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Possible role of plant phenolics in the production of trichothecenes by Fusarium graminearum strains on different fractions of maize kernels

Four trichothecene-producing strains of Fusarium graminearum were grown on three maize grain fractions, whole grain, degermed grain, and the germ, to determine the effect of natural substrates on mycotoxin production. Monitoring the ergosterol content after 25 days of incubation indicated that fungal growth on all grain fractions was comparable. Trichothecene (TCT) production was highest on degermed grain, less on whole grain, and very low or nondetectable on the germ; similar results were found with four different strains. It was concluded that inhibitor(s) of TCT biosynthesis were present in maize germ. The presence of phenolic compounds was investigated in the different fractions. The hydroxamate 4-acetylbenzoxazolin-2-one (4-ABOA), a known inhibitor of mycotoxin production, was found in the degermed and whole grain fractions but not in the germ. Therefore, the TCT inhibition observed on the maize germ fraction used in our study is clearly not linked to 4-ABOA. Other soluble phenolic compounds were found at a much higher concentration in the germ than in the two other fractions. The inhibition property of the soluble ester-bound extracts was tested in liquid culture. A possible role for these compounds is discussed.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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Isolation and characterization of 4-acetyl-benzoxazolin-2-one (4-ABOA), a new benzoxazolinone from Zea mays

The previously unreported 4-acetyl-benzoxazolin-2-one (4-ABOA, 1) was isolated from corn kernels. Its structure was determined by MS, NMR and X-Ray crystallography.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Archives for Chemistry Experiments of 4-Acetylbenzo[d]oxazol-2(3H)-one

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Antineoplastic agents. 556. Isolation and structure of coprinastatin 1 from coprinus cinereus

Cancer cell line bioassay-guided separation of an ethyl acetate extract prepared from a plant-associated fungus, Coprinus cinereus, led to the isolation of three new sesquiterpenes, coprinastatin 1 (1), coprinol (2), and the epimer (4a), of the known sesquiterpene triol 4b. The previously described sesquiterpene 3 and oxazolinone 5 were also isolated. The structure and relative configuration of coprinastatin 1 (1) were determined by HRMS and by ID- and 2D-NMR spectroscopic analyses. The structure of terpene 2 was elucidated by single-crystal X-ray diffraction experiments. The remaining structures were similarly determined, structure 3 by spectroscopic analyses and both 4a and 5 by X-ray crystal structure determination. Coprinastatin 1 (1.) was found to inhibit growth of the murine P388 lymphocytic leukemia cell line and the pathogenic bacterium Neisseria gonorrhoeae.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Brief introduction of 4-Acetylbenzo[d]oxazol-2(3H)-one

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Synthesis of 4-acetylbenzoxazolin-2(3H)-one reported from Zea mays

A three-step alternative synthesis of 4-acetylbenzoxazolin-2(3H)-one (4) is reported. Starting from inexpensive 3-hydroxyacetophenone (1) 3-hydroxy- 2-nitroacetophenone (2) is prepared by nitration followed by catalytic hydrogenation to yield 2-amino-3-hydroxyacetophenone (3) in which a C=O unit is inserted by means of bis(trichloromethyl)carbonate (triphosgene) in the presence of triethylamine to afford 4 in 35% overall yield.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Top Picks: new discover of 4-Acetylbenzo[d]oxazol-2(3H)-one

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A catalyst don’t appear in the overall stoichiometry of the reaction it catalyzes, 70735-79-4, but it must appear in at least one of the elementary reactions in the mechanism for the catalyzed reaction. 70735-79-4, Name is 4-Acetylbenzo[d]oxazol-2(3H)-one, molecular formula is C9H7NO3. In a Article, authors is Qi, Ping£¬once mentioned of 70735-79-4

Synthesis of some new 2(3H)-benzoxazolone and their antihepatodamage activity

The synthesis, characterization and pharmacological activities of a new series of 4-Hydroxy-2(3H)-benzoxazolone are described.CCl4-induced acute liver injury model in mice was determined by serum alanine aminot ransferase(ALT). Among the synthesized compounds, compound 4-hydroxy-2(3H)-benzoxazolone, 4-Acetyl-2(3H)-benzoxazolone, 3-4-Acetoxy-2(3H)-benzoxazolone was found to be the most promising compound for antihepatis.

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Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem