Category: 701-16-6

One of the major reasons for studying chemical kinetics is to use measurements of the macroscopic properties of a system, name: 5-Fluoro-2-methylbenzo[d]oxazole, such as the rate of change in the concentration of reactants or products with time.In a article, mentioned the application of 701-16-6, Name is 5-Fluoro-2-methylbenzo[d]oxazole, molecular formula is C8H6FNO

Compounds and synthesis process

Disclosed is a process for preparing a 6-chloro-2,5-dicarbonamido phenol compounds comprising a step employing a 2-alkyl-6-aminobenzoxazole to form a 2-alkyl-6-amino-7-chlorobenzoxazole in which the 2-alkyl group is unbranched at the alpha carbon. It also provides intermediate compounds useful in the process. The process provides a simple and safe way to prepare 6-chloro-2,5-dicarbonamido phenol compounds in good yield.

Sometimes chemists are able to propose two or more mechanisms that are consistent with the available data. name: 5-Fluoro-2-methylbenzo[d]oxazole, If a proposed mechanism predicts the wrong experimental rate law, however, the mechanism must be incorrect.Welcome to check out more blogs about 701-16-6, in my other articles.

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Related Products of 701-16-6, The reaction rate of a catalyzed reaction is faster than the reaction rate of the uncatalyzed reaction at the same temperature.701-16-6, Name is 5-Fluoro-2-methylbenzo[d]oxazole, molecular formula is C8H6FNO. In a Patent£¬once mentioned of 701-16-6

BENZOTHIADIAZINE COMPOUNDS

The invention is directed to substituted benzothiadiazine derivatives. Specifically, the invention is directed to compounds according to Formula (I):wherein R, R1, R2, R3, R4 and R5 are as defined herein. The compounds of the invention are inhibitors of CD73 and can be useful in the treatment of cancer, pre-cancerous syndromes and diseases associated with CD73 inhibition, such as AIDS, autoimmune diseases, infections, atherosclerosis, and ischemia-reperfusion injury. Accordingly, the invention is further directed to pharmaceutical compositions comprising a compound of the invention. The invention is still further directed to methods of inhibiting CD73 activity and treatment of disorders associated therewith using a compound of the invention or a pharmaceutical composition comprising a compound of the invention.

We¡¯ll also look at important developments in the pharmaceutical industry because understanding organic chemistry is important in understanding health, medicine, the role of 701-16-6, and how the biochemistry of the body works.Related Products of 701-16-6

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

701-16-6, Chemistry is traditionally divided into organic and inorganic chemistry. The former is the study of compounds containing at least one carbon-hydrogen bonds.In a patent£¬Which mentioned a new discovery about 701-16-6

FLUORO-SUBSTITUTED BENZOXAZOLE POLYMETHINE DYES

Disclosed are reactive polyfluoro benzoxazole polymethine dyes that are useful for labelling and detecting biological and other materials. The dyes are of formula (I): in which X is selected from the group consisting of -O-, -S- and at least one of groups R1 and R2 is the group -L-Rx or -L-Rp, where L is a linking group, Rx is a group suitable for covalent attachment of the dye to a component and Rp is a component; and at least one of groups R3, R4, R5, R6, R7, R8, R9 and R10 comprises fluorine. The use of polymethine dyes substituted by fluorine and having additional substitution by sulphonic acid groups, for labelling biological target molecules results in a labelled product in which there is reduced dye-dye aggregation and improved photostability, compared with cyanine dyes having no such substitutions.

One of the oldest and most widely used commercial enzyme inhibitors is aspirin, 701-16-6, which selectively inhibits one of the enzymes involved in the synthesis of molecules that trigger inflammation. you can also check out more blogs about 701-16-6

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

701-16-6, A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 701-16-6, Name is 5-Fluoro-2-methylbenzo[d]oxazole, molecular formula is C8H6FNO. In a Article, authors is Paulechka, Eugene£¬once mentioned of 701-16-6

Critical Evaluation of the Enthalpies of Formation for Fluorinated Compounds Using Experimental Data and High-Level Ab Initio Calculations

The ab initio method for the prediction of the enthalpies of formation for CHON-containing organic compounds proposed earlier (Paulechka, E.; Kazakov, A. J. Chem. Theory Comput. 2018, 14, 5920-5932) has been extended to their fluorinated derivatives. A single experimental DeltafHm is typically available for compounds in this scope. Thus, a priori evaluation of the data quality was found to be inefficient despite all available experimental data for C1-C3 hydrofluorocarbons and 34 data points for medium-sized organofluorine compounds being considered. The training set was derived by analyzing the consistency of the experimental and predicted values and the removal of outliers. Significant issues with the experimental data, including inconsistency across different laboratories, were identified, and potential causes for these problems were discussed. A conservative estimate of uncertainty for the experimental DeltafHm of organofluorine compounds was proposed.

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.701-16-6. In my other articles, you can also check out more blogs about 701-16-6

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Name is 5-Fluoro-2-methylbenzo[d]oxazole, as a common heterocyclic compound, it belongs to benzoxazole compound, and cas is 701-16-6, its synthesis route is as follows.,701-16-6

[0436] Compound 50: To a solution of Comp-50c (3.95 g, 26.15 mmol) in THF:iBuOH (50 mL 4: 1 ) was added t-BuOK (8.78 g, 78.47 mmol) and the reaction mixture was stirred for 10 min. Comp-3b (5.18 g, 23.54 mmol) was added portion wise and the reaction mixture was stirred at room temperature for 16h. Progress of the reaction was monitored by TLC and LCMS. After completion, the reaction mixture was quenched with H20 and extracted with EtOAc. The organic layer was washed with brine, separated, dried over anhydrous Na2SO4 and concentrated in vacuo. The crude obtained was purified by column chromatography (silica, 100-200 mesh, 2-3% MeOH in ethyl acetate) to afford (E)-2-(2-(2,5-dimethyl-l-(l- me1hylpiperidin-4-yl)-lH-pyrrol-3-y])viny])-5-fluorobenzo[d]oxazole (50; 1.8 g, 20%) as yellow solid. (0756) [0437] HPLC Purity: 98.7%. (0757) [0438] MS (ESI) m/e |M+H|+/ Rt/%: 354.20/1.42/98.2%. (0758) [0439] 1H NMR (400 MHz, DMSO-c delta 1.69-1.72 (m, 2 H) 1.98 – 2.07 (m, 2 H) 2.11 – 2.17 (m, 2H) 2.20 (s, 3 H) 2.27 (s, 3H) 2.38 (s, 3 H) 2.88 (d, J=11.25 Hz, 2 H) 3.92-3.98 (m, 1 H) 6.26 (s, 1 H) 6.51 (d, J=15.65 Hz, 1 H) 7.11-7.16 (m, 1 H) 7.46 (dd, J=9.05, 2.69 Hz, 1 H) 7.62 – 7.71 (m, 2 H).

With the complex challenges of chemical substances, we look forward to future research findings about 5-Fluoro-2-methylbenzo[d]oxazole

Reference£º
Patent; ALPINE ANDROSCIENCES, INC.; PATIL, Santhosh N.; SARMA, Bugga VNBS; (148 pag.)WO2019/152731; (2019); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Name is 5-Fluoro-2-methylbenzo[d]oxazole, as a common heterocyclic compound, it belongs to benzoxazole compound, and cas is 701-16-6, its synthesis route is as follows.,701-16-6

Reference Example 42-1 (E)-2-(5-fluorobenzo[d]oxazol-2-yl)-N,N-dimethylethen-1-amine 5-Fluoro-2-methylbenzo[d]oxazole (2.00 g, 13 mmol) and N,N-dimethylformamide dimethyl acetal (3.5 mL, 26 mmol) were dissolved in DMF (13 mL), and the solution was stirred for 23 hours at 125C. The reaction liquid was left to cool to room temperature, and the solvent was distilled off under reduced pressure. A residue thus obtained was purified by silica gel column chromatography (hexane:ethyl acetate) (concentration gradient: 28% to 49%), and the title compound (brown crystals, 2.29 g, 84%) was obtained. 1H NMR(CDCl3, 400MHz):delta=2.98(s, 6H),5.03(d, 1H, J=13Hz),6.81(ddd, 1 H, J=3,9,9Hz),7.14(dd, 1H, J=3,9Hz),7.21(dd, 1H, J=4,9Hz),7.56(d , 1H, J=13Hz).

With the complex challenges of chemical substances, we look forward to future research findings about 5-Fluoro-2-methylbenzo[d]oxazole

Reference£º
Patent; Nippon Chemiphar Co., Ltd.; Kinki University; TANAKA Hiroto; OOI Isao; MOGI Yuzo; HIROSE Masaaki; ENDO Tsuyoshi; OGAWA Toru; KAWABATA Atsufumi; (171 pag.)EP3404021; (2018); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

As a common heterocyclic compound, it belong benzoxazole compound,5-Fluoro-2-methylbenzo[d]oxazole,701-16-6,Molecular formula: C8H6FNO,mainly used in chemical industry, its synthesis route is as follows.,701-16-6

General procedure: The SBOs were prepared by the base-catalysed condensation of the appropriate 5-halogeno-2-methylbenzoxazole with the requisite aromatic aldehyde under phase transfer conditions. In a typical experiment, equimolar quantities (5 mmol) of the starting materials were dissolved in dichloromethane (20-50 ml) in the presence of benzyltriethylammonium chloride (3 mmol) and stirred magnetically under a nitrogen atmosphere as an aqueous solution of sodium hydroxide (50%, w/v, 5 ml) was added dropwise over a period of 10 min. After being stirred for 2-36 h until analytical thin layer chromatography indicated that the reaction was complete, the mixture was diluted with water (50 ml) and the SBO was extracted with dichloromethane (3¡Á20 ml), dried (MgSO4), filtered, evaporated under reduced pressure and recrystallized from aqueous methanol or ethanol.

With the synthetic route has been constantly updated, we look forward to future research findings about 5-Fluoro-2-methylbenzo[d]oxazole,belong benzoxazole compound

Reference£º
Article; Ayrton, Stephen T.; Panova, Jekaterina; Michalik, Adam R.; Martin, William H.C.; Gallagher, Richard T.; Bowen, Richard D.; International Journal of Mass Spectrometry; vol. 345-347; (2013); p. 120 – 131;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Name is 5-Fluoro-2-methylbenzo[d]oxazole, as a common heterocyclic compound, it belongs to benzoxazole compound, and cas is 701-16-6, its synthesis route is as follows.,701-16-6

General procedure: The SBOs were prepared by the base-catalysed condensation of the appropriate 5-halogeno-2-methylbenzoxazole with the requisite aromatic aldehyde under phase transfer conditions. In a typical experiment, equimolar quantities (5 mmol) of the starting materials were dissolved in dichloromethane (20-50 ml) in the presence of benzyltriethylammonium chloride (3 mmol) and stirred magnetically under a nitrogen atmosphere as an aqueous solution of sodium hydroxide (50%, w/v, 5 ml) was added dropwise over a period of 10 min. After being stirred for 2-36 h until analytical thin layer chromatography indicated that the reaction was complete, the mixture was diluted with water (50 ml) and the SBO was extracted with dichloromethane (3¡Á20 ml), dried (MgSO4), filtered, evaporated under reduced pressure and recrystallized from aqueous methanol or ethanol.

