomas, Sheela A.; Wang, Xilu; Wendt, Michael D.; US2002/86887; (2002); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Analyzing the synthesis route of 59-49-4

With the synthetic route has been constantly updated, we look forward to future research findings about 2-Benzoxazolinone,belong benzoxazole compound

As a common heterocyclic compound, it belong benzoxazole compound,2-Benzoxazolinone,59-49-4,Molecular formula: C7H5NO2,mainly used in chemical industry, its synthesis route is as follows.,59-49-4

General procedure: Nitric acid (68%, 5.30 cm3, 80 mmol) cooled to 0-5Cwas added dropwise to a solution of benzoxazolinone (10 mmol) in 20 cm3 of acetic anhydride. The mixture was stirred at 0-5C for 3 h. The precipitate was filtered, washed with cold H2O, dried, and recrystallized from suitable solvent to afford the corresponding nitrobenzoxazolones compounds 3a (67.77%) and 3b (91%).

With the synthetic route has been constantly updated, we look forward to future research findings about 2-Benzoxazolinone,belong benzoxazole compound

Reference£º
Article; Yahia, Wassila; Nacereddine, Abdelmalek Khorief; Seddiki, Khemissi; Liacha, Messaoud; Nippert; Revue Roumaine de Chimie; vol. 60; 9; (2015); p. 853 – 859;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Downstream synthetic route of 2-Benzoxazolinone

With the synthetic route has been constantly updated, we look forward to future research findings about 2-Benzoxazolinone,belong benzoxazole compound

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO481,mainly used in chemical industry, its synthesis route is as follows.,59-49-4

To a mixture of 3H-benzooxazol-2-one (20 g, 0.15 mol) in DCM (500 mL) was added bromine (8.34 mL, 0.16 mol). After stirring at room temperature for 19.5 h, the orange precipitate that had formed was filtered off and washed with DCM until the orange color was washed out. The filtrate was concentrated to approximately 33% of its original volume and filtered and washed as before. The combined solids weighed 28.36 g. 1H NMR indicated the product was clean albeit contained ca. 8-9% starting material meaning the true yield of product was 26.72 g, 84%.

With the synthetic route has been constantly updated, we look forward to future research findings about 2-Benzoxazolinone,belong benzoxazole compound

Reference£º
Patent; AVENTIS PHARMACEUTICALS INC.; US2008/138413; (2008); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

New learning discoveries about 59-49-4

With the synthetic route has been constantly updated, we look forward to future research findings about 2-Benzoxazolinone,belong benzoxazole compound

2-Benzoxazolinone, cas is 59-49-4, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,59-49-4

Intermediate 33: Synthesis of 3-methyl-2-oxo-2,3-dihydrobenzo[d]oxazole-6-sulfonyl chloride.1. Synthesis of 3-methylbenzo|”d”|oxazol-2 (3H)-one.Sodium hydride (7.00 mmol) was added to a chilled (0 0C) solution of benzo[d]oxazol- 2(3H)-one (4.81 mmol) in tetrahydrofuran (20 mL) and the reaction mixture was maintained for 30 min. Methyl iodide (7.25 mmol) was added dropwise and the reaction mixture was maintained for 6 h at it. The reaction mixture was diluted with with ethanol (10 mL) and the mixture was concentrated. The residue was diluted with water (50 mL) and was extracted with dichloromethane (3 x 20 mL). The combined organic layers were dried (sodium sulfate), filtered and concentrated to afford 3-methylbenzo[d]oxazol-2 (3H)-one in 82% yield as a light red solid.

With the synthetic route has been constantly updated, we look forward to future research findings about 2-Benzoxazolinone,belong benzoxazole compound

Reference£º
Patent; MEMORY PHARMACEUTICALS CORPORATION; DANCA, Mihaela, Diana; DUNN, Robert; TEHIM, Ashok; XIE, Wenge; WO2010/21797; (2010); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

New learning discoveries about 59-49-4

The synthetic route of 59-49-4 has been constantly updated, and we look forward to future research findings.

59-49-4, 2-Benzoxazolinone is a benzoxazole compound, ?involved in a variety of chemical synthesis. Rlated chemical reaction is continuously updated

6-chloro-3-methylbenzo[d]oxazol-2(3H)-one (S8). 60% sodium hydride (1.44 g, 36 mmol) wasadded to a solution of benzoxindolidinone (3.38 g, 25 mmol) in THF (20 mL) at 0 C, and stirredat 0 C for 30 minutes. Iodomethane (2.30 mL, 37.5 mmol) was added dropwise and stirred at room temperature for 9 hours. The reaction mixture was diluted with ethanol and concentrated.The residue was diluted with water and extracted with dichloromethane. The organic layers werecombined, dried over sodium sulfate, filtered, and concentrated. The product was purified bycolumn chromatography eluting with 25% ethyl acetate/hexanes to yield S8 (1.62 g, 43%) as anoff white solid.Rf: 0.25 (25% ethyl acetate/hexanes)1H NMR (400 MHz, CDCl3): delta = 7.22 – 7.17 (m, 2H), 7.15 – 7.09 (m, 1H), 6.98 – 6.95 (m, 1H),3.41 (s, 3H)13C NMR (101 MHz, CDCl3): delta = 154.9, 142.8, 131.9, 124.0, 122.6, 110.1, 108.2, 28.2

The synthetic route of 59-49-4 has been constantly updated, and we look forward to future research findings.

Reference£º
Article; Fosu, Stacy C.; Hambira, Chido M.; Chen, Andrew D.; Fuchs, James R.; Nagib, David A.; Chem; vol. 5; 2; (2019); p. 417 – 428;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem