81900-93-8 | Page 3 of 6 | Heterocyclic Building Blocks-Benzoxazole

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Chemical properties determine the actual use. Each compound has specific chemical properties and uses. We look forward to more synthetic routes in the future to expand reaction routes of 81900-93-8, 4-Aminobenzo[d]oxazol-2(3H)-one

81900-93-8, In the next few decades, the world population will flourish. As the population grows rapidly and people all over the world use more and more resources, all industries must consider their environmental impact. 4-Aminobenzo[d]oxazol-2(3H)-one, cas is 81900-93-8,the benzoxazole compound, it is a common compound, a new synthetic route is introduced below.

Commercially available 4-chloro-2-trifluoromethylbenzylamine (1 g, 4.77 mmol) was dissolved in 20ml of AcOEt and at 0C triphosgene (1.41 g, 4.77 mmol) was added to the solution. The mixture was warmed at 80C for 4 hours then evaporated and the residue was dissolved in 5 ml of DMF. The solution of the isocyanate was added dropwise to a solution in DMF (5 ml) of compound lb (475 mg, 3.2 mmol) and the mixture was warmed at 80C for 8 hours. (TLC AcOEt 4 / petroleum ether 6). The solvent was evaporated and the crude was dissolved in AcOEt (30 ml) and washed with water (1 X 20 ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column gave 120 mg of a white solid. Yield = 9.7% rHNM (DMSO,200 MHz) delta 4.45 (2H, d, J = 5.6 Hz), 6.99 (4H, m), 7.65 (1H, d), 7.73 (1H, d), 7.85 (1H, bs), 8.62 (1H, bs), 1 1.04 (1H, bs); [M+1] 386.6 (C16HnClF3N3O3 requires 385.73).

Reference£º
Patent; PHARMESTE S.R.L.; NAPOLETANO, Mauro; TREVISANI, Marcello; PAVANI, Maria Giovanna; FRUTTAROLO, Francesca; WO2011/120604; (2011); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

Introduction of a new synthetic route about 81900-93-8

81900-93-8, In the field of chemistry, the synthetic routes of compounds are constantly being developed and updated. I will also mention this compound in other articles.,81900-93-8 ,4-Aminobenzo[d]oxazol-2(3H)-one, other downstream synthetic routes, hurry up and to see

As a common heterocyclic compound, it belongs to benzoxazole compound, name is 4-Aminobenzo[d]oxazol-2(3H)-one, and cas is 81900-93-8, its synthesis route is as follows.

Commercially available 4-fluoro-2-trifluoromethylbenzylamine (0.5 ml, 3.7 mmol) was dissolved in 20 ml of AcOEt and at 0C triphosgene (1.12 g, 3.7 mmol) was added to the solution. The mixture was warmed at 80C for 4 hours then evaporated and the residue was dissolved in 5ml of DMF. The solution of the isocyanate was added dropwise to a solution in DMF (5ml) of compound lb (360 mg, 2.4 mmol) and the mixture was warmed at 80C for 8 hours. (TLC AcOEt 4 / petroleum ether 6). The solvent was evaporated and the crude was dissolved in AcOEt (30ml) and washed with water (1 X 20 ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column gave 90 mg of a white solid. Yield = 10% ‘HNMR (DMSO, 200 MHz) delta 4.36 (2H, d, J = 5.6 Hz), 6.71 (1H, t, J = 6 Hz), 6.98 (2H, m), 7.56 (4H, m), 8.55 (1H, bs), 1 1.09 (1H, bs); [M+1] 370.2 (C16HnF4N3O3 requires 369.27).

Downstream synthetic route of 4-Aminobenzo[d]oxazol-2(3H)-one

As a common heterocyclic compound, it belongs to benzoxazole compound, name is 4-Aminobenzo[d]oxazol-2(3H)-one, and cas is 81900-93-8, its synthesis route is as follows.

Example 29: 1-(2-(dimethylamino)-4-(trifluoromethyl)benzyl)-3-(2,3-dihydro-2-oxobenzo[d]oxazol-4-yl)urea scheme 1) Preparation of 1-(2-(dimethylamino)-4-(trifluoromethyl)benzyl)-3-(2,3-dihydro-2-oxobenzo[d]oxazol-4-yl)urea Amine 2a (1.2 g, 5.5 mmol) was dissolved in 40ml of AcOEt and at 0C triphosgene (1.63 g, 5.5 mmol) was added to the solution. The mixture was warmed at 80C for 4 hours then evaporated and the residue was dissolved in 5 ml of DMF. The solution of the isocyanate was added dropwise to a solution in DMF (10 ml) of compound 1b (820 mg, 5.5 mmol) and the mixture was warmed at 80C for 8 hours. (TLC AcOEt 7 / petroleum ether 3). The solvent was evaporated and the crude was dissolved in AcOEt (50 ml) and washed with water (1 X 3 0ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column gave 300 mg of a white solid. Yield = 14% 1HNMR (DMSO, 200 MHz) delta 2.51 (6H, s), 4.71 (2H, d, J = 5.6 Hz), 6.55 (2H, d, J = 8.2 Hz), 7.05 (1H, t, J = 7.6 Hz), 7.40 (1H, m), 7.51 (1H, d), 10.06 (1H, bt), 11.53 (1H, bs), 11.80 (1H, bs); [M+1] 395.1 (C18H17F3N4O3 requires 394.35).

Reference£º
Patent; Pharmeste S.r.l.; EP2377850; (2011); A1;,
Benzoxazole – Wikipedia
Benzoxazole | C7H5NO – PubChem

A new application about 81900-93-8

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Reference of 81900-93-8. In my other articles, you can also check out more blogs about 81900-93-8

Reference of 81900-93-8, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 81900-93-8, 4-Aminobenzo[d]oxazol-2(3H)-one, introducing its new discovery.

TRPV1 VANILLOID RECEPTOR ANTAGONISTS WITH A BICYCLIC PORTION

The invention discloses compounds of formula I wherein Y is a group of formula A, B, C, D, or E: and W, Q, n, R1, R2, R3, U1-U5, J and K have the meanings given in the description. The compounds of formula I are TRPV1 antagonists and are useful as active ingredients of pharmaceutical compositions for the treatment of pain and other conditions ameliorated by the inhibition of the vanilloid receptor TRPV 1.

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Awesome and Easy Science Experiments about 81900-93-8

The proportionality constant is the rate constant for the particular unimolecular reaction. the reaction rate is directly proportional to the concentration of the reactant. I hope my blog about 81900-93-8 is helpful to your research. Synthetic Route of 81900-93-8

Synthetic Route of 81900-93-8, Catalysts function by providing an alternate reaction mechanism that has a lower activation energy than would be found in the absence of the catalyst. In some cases, the catalyzed mechanism may include additional steps.In a article, 81900-93-8, molcular formula is C7H6N2O2, introducing its new discovery.

Benzoxazole compound synthesized by nitration by-products of aromatic hydrocarbons and application thereof (by machine translation)

The invention discloses a method for synthesizing a benzoxazole compound by using aromatic nitration by-products and an application. The main process can be expressed as: converting 2, 4 -dinitrochlorobenzene production enterprises nitration by-products, and obtaining 2, 4 -dinitrochlorobenzene, 2, 6 -dinitrochlorobenzene (I) and a small amount of residues through fractional crystallization. Th 2, 6 -dinitrochlorobenzene (I) is a main starting material, is subjected to hydrolysis, selective catalytic hydrogenation reduction, cyclization, halogenation, carbon carbon coupling and other processes to synthesize a benzoxazole compound; and the like. The chemical intermediate, such as o-aminophenol, 2 – amino -4 – nitrophenol, 2 – amino -5 – nitrophenol, hydrochloride and the like, is synthesized by taking the compound obtained in the above process as a main raw material to synthesize a series of chemical intermediates with important application. To the method, industrial by-products are converted into aromatic aminophenolic products with high added value, 2, 4 -dinitrochlorobenzene production enterprises are reduced in industrial danger, the enterprise exhibition range, and enterprise economic benefits are improved. (by machine translation)

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

Discovery of 81900-93-8

Balanced chemical reaction does not necessarily reveal either the individual elementary reactions by which a reaction occurs or its rate law.Synthetic Route of 81900-93-8. In my other articles, you can also check out more blogs about 81900-93-8

Synthetic Route of 81900-93-8, Chemistry is the science of change. But why do chemical reactions take place? Why do chemicals react with each other? The answer is in thermodynamics and kinetics.In a document type is Patent, and a compound is mentioned, 81900-93-8, 4-Aminobenzo[d]oxazol-2(3H)-one, introducing its new discovery.

TRPV1 vanilloid receptor antagonists with a bicyclic portion

The invention discloses compounds of formula I wherein Y s selected from a group of formula and W, Q, n, R1, R2, R3, U1-U5 have the meanings given in the description. The compounds of formula I are TRPV1 antagonists and are useful as active ingredients of pharmaceutical compositions for the treatment of pain and other conditions ameliorated by the inhibition of the vanilloid receptor TRPV1. 1.

Reference£º
Benzoxazole – Wikipedia,
Benzoxazole | C7H5NO – PubChem

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With the complex challenges of chemical substances, we look forward to future research findings about 4-Aminobenzo[d]oxazol-2(3H)-one

It is a common heterocyclic compound, the benzoxazole compound, 4-Aminobenzo[d]oxazol-2(3H)-one, cas is 81900-93-8 its synthesis route is as follows.,81900-93-8

Amine 2a (1.2 g, 5.5 mmol) (Scheme 7) was dissolved in 40ml of AcOEt and at 0C triphosgene (1.63 g, 5.5 mmol) was added to the solution. The mixture was warmed at 80C for 4 hours then evaporated and the residue was dissolved in 5 ml of DMF. The solution of the isocyanate was added dropwise to a solution in DMF (10 ml) of compound lb (820 mg, 5.5 mmol) and the mixture was warmed at 80C for 8 hours. (TLC AcOEt 7 / petroleum ether 3). The solvent was evaporated and the crude was dissolved in AcOEt (50 ml) and washed with water (1 X 3 0ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column gave 300 mg of a white solid. Yield = 14% ‘HNMR (DMSO, 200 MHz) delta 2.51 (6H, s), 4.71 (2H, d, J = 5.6 Hz), 6.55 (2H, d, J = 8.2 Hz), 7.05 (IH, t, J = 7.6 Hz), 7.40 (IH, m), 7.51 (IH, d), 10.06 (IH, bt), 1 1.53 (IH, bs), 1 1.80 (IH, bs); [M+1] 395.1 (C18H17F3N4O3 requires 394.35).

With the complex challenges of chemical substances, we look forward to future research findings about 4-Aminobenzo[d]oxazol-2(3H)-one

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With the complex challenges of chemical substances, we look forward to future research findings about 4-Aminobenzo[d]oxazol-2(3H)-one

Name is 4-Aminobenzo[d]oxazol-2(3H)-one, as a common heterocyclic compound, it belongs to benzoxazole compound, and cas is 81900-93-8, its synthesis route is as follows.,81900-93-8

Commercially available p-chlorobenzylamine (1.6 g, 1 1.4 mmol) was dissolved in 60ml of AcOEt and at 0C triphosgene (3.38 g, lequiv.) was added to the solution. The mixture was warmed at 80C for 4 hours then evaporated and the residue was dissolved in 30 ml of DMF. The solution of the isocyanate was added dropwise to a solution in DMF (10 ml) of compound lb (1.7 g, 1 1.4 mmol) and the mixture was warmed at 80C for 8 hours. (TLC AcOEt 7 / petroleum ether 3). The solvent was evaporated and the crude was dissolved in AcOEt (80 ml) and washed with water (1 X 50 ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column gave 500mg of a white solid. Yield = 14% ‘HNMR (DMSO, 200 MHz) delta 4.57 (2H, d, J = 5.8 Hz), 6.53 (2H, m), 7.04 (1H, m), 7.41 (4H, s), 9.88 (1H, t), 1 1.53 (1H, s), 1 1.80 (1H, bs); [M+1] 318.5 (C15H12ClN3O3 requires 317.73).

With the complex challenges of chemical substances, we look forward to future research findings about 4-Aminobenzo[d]oxazol-2(3H)-one

New learning discoveries about 81900-93-8

With the rapid development of chemical substances, we look forward to future research findings about 4-Aminobenzo[d]oxazol-2(3H)-one

4-Aminobenzo[d]oxazol-2(3H)-one, cas is 81900-93-8, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,81900-93-8

With the rapid development of chemical substances, we look forward to future research findings about 4-Aminobenzo[d]oxazol-2(3H)-one

Extracurricular laboratory: Synthetic route of 81900-93-8

As the rapid development of chemical substances, we look forward to future research findings about 81900-93-8

4-Aminobenzo[d]oxazol-2(3H)-one, cas is 81900-93-8, it is a common heterocyclic compound, the benzoxazole compound, its synthesis route is as follows.,81900-93-8

Amine 2b (289 mg, 1.2 mmol) (Scheme 7) was dissolved in 20ml of AcOEt and at 0C triphosgene (356 mg, 1.2 mmol) was added to the solution. The mixture was warmed at 80C for 4 hours then evaporated and the residue was dissolved in 5ml of DMF. The solution of the isocyanate was added dropwise to a solution in DMF (10 ml) of compound lb (180 mg, 1.2 mmol) and the mixture was warmed at 80C for 8 hours. (TLC AcOEt). The solvent was evaporated and the crude was dissolved in AcOEt (30 ml) and washed with water (1 X 20 ml) and brine. The organic phase was dried over sodium sulfate and concentrated under vacuum. The purification of the crude residue by chromatographic column gave lOOmg of a white solid. Yield = 20% ‘HNMR (DMSO, 200 MHz) delta 1.94 (4H, m), 3.23 (4H, m), 4.67 (2H, d, J = 5.6 Hz), 6.55 (2H, dd, J = 8.8 Hz, J’ = 1.2 Hz), 7.05 (1H, t, J = 8.2 Hz), 7.17 (2H, d, J = 7.2 Hz), 7.46 (1H, d), 9.98 (1H, t), 1 1.53 (1H, bs), 1 1.80 (1H, bs); [M+1] 421.2 (C2oH19F3N4O3 requires 420.39).

As the rapid development of chemical substances, we look forward to future research findings about 81900-93-8