With the complex challenges of chemical substances, we look forward to future research findings about 5-Fluoro-2-methylbenzo[d]oxazole

Reference£º
Article; Ayrton, Stephen T.; Panova, Jekaterina; Michalik, Adam R.; Martin, William H.C.; Gallagher, Richard T.; Bowen, Richard D.; International Journal of Mass Spectrometry; vol. 345-347; (2013); p. 120 – 131;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Name is 5-Fluoro-2-methylbenzo[d]oxazole, as a common heterocyclic compound, it belongs to benzoxazole compound, and cas is 701-16-6, its synthesis route is as follows.,701-16-6

General procedure: The SBOs were prepared by the base-catalysed condensation of the appropriate 5-halogeno-2-methylbenzoxazole with the requisite aromatic aldehyde under phase transfer conditions. In a typical experiment, equimolar quantities (5 mmol) of the starting materials were dissolved in dichloromethane (20-50 ml) in the presence of benzyltriethylammonium chloride (3 mmol) and stirred magnetically under a nitrogen atmosphere as an aqueous solution of sodium hydroxide (50%, w/v, 5 ml) was added dropwise over a period of 10 min. After being stirred for 2-36 h until analytical thin layer chromatography indicated that the reaction was complete, the mixture was diluted with water (50 ml) and the SBO was extracted with dichloromethane (3¡Á20 ml), dried (MgSO4), filtered, evaporated under reduced pressure and recrystallized from aqueous methanol or ethanol.

With the complex challenges of chemical substances, we look forward to future research findings about 5-Fluoro-2-methylbenzo[d]oxazole

Reference£º
Article; Ayrton, Stephen T.; Panova, Jekaterina; Michalik, Adam R.; Martin, William H.C.; Gallagher, Richard T.; Bowen, Richard D.; International Journal of Mass Spectrometry; vol. 345-347; (2013); p. 120 – 131;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

As a common heterocyclic compound, it belongs to quinuclidine compound,Quinuclidine-4-carboxylic acid hydrochloride,40117-63-3,Molecular formula: C8H14ClNO199,mainly used in chemical industry, its synthesis route is as follows.,701-16-6

[0589] Compound 82: To a stirred solution of Comp-82b (0.1 g, 0.66 mmol) in mixture of THF (5 mL) and ffiuOH (1 mL) was added r-BuOK (0.2 g, 1.98 mmol) and the reaction mixture was stirred for 10 min. Comp-50c(0.1 g, 0.66 mmol) was added portion wise and the reaction mixture was stirred at room temperature for 16 h. Progress of the reaction was monitored by TLC and LCMS. After completion, the reaction mixture was quenched with H20 (5 mL) and extracted with EtOAc (10 mL X 2). The organic layer was washed with brine, dried over anhydrous Na2SO4 and concentrated under reduced pressure to get crude. The crude obtained was purified by prep HPLC to afford (E)-2-(2-(l-cyclopentyl-2,5- dimethyl-lH-pyrrol-3-yl)vinyl)-5-fluorobenzo[d]oxazole (82; 0.08 g, 40%) as white solid. (1026) [0590] HPLC Purity: 99.8% (1027) [0591] MS (ESI) m/e [M+H]+ Rt %: 325.2/2.47/99.4% (1028) [0592] 1H NMR (400 MHz, DMSO- d6) delta 1.62- 1.64 (m, 2 H), 1.82- 1.84 (m, 4 H), 1.98 – 2.08 (m, 2 H), 2.24 (s, 3 H), 2.36 (s, 3 H), 4.54 – 4.67 (m, 1 H), 6.26 (s, 1 H), 6.50 (d, J=15.65 Hz, 1 H), 7.10 – 7.19 (m, 1 H), 7.46 (dd, J=8.80, 2.45 Hz, 1 H), 7.62 – 7.64 (m, 1 H), 7.67 (d, J=15.65 Hz, 1 H).

With the complex challenges of chemical substances, we look forward to future research findings about 5-Fluoro-2-methylbenzo[d]oxazole,belong benzoxazole compound

Reference£º
Patent; ALPINE ANDROSCIENCES, INC.; PATIL, Santhosh N.; SARMA, Bugga VNBS; (148 pag.)WO2019/152731; (2019); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem